Detailed information for compound 723054

Basic information

Technical information
  • TDR Targets ID: 723054
  • Name: N-[(4-ethoxyphenyl)methyl]-2H-tetrazol-5-amin e
  • MW: 219.243 | Formula: C10H13N5O
  • H donors: 2 H acceptors: 3 LogP: 1.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)CNc1n[nH]nn1
  • InChi: 1S/C10H13N5O/c1-2-16-9-5-3-8(4-6-9)7-11-10-12-14-15-13-10/h3-6H,2,7H2,1H3,(H2,11,12,13,14,15)
  • InChiKey: PTJXEYCDAVRUAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-ethoxybenzyl)-(2H-tetrazol-5-yl)amine
  • N-[(4-ethoxyphenyl)methyl]-2H-1,2,3,4-tetrazol-5-amine
  • STK285344
  • (4-Ethoxy-benzyl)-(2H-tetrazol-5-yl)-amine
  • AN-465/41587318
  • N-(4-ethoxybenzyl)-N-(2H-tetraazol-5-yl)amine
  • BAS 07019894
  • STOCK6S-10415

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable reductase 0.0104 0.1772 0.8342
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0059 0.0418 0.2819
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1384 0.9582
Trypanosoma brucei polo-like protein kinase 0.0091 0.1384 0.9582
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2121 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0379 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.1384 0.3862
Schistosoma mansoni hypothetical protein 0.0164 0.3559 0.3535
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1384 0.9582
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1772 0.7951
Onchocerca volvulus 0.0379 1 1
Echinococcus granulosus geminin 0.0164 0.3559 1
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0093 0.1443 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0059 0.0418 0.1136
Schistosoma mansoni hypothetical protein 0.0164 0.3559 0.3535
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.1384 0.137
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0059 0.0418 0.0383
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1772 0.8342
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0059 0.0418 0.2819
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1384 1
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0093 0.1443 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0059 0.0418 0.5
Loa Loa (eye worm) hypothetical protein 0.0379 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2121 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0093 0.1443 0.403
Loa Loa (eye worm) methionine aminopeptidase type I 0.0093 0.1443 0.143
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0379 1 1
Toxoplasma gondii methionine aminopeptidase 0.0093 0.1443 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0093 0.1443 0.403
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1384 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.1384 0.137
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0379 1 1
Schistosoma mansoni tyrosinase precursor 0.0379 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1772 0.8342
Schistosoma mansoni tyrosinase precursor 0.0379 1 1
Brugia malayi Common central domain of tyrosinase family protein 0.0379 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1384 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.1384 0.9582
Loa Loa (eye worm) tyrosinase 1 0.0379 1 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0379 1 1
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0059 0.0418 0.2819
Onchocerca volvulus 0.0379 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.1384 0.1352
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1772 0.8342
Toxoplasma gondii methionine aminopeptidase 0.0059 0.0418 0.2819
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1772 0.8342
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0059 0.0418 0.1912
Onchocerca volvulus 0.0379 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2121 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0059 0.0418 0.5
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0093 0.1443 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.1384 0.5
Mycobacterium ulcerans methionine aminopeptidase 0.0059 0.0418 0.5
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1772 0.8342
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0093 0.1443 1
Loa Loa (eye worm) hypothetical protein 0.0379 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1384 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2121 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0093 0.1443 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.3027 0.3016
Brugia malayi hypothetical protein 0.0146 0.3027 0.3016
Chlamydia trachomatis methionine aminopeptidase 0.0059 0.0418 0.5
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0093 0.1443 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0059 0.0418 0.1912
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1384 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1384 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0093 0.1443 1
Echinococcus multilocularis geminin 0.0164 0.3559 1
Treponema pallidum methionine aminopeptidase (map) 0.0059 0.0418 0.5
Onchocerca volvulus 0.0146 0.3027 0.1907
Trypanosoma brucei methionine aminopeptidase, putative 0.0093 0.1443 1
Onchocerca volvulus 0.0379 1 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0059 0.0418 0.0383
Loa Loa (eye worm) ShTK domain-containing protein 0.0379 1 1
Giardia lamblia Kinase, PLK 0.0091 0.1384 0.5
Brugia malayi Methionine aminopeptidase protein type I 0.0093 0.1443 0.143
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1384 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.1384 0.3862
Loa Loa (eye worm) ShTK domain-containing protein 0.0379 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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