Detailed information for compound 723508

Basic information

Technical information
  • TDR Targets ID: 723508
  • Name: 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]s ulfanyl]-N-cyclohexylacetamide
  • MW: 351.851 | Formula: C16H18ClN3O2S
  • H donors: 1 H acceptors: 3 LogP: 4.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCCC1)CSc1nnc(o1)c1cccc(c1)Cl
  • InChi: 1S/C16H18ClN3O2S/c17-12-6-4-5-11(9-12)15-19-20-16(22-15)23-10-14(21)18-13-7-2-1-3-8-13/h4-6,9,13H,1-3,7-8,10H2,(H,18,21)
  • InChiKey: BNTXLBQRFZGYQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclohexyl-acetamide
  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-cyclohexylacetamide
  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-cyclohexyl-acetamide
  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclohexyl-ethanamide
  • IFLab1_002707
  • STK226292
  • ZINC00917095
  • 2-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-N-cyclohexyl-acetamide
  • BAS 03574821

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0115
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0026 0.0424 0.0424
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0017 0.0109 0.8884
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0122 0.0252
Schistosoma mansoni lamin 0.0026 0.0442 0.0949
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0082 0.249 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0093 0.2881 0.6271
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0007 0.0007
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0093 0.2881 0.6271
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0122 0.0461
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0115
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0122 0.0252
Leishmania major DNA polymerase eta, putative 0.0017 0.0122 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.1122 0.1122
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0122 1
Echinococcus granulosus CAAX prenyl protease 2 0.0082 0.249 0.5418
Treponema pallidum hypothetical protein 0.0017 0.0109 0.5
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0007 0.0007
Echinococcus granulosus intermediate filament protein 0.0026 0.0442 0.0949
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0122 0.0252
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0442 0.0442
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0007 0.0002
Echinococcus multilocularis lamin dm0 0.0026 0.0442 0.0949
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0122 0.0122
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0082 0.249 1
Schistosoma mansoni hypothetical protein 0.005 0.1315 0.2855
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.02 0.02
Brugia malayi CAAX amino terminal protease family protein 0.0082 0.249 0.249
Echinococcus granulosus high voltage activated calcium channel beta 0.014 0.459 1
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0017 0.0109 0.8884
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0122 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.2881 0.6271
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0082 0.249 1
Echinococcus multilocularis sodium channel protein 0.0039 0.0928 0.2011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Loa Loa (eye worm) hypothetical protein 0.0093 0.2881 0.2881
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0031 0.0606 0.0606
Toxoplasma gondii transporter, cation channel family protein 0.0019 0.02 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0122 0.0122
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0082 0.249 0.5418
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Echinococcus multilocularis musashi 0.0026 0.0442 0.0949
Mycobacterium tuberculosis Probable integral membrane protein 0.0017 0.0109 0.8884
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0082 0.249 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0122
Trypanosoma brucei CAAX amino terminal protease, putative 0.0082 0.249 1
Onchocerca volvulus 0.0026 0.0442 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0122 0.0461
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0007 0.0002
Toxoplasma gondii hypothetical protein 0.0017 0.0109 0.528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Schistosoma mansoni DNA polymerase eta 0.0017 0.0122 0.0252
Loa Loa (eye worm) hypothetical protein 0.0045 0.1122 0.1122
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0007 0.0007
Giardia lamblia Hypothetical protein 0.0082 0.249 1
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.014 0.459 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.1122 0.1122
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0606 0.0606
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0122 0.0461
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Loa Loa (eye worm) voltage-dependent calcium channel 0.0019 0.02 0.02
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0122 0.0461
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0122 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.0928 0.2011
Loa Loa (eye worm) hypothetical protein 0.0082 0.249 0.249
Toxoplasma gondii hypothetical protein 0.0017 0.0109 0.528
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.2881 0.6271
Schistosoma mansoni lamin 0.0026 0.0442 0.0949
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0007 0.0007
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.2881 0.6271
Echinococcus granulosus dna polymerase kappa 0.0017 0.0122 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Leishmania major DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Toxoplasma gondii CAAX amino terminal protease family protein 0.0017 0.0109 0.528
Chlamydia trachomatis hypothetical protein 0.0017 0.0109 0.5
Trypanosoma brucei unspecified product 0.0017 0.0122 0.0461
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0007 0.0002
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0056 0.1553 0.6225
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0109 0.8884
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0093 0.2881 0.2881
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0442 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0007 0.0002
Brugia malayi isocitrate dehydrogenase 0.0014 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.0017 0.0115 0.5557
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0093 0.2881 0.6271
Onchocerca volvulus 0.0026 0.0442 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.2881 0.6271
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0288 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0122 0.0461
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0122 0.0461
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0093 0.2881 0.6271
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0056 0.1553 0.6225
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0007 0.0002
Plasmodium falciparum protease, putative 0.0017 0.0109 1
Echinococcus granulosus dna polymerase eta 0.0017 0.0122 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0007 0.0002
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0082 0.249 0.5418
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0122 0.0252
Echinococcus granulosus lamin dm0 0.0026 0.0442 0.0949
Echinococcus granulosus lamin 0.0026 0.0442 0.0949
Plasmodium vivax protease, putative 0.0017 0.0109 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0093 0.2881 0.6271
Loa Loa (eye worm) calcium channel 0.0093 0.2881 0.2881
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.1122 0.1122
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.2881 0.6271
Schistosoma mansoni voltage-gated cation channel 0.0093 0.2881 0.6271
Echinococcus granulosus voltage dependent calcium channel 0.0019 0.02 0.0422
Entamoeba histolytica CAAX prenyl protease family 0.0082 0.249 1
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0122 1
Echinococcus multilocularis dna polymerase eta 0.0017 0.0122 0.0252
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0007 0.0007
Brugia malayi intermediate filament protein 0.0026 0.0442 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Schistosoma mansoni hypothetical protein 0.0031 0.0606 0.1307
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0122 0.0461
Schistosoma mansoni intermediate filament proteins 0.0026 0.0442 0.0949
Echinococcus multilocularis lamin 0.0026 0.0442 0.0949
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0122 1
Echinococcus multilocularis CAAX prenyl protease 2 0.0082 0.249 0.5418
Echinococcus granulosus voltage dependent calcium channel 0.0093 0.2881 0.6271
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0122 0.0252
Echinococcus multilocularis high voltage activated calcium channel beta 0.014 0.459 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.2881 0.6271

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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