Detailed information for compound 723811

Basic information

Technical information
  • TDR Targets ID: 723811
  • Name: 4-(5-chloro-2-methoxy-4-methylphenyl)sulfonyl -2,6-dimethylmorpholine
  • MW: 333.831 | Formula: C14H20ClNO4S
  • H donors: 0 H acceptors: 2 LogP: 2.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C)c(cc1S(=O)(=O)N1CC(C)OC(C1)C)Cl
  • InChi: 1S/C14H20ClNO4S/c1-9-5-13(19-4)14(6-12(9)15)21(17,18)16-7-10(2)20-11(3)8-16/h5-6,10-11H,7-8H2,1-4H3
  • InChiKey: MOFCHEKCLKQQRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(5-chloro-2-methoxy-4-methyl-phenyl)sulfonyl-2,6-dimethyl-morpholine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0222 0.0078
Brugia malayi MAP kinase sur-1 0.0052 0.0659 0.1845
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0659 0.816
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0253 0.0716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1218 0.1089
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0332 0.019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0253 0.008
Entamoeba histolytica hypothetical protein 0.0024 0.0256 0.0087
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1984 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0659 0.0522
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0256 0.0636
Brugia malayi Pre-SET motif family protein 0.003 0.0347 0.0726
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0659 0.0522
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.1129 0.0999
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0659 0.816
Trichomonas vaginalis set domain proteins, putative 0.024 0.3348 0.7956
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.1129 0.3533
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.1129 0.0999
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0661 0.1219
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1218 0.1089
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0659 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1129 0.2326
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0757 0.0622
Echinococcus multilocularis microtubule associated protein 2 0.0706 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0222 0.0277
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0256 0.5
Echinococcus granulosus neuropeptide s receptor 0.0473 0.6673 0.6624
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0659 0.1112
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0659 0.1112
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0757 0.0622
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0256 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0661 0.1219
Loa Loa (eye worm) hypothetical protein 0.003 0.0347 0.0478
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0757 1
Brugia malayi Pre-SET motif family protein 0.0211 0.2932 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0256 0.3089
Leishmania major importin beta-1 subunit, putative 0.0024 0.0253 0.0585
Trypanosoma brucei protein kinase, putative 0.0052 0.0659 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0757 0.2902
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0222 0.3367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0412 0.0632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.4152 1
Schistosoma mansoni hypothetical protein 0.0313 0.4377 0.4294
Echinococcus multilocularis hedgehog 0.0192 0.2662 0.2555
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0347 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0659 0.1112
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.1129 0.0999
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.6673 0.6624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1218 0.1089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0643 0.1787
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.6673 0.6624
Onchocerca volvulus 0.024 0.3348 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1218 0.1089
Schistosoma mansoni hypothetical protein 0.0035 0.0412 0.0271
Onchocerca volvulus 0.0085 0.1129 0.2607
Brugia malayi Hint module family protein 0.0052 0.0661 0.1851
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1984 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0643 0.1787
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0256 0.0636
Echinococcus multilocularis snurportin 1 0.0313 0.4377 0.4294
Schistosoma mansoni microtubule-associated protein tau 0.0706 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0659 0.1112
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.6673 0.6624
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.4152 1
Schistosoma mansoni ran 0.0022 0.0222 0.0078
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0256 0.2725
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0332 0.5042
Echinococcus granulosus snurportin 1 0.0313 0.4377 0.4294
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0347 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2932 0.6585
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0347 0.2336
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0253 0.008
Schistosoma mansoni hypothetical protein 0.014 0.1916 0.1797
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0332 0.5042
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0659 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0659 0.0522
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0412 0.096
Plasmodium vivax SET domain protein, putative 0.003 0.0347 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0332 0.8822
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0757 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0659 0.0522
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0222 0.0078
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0332 0.2061
Entamoeba histolytica hypothetical protein 0.0024 0.0253 0.008
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0256 0.0636
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0757 0.0622
Loa Loa (eye worm) hypothetical protein 0.0051 0.0643 0.1177
Echinococcus granulosus Desert hedgehog protein 0.0192 0.2662 0.2555
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0659 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0253 0.008
Schistosoma mansoni importin beta-1 0.0029 0.0332 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1218 0.1089
Plasmodium falciparum importin beta, putative 0.0029 0.0332 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0643 0.1177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0347 0.0205
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1218 0.3851
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4152 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0222 0.0182
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0757 0.2902
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.4152 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0347 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0347 0.0205
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.4377 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0659 0.1112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0757 0.2902
Brugia malayi RNA, U transporter 1 0.0083 0.1103 0.3439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1218 0.1089
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0659 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0331 0.0189
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0659 0.1215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1218 0.1089
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0659 0.0522
Loa Loa (eye worm) hypothetical protein 0.0029 0.0332 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0347 0.0205
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1218 0.2536
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0347 0.0205
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0659 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0332 0.019
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0659 0.816
Schistosoma mansoni ran 0.0022 0.0222 0.0078
Brugia malayi Hint module family protein 0.0052 0.0661 0.1851
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0757 0.0622
Brugia malayi Importin beta-1 subunit 0.0029 0.0332 0.0673
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1984 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0256 0.3885
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0757 0.2902
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.4152 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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