TDR Targets

Basic information

Technical information

TDR Targets ID: 725623
Name: 1-(4-ethoxyphenyl)-N-(furan-2-ylmethyl)methan amine
MW: 231.29 | Formula: C14H17NO2
H donors: 1 H acceptors: 0 LogP: 2.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)CNCc1ccco1
InChi: 1S/C14H17NO2/c1-2-16-13-7-5-12(6-8-13)10-15-11-14-4-3-9-17-14/h3-9,15H,2,10-11H2,1H3
InChiKey: FOMMAQICXGVACL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-ethoxyphenyl)-N-(2-furylmethyl)methanamine
(4-ethoxybenzyl)-(2-furylmethyl)amine
SBB007180
Oprea1_345834
(4-Ethoxy-benzyl)-furan-2-ylmethyl-amine
BAS 04881756

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	alpha-glucosidase	0.0159	0.2098	0.3461
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0088	0.092	0.0809
Echinococcus granulosus	lysosomal alpha glucosidase	0.0184	0.2529	0.4215
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0042	0.014	0.0033
Loa Loa (eye worm)	TAR-binding protein	0.0197	0.2741	0.4153
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0184	0.2529	0.4215
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0186	0.2558	0.4267
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.006	0.045	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0381	0.5832	0.9051
Trichomonas vaginalis	glucosylceramidase, putative	0.0292	0.4339	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0202	0.2826	0.6412
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.013	0.0015
Leishmania major	hypothetical protein, conserved	0.0052	0.031	0.0191
Echinococcus granulosus	GPCR family 2	0.0132	0.1648	0.2674
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.006	0.045	0.0333
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0417	0.6431	1
Echinococcus granulosus	tar DNA binding protein	0.0197	0.2741	0.4588
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0155	0.2037	0.3355
Loa Loa (eye worm)	hypothetical protein	0.0285	0.4217	0.6492
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.2558	0.4267
Trichomonas vaginalis	ap endonuclease, putative	0.006	0.045	0.0779
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2653	0.6002
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0298	0.4435	0.4367
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2653	0.6002
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.02	0.0187
Toxoplasma gondii	hypothetical protein	0.0101	0.1139	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.006	0.045	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0417	0.6431	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0186	0.2558	0.4267
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.2741	0.4588
Schistosoma mansoni	hypothetical protein	0.0041	0.013	0.0015
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.013	0.0015
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.2741	0.4588
Loa Loa (eye worm)	hypothetical protein	0.0042	0.014	0.003
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.006	0.045	0.5
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0184	0.2529	0.3932
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0186	0.2558	0.4267
Mycobacterium ulcerans	hypothetical protein	0.0331	0.5	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.006	0.045	1
Schistosoma mansoni	alpha-glucosidase	0.0159	0.2098	0.3461
Echinococcus multilocularis	GPCR, family 2	0.0132	0.1648	0.2674
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0042	0.014	0.0033
Onchocerca volvulus	Glucosylceramidase homolog	0.0192	0.2653	1
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0042	0.014	0.0033
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0041	0.0121	0.0189
Echinococcus multilocularis	tar DNA binding protein	0.0197	0.2741	0.4588
Echinococcus granulosus	sodium:glucose cotransporter	0.0042	0.014	0.0033
Trichomonas vaginalis	glucosylceramidase, putative	0.0292	0.4339	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.031	0.0299
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0042	0.014	0.0188
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0629	1	1
Loa Loa (eye worm)	hypothetical protein	0.0417	0.6431	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0186	0.2558	0.3862
Toxoplasma gondii	exonuclease III APE	0.006	0.045	0.3229
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0298	0.4435	0.4367
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.013	0.0015
Echinococcus granulosus	high affinity choline transporter 1	0.0381	0.5832	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0151	0.1964	0.3227
Brugia malayi	acetyltransferase, GNAT family protein	0.0155	0.2037	0.3168
Trichomonas vaginalis	ap endonuclease, putative	0.006	0.045	0.0779
Schistosoma mansoni	hypothetical protein	0.0132	0.1648	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1648	0.242
Trichomonas vaginalis	glucosylceramidase, putative	0.0292	0.4339	1
Brugia malayi	hypothetical protein	0.0093	0.0993	0.1544
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0136	0.0457
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0042	0.014	0.0033
Trichomonas vaginalis	glucosylceramidase, putative	0.0292	0.4339	1
Schistosoma mansoni	hypothetical protein	0.0132	0.1648	0.2674
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.006	0.045	0.0333
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.006	0.045	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.031	0.5547
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2653	0.6002
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0298	0.4435	0.4367
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2653	0.6002
Loa Loa (eye worm)	RNA binding protein	0.0197	0.2741	0.4153
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0993	0.1382
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2653	0.6002
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.02	0.0774
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0184	0.2529	0.4215
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.031	0.5547
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0629	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0292	0.4339	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0292	0.4339	0.6747
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0292	0.4339	0.6684
Brugia malayi	GH02984p	0.0381	0.5832	0.9069
Toxoplasma gondii	LsmAD domain-containing protein	0.0052	0.031	0.1857
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0417	0.6431	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0993	0.1382
Schistosoma mansoni	hypothetical protein	0.0285	0.4217	0.7172
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0132	0.1648	0.2563
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0132	0.1648	0.2674
Brugia malayi	TAR-binding protein	0.0197	0.2741	0.4263
Schistosoma mansoni	inositol transporter	0.0042	0.014	0.0033
Plasmodium vivax	ataxin-2 like protein, putative	0.0052	0.031	0.441
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0132	0.1648	0.2674
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0042	0.014	0.0033
Entamoeba histolytica	hypothetical protein	0.0041	0.013	0.0268
Schistosoma mansoni	ap endonuclease	0.006	0.045	0.0575
Treponema pallidum	exodeoxyribonuclease (exoA)	0.006	0.045	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2653	0.6002
Trypanosoma brucei	PAB1-binding protein , putative	0.0052	0.031	0.0191
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0088	0.092	0.0809
Schistosoma mansoni	ap endonuclease	0.006	0.045	0.0575
Entamoeba histolytica	hypothetical protein	0.0041	0.013	0.0268
Onchocerca volvulus		0.0107	0.1224	0.4314
Brugia malayi	hypothetical protein	0.0052	0.031	0.0482
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.006	0.045	0.0575
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0042	0.014	0.0033
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.2741	0.4588
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0108	0.1245	0.1138
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.2741	0.4588
Schistosoma mansoni	hypothetical protein	0.0132	0.1648	0.2674
Brugia malayi	latrophilin 2 splice variant baaae	0.0285	0.4217	0.6558
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0629	1	1
Echinococcus multilocularis	high affinity choline transporter 1	0.0381	0.5832	1
Brugia malayi	RNA recognition motif domain containing protein	0.0197	0.2741	0.4263
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.006	0.045	0.0333
Entamoeba histolytica	hypothetical protein	0.0041	0.013	0.0268
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.02	0.0187
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0155	0.2037	0.3355
Schistosoma mansoni	tar DNA-binding protein	0.0197	0.2741	0.4588
Echinococcus multilocularis	solute carrier family 5	0.0042	0.014	0.0033
Trichomonas vaginalis	glucosylceramidase, putative	0.0202	0.2826	0.6412
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0132	0.1648	0.2674
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.006	0.045	0.0575
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.006	0.045	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0186	0.2558	0.4267
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0132	0.1648	0.242
Loa Loa (eye worm)	acetyltransferase	0.0155	0.2037	0.3036
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0331	0.5	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.2558	0.4267
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0088	0.092	0.0809
Brugia malayi	Latrophilin receptor protein 2	0.0132	0.1648	0.2563
Schistosoma mansoni	hypothetical protein	0.0132	0.1648	0.2674
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0184	0.2529	0.3815
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.02	0.0774
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.031	0.0191
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0088	0.092	0.0809
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.031	0.0191
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0186	0.2558	0.3978
Brugia malayi	RNA binding protein	0.0197	0.2741	0.4263
Schistosoma mansoni	eyes absent homolog	0.0093	0.0993	0.1527
Echinococcus granulosus	solute carrier family 5	0.0042	0.014	0.0033
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.006	0.045	0.0333
Trichomonas vaginalis	glucosylceramidase, putative	0.0292	0.4339	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0197	0.2741	0.4153
Schistosoma mansoni	sodium/solute symporter	0.0042	0.014	0.0033
Brugia malayi	exodeoxyribonuclease III family protein	0.006	0.045	0.07
Schistosoma mansoni	inositol transporter	0.0042	0.014	0.0033
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.2558	0.4267
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2653	0.6002
Brugia malayi	hypothetical protein	0.0041	0.013	0.0202
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0132	0.1648	0.2674
Brugia malayi	Sodium:solute symporter family protein	0.0042	0.014	0.0218
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.02	0.0138
Entamoeba histolytica	hypothetical protein	0.0041	0.013	0.0268
Schistosoma mansoni	high-affinity choline transporter	0.0381	0.5832	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 725623