Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.4498 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.4833 | 0.4833 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.1618 | 0.2393 |
Schistosoma mansoni | flap endonuclease-1 | 0.0025 | 0.5947 | 0.5947 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.4498 | 0.4498 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.4498 | 0.6653 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.1491 | 0.2204 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.4498 | 0.6653 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.4498 | 0.6653 |
Entamoeba histolytica | recQ family helicase, putative | 0.001 | 0.1491 | 0.1491 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.4498 | 0.6653 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1618 | 0.2393 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 0.6762 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.1618 | 0.1618 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.4833 | 0.7148 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.4833 | 0.4833 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 0.6762 | 0.6762 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.4833 | 0.7148 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0021 | 0.4833 | 0.7148 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.4498 | 0.4498 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.4498 | 0.6653 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.4498 | 0.6653 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.4498 | 0.4498 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.4833 | 0.7148 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.4833 | 0.4833 |
Entamoeba histolytica | Flap nuclease, putative | 0.0027 | 0.6762 | 0.6762 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.6762 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.1618 | 0.2393 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.4833 | 0.4833 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.4833 | 0.7148 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 0.6762 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.4498 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.4833 | 0.7148 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.6762 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1618 | 0.2393 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 0.6762 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.4833 | 0.7148 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.4833 | 0.7148 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.4498 | 0.6653 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.6762 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 0.6762 | 0.6762 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.4498 | 0.4498 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.1618 | 0.1618 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.4833 | 0.7148 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.4498 | 0.4498 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.4833 | 0.7148 |
Plasmodium vivax | ATP-dependent DNA helicase Q1, putative | 0.001 | 0.1491 | 0.2204 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.4498 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.4833 | 0.4833 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.6762 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.1491 | 0.1491 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 0.6762 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.4833 | 0.7148 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0011 | 0.1618 | 0.2393 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.4833 | 0.4833 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.4498 | 0.6653 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.4498 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.4498 | 0.6653 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.4833 | 0.4833 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.4498 | 0.6653 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.4833 | 0.4833 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0011 | 0.1618 | 0.2393 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.4833 | 0.4833 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.6762 | 0.6762 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.4833 | 0.4833 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.4833 | 0.4833 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.4833 | 0.7148 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.4498 | 0.6653 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.4833 | 0.7148 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.6762 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.4833 | 0.7148 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.4498 | 0.4498 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.4833 | 0.4833 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.