Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.1066 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.0088 | 0.0013 | 1 |
Echinococcus multilocularis | casein kinase I alpha | 0.0088 | 0.0013 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.0088 | 0.0013 | 0.5 |
Echinococcus multilocularis | casein kinase I delta | 0.0088 | 0.0013 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0088 | 0.0013 | 1 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0088 | 0.0013 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0088 | 0.0013 | 1 |
Brugia malayi | casein kinase 1, delta | 0.0088 | 0.0013 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0907 | 1 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0088 | 0.0013 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0088 | 0.0013 | 1 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0088 | 0.0013 | 0.5 |
Entamoeba histolytica | casein kinase 1, putative | 0.0088 | 0.0013 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0088 | 0.0013 | 0.5 |
Giardia lamblia | Kinase, CK1 Casein kinase | 0.0088 | 0.0013 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.1066 | 1 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0088 | 0.0013 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0088 | 0.0013 | 1 |
Echinococcus granulosus | casein kinase I delta | 0.0088 | 0.0013 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.0013 | 1 | |
Mycobacterium ulcerans | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0907 | 1 | 0.5 |
Toxoplasma gondii | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.0907 | 1 | 1 |
Treponema pallidum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0907 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras | 0.0218 | 0.1604 | 0.5 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0907 | 1 | 1 |
Echinococcus granulosus | casein kinase i | 0.0088 | 0.0013 | 0.5 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.0088 | 0.0013 | 1 |
Echinococcus multilocularis | casein kinase I alpha | 0.0088 | 0.0013 | 0.5 |
Leishmania major | casein kinase, putative | 0.0088 | 0.0013 | 0.5 |
Trypanosoma brucei | casein kinase I, isoform 2 | 0.0088 | 0.0013 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-D protein kinase | 0.0088 | 0.0013 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.0088 | 0.0013 | 0.5 |
Brugia malayi | casein kinase I | 0.0088 | 0.0013 | 0.5 |
Echinococcus granulosus | casein kinase I delta | 0.0088 | 0.0013 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.0907 | 1 | 1 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS | 0.0907 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.0088 | 0.0013 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.0088 | 0.0013 | 0.5 |
Echinococcus multilocularis | casein kinase i | 0.0088 | 0.0013 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0088 | 0.0013 | 0.5 |
Echinococcus multilocularis | casein kinase I delta | 0.0088 | 0.0013 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 nM | In vitro activity against human renin (pH 6.0) | ChEMBL. | 1588555 |
IC50 (binding) | = 17 nM | In vitro activity against human renin (pH 6.0) | ChEMBL. | 1588555 |
IC50 (binding) | = 79 nM | In vitro potency against human plasma renin at a pH of 7.4 | ChEMBL. | 1588555 |
IC50 (binding) | = 79 nM | In vitro potency against human plasma renin at a pH of 7.4 | ChEMBL. | 1588555 |
logD (ADMET) | = 3.7 | Partition coefficient (logD6.5) | ChEMBL. | 1588555 |
logD (ADMET) | > 50 | Partition coefficient (logD7.4) | ChEMBL. | 1588555 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.