Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neurokinin 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | neuropeptide F-like receptor | Neurokinin 1 receptor | 407 aa | 333 aa | 21.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Neurokinin 1 receptor | 407 aa | 373 aa | 22.8 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Neurokinin 1 receptor | 407 aa | 342 aa | 22.2 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Neurokinin 1 receptor | 407 aa | 341 aa | 22.0 % |
Echinococcus granulosus | allatostatin A receptor | Neurokinin 1 receptor | 407 aa | 347 aa | 24.8 % |
Echinococcus multilocularis | allatostatin A receptor | Neurokinin 1 receptor | 407 aa | 347 aa | 24.8 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Neurokinin 1 receptor | 407 aa | 387 aa | 18.1 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Neurokinin 1 receptor | 407 aa | 352 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0148 | 0.7743 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0167 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0167 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0167 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0083 | 0 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0103 | 0.2407 | 0.1971 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0167 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0167 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0103 | 0.2407 | 0.1971 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0167 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0167 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0103 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0167 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0167 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0167 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0167 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0103 | 0.2407 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0148 | 0.7743 | 0.7614 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0167 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0167 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0084 | 0.0151 | 0.0151 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0148 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0083 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0167 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0167 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 850 nM | Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand | ChEMBL. | 1851847 |
IC50 (binding) | = 850 nM | Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand | ChEMBL. | 1851847 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.