Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.1324 | 0.1324 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0112 | 0.562 | 0.562 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0112 | 0.562 | 1 |
Onchocerca volvulus | 0.0112 | 0.562 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.562 | 0.562 |
Brugia malayi | cathepsin L-like precursor | 0.0076 | 0.1788 | 0.1788 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0076 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0072 | 0.1324 | 0.2356 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0153 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0072 | 0.1324 | 0.2356 |
Echinococcus granulosus | cathepsin b | 0.0153 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0153 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0064 | 0.0446 | 0.0794 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.562 | 0.562 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0112 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0072 | 0.1324 | 0.1324 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0112 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0112 | 0.562 | 0.562 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0112 | 0.562 | 1 |
Onchocerca volvulus | 0.0076 | 0.1788 | 0.108 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0064 | 0.0446 | 0.0794 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0072 | 0.1324 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0112 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0112 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.562 | 0.5415 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.1324 | 0.2356 |
Onchocerca volvulus | 0.0112 | 0.562 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0112 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Onchocerca volvulus | 0.0112 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.562 | 0.562 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0072 | 0.1324 | 0.1324 |
Plasmodium vivax | vivapain-2 | 0.0112 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.562 | 0.562 |
Onchocerca volvulus | Cathepsin L homolog | 0.0112 | 0.562 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0112 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0112 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.562 | 0.562 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0072 | 0.1324 | 0.1324 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0072 | 0.1324 | 0.1324 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0112 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0072 | 0.1324 | 0.1324 |
Brugia malayi | Cathepsin L-like precursor | 0.0076 | 0.1788 | 0.1788 |
Onchocerca volvulus | 0.0112 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0072 | 0.1324 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.1324 | 0.2356 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0076 | 0.1788 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.1324 | 0.2356 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0112 | 0.562 | 0.5415 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0153 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0153 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0072 | 0.1324 | 0.1697 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0153 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0112 | 0.562 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0112 | 0.562 | 0.5415 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.1324 | 0.2356 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0153 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0076 | 0.1788 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0064 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | ctsf protein | 0.0112 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Echinococcus granulosus | cathepsin b | 0.0153 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1788 | 0.1405 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.0112 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Onchocerca volvulus | 0.0112 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.562 | 0.562 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0112 | 0.562 | 0.562 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0064 | 0.0446 | 0.0446 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1788 | 0.1405 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0112 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1788 | 0.1405 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Onchocerca volvulus | 0.0112 | 0.562 | 1 | |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.1324 | 0.1324 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0076 | 0.1788 | 0.1788 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0072 | 0.1324 | 0.1697 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0072 | 0.1324 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0076 | 0.1788 | 0.1788 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0072 | 0.1324 | 0.1697 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0112 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.0112 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0076 | 0.1788 | 0.1788 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0112 | 0.562 | 0.562 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0072 | 0.1324 | 0.1324 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.562 | 0.562 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0112 | 0.562 | 0.5415 |
Onchocerca volvulus | Cathepsin F homolog | 0.0112 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0112 | 0.562 | 0.562 |
Leishmania major | cysteine peptidase A (CPA) | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0112 | 0.562 | 0.562 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0072 | 0.1324 | 0.2356 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0153 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0112 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1324 | 0.0919 |
Loa Loa (eye worm) | fibroinase | 0.0112 | 0.562 | 0.5415 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0076 | 0.1788 | 0.3182 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0112 | 0.562 | 0.562 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0072 | 0.1324 | 0.1324 |
Onchocerca volvulus | 0.0112 | 0.562 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0076 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.562 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative IC50 (functional) | > 1000 | Inhibition of LPS-induced mouse B-lymphocyte proliferation in relation to IC50 of all-trans retinoic acid. | ChEMBL. | 12067552 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.