Detailed information for compound 754817

Basic information

Technical information
  • TDR Targets ID: 754817
  • Name: N-(2-methoxydibenzofuran-3-yl)-4-nitrobenzami de
  • MW: 362.336 | Formula: C20H14N2O5
  • H donors: 1 H acceptors: 3 LogP: 4.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1NC(=O)c1ccc(cc1)[N+](=O)[O-])oc1c2cccc1
  • InChi: 1S/C20H14N2O5/c1-26-19-10-15-14-4-2-3-5-17(14)27-18(15)11-16(19)21-20(23)12-6-8-13(9-7-12)22(24)25/h2-11H,1H3,(H,21,23)
  • InChiKey: WMMVDYLFHPERCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-methoxydibenzofuran-3-yl)-4-nitro-benzamide
  • N-(2-methoxy-3-dibenzofuranyl)-4-nitrobenzamide
  • Oprea1_332095
  • A0691/0032231
  • EU-0050501
  • ZINC03567032

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.0047 0.128 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2606
Mycobacterium ulcerans hypothetical protein 0.0081 0.2286 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0222 0.0368
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2756
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1762 0.2861
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.3098 0.8837
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0353 0.0542
Leishmania major hypothetical protein, conserved 0.0006 0.0026 0.0203
Echinococcus granulosus tar DNA binding protein 0.0064 0.1762 0.1741
Giardia lamblia O-linked GlcNAc transferase 0.012 0.345 0.5492
Echinococcus granulosus stress induced phosphoprotein 1 0.0006 0.0047 0.0022
Toxoplasma gondii thioredoxin reductase 0.0047 0.128 0.2073
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.128 0.1257
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.3098 0.8837
Giardia lamblia O-linked GlcNAc transferase 0.0205 0.5993 1
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0081 0.2286 0.9999
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.128 0.2985
Brugia malayi glutathione reductase 0.0047 0.128 0.2119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2606
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0353 0.2606
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1762 0.2876
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2756
Echinococcus multilocularis O glycosyltransferase 0.0207 0.6062 0.6051
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0205 0.5993 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.128 1
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0207 0.604 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0353 0.2606
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.3098 0.8837
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1762 0.2917
Mycobacterium tuberculosis Probable reductase 0.0108 0.3098 0.8837
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.3459 1
Plasmodium falciparum glutathione reductase 0.0047 0.128 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0353 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1762 0.2876
Loa Loa (eye worm) RNA binding protein 0.0064 0.1762 0.2861
Echinococcus granulosus O glycosyltransferase 0.0207 0.6062 0.6051
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.128 0.1257
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0222 0.0368
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0353 0.0584
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0353 0.2606
Brugia malayi RNA binding protein 0.0064 0.1762 0.2917
Treponema pallidum hypothetical protein 0.0081 0.2286 0.9999
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0207 0.6062 1
Leishmania major trypanothione reductase 0.0047 0.128 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0353 0.2756
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2606
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0353 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0353 0.0514
Brugia malayi TAR-binding protein 0.0064 0.1762 0.2917
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1762 0.2876
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0353 0.2606
Onchocerca volvulus 0.0006 0.0026 0.0193
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0353 0.2606
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.128 0.2057
Onchocerca volvulus 0.005 0.1345 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0353 0.2756
Treponema pallidum hypothetical protein 0.0081 0.2286 0.9999
Entamoeba histolytica TPR repeat protein 0.0006 0.0026 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.3098 0.8837
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0353 0.2606
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2606
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1762 0.2876
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1762 0.2876
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0353 0.0328
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0353 0.2606
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.3459 1
Echinococcus multilocularis stress induced phosphoprotein 1 0.0006 0.0047 0.0022
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0353 0.2606
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0353 0.2606
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0207 0.604 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0353 0.0328
Plasmodium falciparum glutathione reductase 0.0016 0.0353 0.2606
Trichomonas vaginalis chaperone binding protein, putative 0.0006 0.0026 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.005 0.1345 0.2186
Brugia malayi Thioredoxin reductase 0.0047 0.128 0.2119
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0353 0.2606
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.3459 1
Trypanosoma brucei trypanothione reductase 0.0047 0.128 1
Treponema pallidum hypothetical protein 0.0081 0.2286 0.9999
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.3459 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2606
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.3098 0.8837
Plasmodium vivax glutathione reductase, putative 0.0047 0.128 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0353 0.2606
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0353 0.2606
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.128 1
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0353 0.0514
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1762 0.2861
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0081 0.2286 1
Chlamydia trachomatis hypothetical protein 0.0081 0.2286 1
Loa Loa (eye worm) hypothetical protein 0.005 0.1345 0.2165
Treponema pallidum hypothetical protein 0.0081 0.2286 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0353 0.2606
Loa Loa (eye worm) glutathione reductase 0.0047 0.128 0.2057
Echinococcus multilocularis tumor protein p63 0.0339 1 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1762 0.1741

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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