Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0226 | 0.1338 | 0.1338 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0188 | 0.1023 | 0.0914 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0192 | 0.1054 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0194 | 0.1072 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.1929 | 1 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0404 | 0.2837 | 0.5994 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0603 | 0.4514 | 0.9537 |
Toxoplasma gondii | melibiase subfamily protein | 0.0091 | 0.0205 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0603 | 0.4514 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.1929 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0603 | 0.4514 | 0.9537 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0296 | 0.1929 | 0.4002 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0296 | 0.1929 | 0.1929 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0091 | 0.0205 | 0.0432 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.1072 | 0.5026 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.1072 | 0.5026 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0404 | 0.2837 | 0.5994 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.1072 | 0.5026 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0603 | 0.4514 | 0.4514 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.116 | 0.5537 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0419 | 0.2962 | 0.6398 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.116 | 0.5537 |
Schistosoma mansoni | alpha-glucosidase | 0.0603 | 0.4514 | 0.9516 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.1929 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0603 | 0.4514 | 0.9516 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.1072 | 0.5026 |
Loa Loa (eye worm) | TK protein kinase | 0.0419 | 0.2962 | 0.2962 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0091 | 0.0205 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0205 | 0.0205 |
Onchocerca volvulus | 0.0405 | 0.2848 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.1929 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0226 | 0.1338 | 0.263 |
Loa Loa (eye worm) | hypothetical protein | 0.0629 | 0.4733 | 0.4733 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0404 | 0.2837 | 0.5994 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.1072 | 0.5026 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0091 | 0.0205 | 0.0432 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0603 | 0.4514 | 0.9537 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.1072 | 0.5026 |
Schistosoma mansoni | beta-galactosidase | 0.0629 | 0.4733 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0404 | 0.2837 | 0.5812 |
Echinococcus granulosus | beta galactosidase | 0.0629 | 0.4733 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.0629 | 0.4733 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0192 | 0.1054 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.1072 | 0.5026 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.1929 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.1929 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0404 | 0.2837 | 0.5994 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 100 % | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition | ChEMBL. | 23850103 |
MIC (functional) | = 6.25 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv isonicotinic acid hydrazideresistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 6.25 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv isonicotinic acid hydrazideresistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv streptomycin resistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv kanamycin resistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium kansasii | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium intracellulare. | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv streptomycin resistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv kanamycin resistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition | ChEMBL. | 23850103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.