Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aldehyde dehydrogenase family, putative | 0.02 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase (NAD+) dependent | 0.02 | 1 | 1 |
Echinococcus multilocularis | Fatty aldehyde dehydrogenase | 0.02 | 1 | 1 |
Entamoeba histolytica | aldehyde dehydrogenase 1, putative | 0.02 | 1 | 0.5 |
Loa Loa (eye worm) | aldehyde dehydrogenase 4 | 0.02 | 1 | 0.5 |
Echinococcus granulosus | ras gtp binding protein rho1 | 0.0167 | 0.2884 | 0.2884 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0154 | 0 | 0.5 |
Trypanosoma brucei | aldehyde dehydrogenase family, putative | 0.02 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT | 0.02 | 1 | 0.5 |
Echinococcus granulosus | Fatty aldehyde dehydrogenase | 0.02 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.02 | 1 | 1 |
Onchocerca volvulus | Aldehyde dehydrogenase homolog | 0.02 | 1 | 0.5 |
Trypanosoma cruzi | aldehyde dehydrogenase family, putative | 0.02 | 1 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0154 | 0 | 0.5 |
Echinococcus multilocularis | ras gtp binding protein rho1 | 0.0167 | 0.2884 | 0.2884 |
Mycobacterium ulcerans | aldehyde dehydrogenase (NAD+) dependent | 0.02 | 1 | 1 |
Trichomonas vaginalis | succinate semialdehyde dehydrogenase, putative | 0.02 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase family 3 member B1 | 0.02 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase family 3 member B1 | 0.02 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.