Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2471 | 0.378 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0235 | 0.3177 | 0.6202 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0287 | 0.4319 | 0.7507 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0547 | 1 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0324 | 0.5122 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0223 | 0.2921 | 0.3169 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0324 | 0.5122 | 1 |
Onchocerca volvulus | 0.0307 | 0.4743 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0302 | 0.4644 | 0.9067 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0141 | 0.1128 | 0.1726 |
Schistosoma mansoni | atypical protein kinase C | 0.0262 | 0.377 | 0.736 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0324 | 0.5122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.4743 | 0.7257 |
Echinococcus multilocularis | protein kinase c iota type | 0.0255 | 0.3623 | 0.7074 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0131 | 0.0921 | 0.1799 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.2714 | 0.4153 |
Onchocerca volvulus | 0.0202 | 0.2471 | 0.5209 | |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0183 | 0.2047 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.6521 | 0.9976 |
Echinococcus multilocularis | serine threonine protein kinase | 0.022 | 0.2851 | 0.5566 |
Echinococcus granulosus | protein kinase c iota type | 0.0255 | 0.3623 | 0.7074 |
Onchocerca volvulus | 0.0285 | 0.4264 | 0.8989 | |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0547 | 1 | 0.5 |
Brugia malayi | C1-like domain containing protein | 0.0287 | 0.4319 | 0.7507 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.4743 | 0.7257 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0547 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.4743 | 0.7257 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.4413 | 0.6751 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0921 | 0.141 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0205 | 0.2526 | 0.3864 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0131 | 0.0921 | 0.1799 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0302 | 0.4644 | 0.9067 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0324 | 0.5122 | 0.7836 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0156 | 0.1454 | 0.2838 |
Schistosoma mansoni | protein kinase C mu | 0.0287 | 0.4319 | 0.8432 |
Echinococcus granulosus | protein kinase C gamma type | 0.022 | 0.2851 | 0.5566 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0302 | 0.4644 | 0.9067 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0287 | 0.4319 | 0.6607 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0131 | 0.0921 | 0.1799 |
Onchocerca volvulus | 0.0291 | 0.4413 | 0.9303 | |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2471 | 0.378 |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.6536 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0302 | 0.4644 | 0.9067 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0163 | 0.1603 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.4264 | 0.6523 |
Brugia malayi | protein kinase C II. | 0.0324 | 0.5122 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv isonicotinic acid hydrazideresistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 6.25 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv isonicotinic acid hydrazideresistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv streptomycin resistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv kanamycin resistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium kansasii | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium intracellulare. | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv streptomycin resistant strain | ChEMBL. | 3934384 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv kanamycin resistant strain | ChEMBL. | 3934384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.