Detailed information for compound 760477

Basic information

Technical information
  • TDR Targets ID: 760477
  • Name: N-[(3,4-dimethoxyphenyl)methyl]-N-(1,1-dioxot hiolan-3-yl)-4-prop-2-enoxybenzamide
  • MW: 445.529 | Formula: C23H27NO6S
  • H donors: 0 H acceptors: 3 LogP: 3.01 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1ccc(cc1)C(=O)N(C1CCS(=O)(=O)C1)Cc1ccc(c(c1)OC)OC
  • InChi: 1S/C23H27NO6S/c1-4-12-30-20-8-6-18(7-9-20)23(25)24(19-11-13-31(26,27)16-19)15-17-5-10-21(28-2)22(14-17)29-3/h4-10,14,19H,1,11-13,15-16H2,2-3H3
  • InChiKey: DDXVVDJYELPWOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-allyloxy-N-[(3,4-dimethoxyphenyl)methyl]-N-(1,1-dioxothiolan-3-yl)benzamide
  • 4-allyloxy-N-[(3,4-dimethoxyphenyl)methyl]-N-(1,1-dioxo-3-thiolanyl)benzamide
  • 4-allyloxy-N-(1,1-diketothiolan-3-yl)-N-(3,4-dimethoxybenzyl)benzamide
  • N-[(3,4-dimethoxyphenyl)methyl]-N-(1,1-dioxothiolan-3-yl)-4-prop-2-enoxy-benzamide
  • STOCK3S-99913

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0132 0.2664 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0765
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0445 0.0617
Schistosoma mansoni nAChR subunit 0.0061 0.1068 0.3912
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1068 0.1604
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0132 0.2664 0.4102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0132 0.2664 0.4102
Plasmodium falciparum proline--tRNA ligase 0.0038 0.055 0.051
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 1
Schistosoma mansoni nAChR subunit 0.0132 0.2664 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0454 0.8107
Brugia malayi Cation transporter family protein 0.0132 0.2664 0.4102
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0132 0.2664 0.4102
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2128 0.7955
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.0043
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0061 0.1068 0.3912
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0132 0.2664 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Schistosoma mansoni neurotransmitter gated ion channel 0.0061 0.1068 0.3912
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.2128 0.7955
Echinococcus granulosus glycine receptor subunit alpha 1 0.0132 0.2664 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0445 0.0404
Brugia malayi Sugar transporter family protein 0.0108 0.2128 0.3263
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Echinococcus granulosus nAChR subunit 0.0071 0.1297 0.4787
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0043
Brugia malayi hypothetical protein 0.0061 0.1068 0.1604
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0132 0.2664 0.2722
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0765
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0454 0.1973
Onchocerca volvulus 0.0061 0.1068 0.3912
Echinococcus multilocularis glycine receptor subunit beta 0.0132 0.2664 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.055 1
Loa Loa (eye worm) sugar transporter 0.0108 0.2128 0.2174
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0132 0.2664 0.4102
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0444 0.0454
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1475
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0454 0.1973
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1475
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0445 0.0404
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0132 0.2664 1
Echinococcus granulosus glycine receptor subunit beta 0.0132 0.2664 1
Trypanosoma cruzi hexose transporter 0.0034 0.0454 0.8107
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0132 0.2664 0.4102
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0444 0.7919
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1533
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0243 0.0961
Plasmodium vivax CDK-related protein kinase 6, putative 0.0459 1 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0061 0.1068 0.3912
Leishmania major glucose transporter, lmgt2 0.0034 0.0454 0.8107
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0454 0.1973
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0132 0.2664 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0132 0.2664 0.2722
Brugia malayi hypothetical protein 0.0061 0.1068 0.1604
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 0.191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Onchocerca volvulus Putative nachr subunit 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0061 0.1068 0.3912
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0132 0.2664 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0445 0.0404
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0132 0.2664 1
Loa Loa (eye worm) ACC-1 protein 0.0132 0.2664 0.2722
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0243 0.0201
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0444 0.0629
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.03 0.6434 1
Onchocerca volvulus 0.0061 0.1068 0.3912
Trypanosoma brucei glucose transporter 2A 0.0034 0.0454 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0445 0.0617
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0132 0.2664 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0454 0.8107
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0243 0.0765
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0243 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0243 0.395
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0132 0.2664 1
Schistosoma mansoni nAChR subunit 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Plasmodium falciparum protein kinase 7 0.0306 0.6557 0.6542
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1068 0.1604
Onchocerca volvulus 0.0132 0.2664 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1533
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0071 0.1297 0.1963
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0243 0.0308
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1767
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0132 0.2664 0.4102
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0161 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0132 0.2664 1
Schistosoma mansoni nAChR subunit 0.0132 0.2664 1
Echinococcus granulosus General substrate transporter 0.0093 0.1787 0.6653
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0071 0.1297 0.1963
Plasmodium falciparum mitogen-activated protein kinase 2 0.0175 0.3622 0.3595
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0061 0.1068 0.1604
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0299
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.055 0.051
Brugia malayi excitatory GABA receptor EXP-1A 0.0132 0.2664 0.4102
Onchocerca volvulus 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.03 0.6434 0.6575
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0132 0.2664 1
Leishmania major glucose transporter, lmgt3 0.0034 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Echinococcus granulosus glycine receptor subunit alpha 1 0.0132 0.2664 1
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0454 0.1973
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0061 0.1068 0.3912
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0071 0.1297 0.1963
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0454 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0061 0.1068 0.1091
Echinococcus multilocularis nAChR subunit 0.0071 0.1297 0.4787
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0243 0.0765
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0061 0.1068 0.3912
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0132 0.2664 0.4102
Toxoplasma gondii protein kinase, putative 0.0306 0.6557 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.055 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0444 0.1533
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Schistosoma mansoni nAChR subunit 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Entamoeba histolytica hypothetical protein 0.0071 0.1297 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0445 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.7955
Loa Loa (eye worm) hypothetical protein 0.0033 0.0444 0.0454
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0071 0.1297 0.4787
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0071 0.1297 0.4787
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2128 0.7955
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.7955
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0161 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0132 0.2664 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1068 0.1604
Leishmania major glucose transporter, lmgt1 0.0034 0.0454 0.8107
Onchocerca volvulus 0.0061 0.1068 0.3912
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0061 0.1068 0.3912
Leishmania major protein kinase, putative 0.0033 0.0444 0.7919
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.055 1
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.2128 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0042 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0132 0.2664 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.2664 0.4102
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1533
Brugia malayi hypothetical protein 0.0061 0.1068 0.1604
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0132 0.2664 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0444 0.1533
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0132 0.2664 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1475
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0605
Schistosoma mansoni hypothetical protein 0.0108 0.2128 0.7955
Trypanosoma brucei glucose transporter 1E 0.0034 0.0454 0.8107
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0454 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.1383
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0398 0.1358
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Schistosoma mansoni nAChR subunit 0.0132 0.2664 1
Brugia malayi Cam kinase protein 1 0.0033 0.0444 0.0629
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0429 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0243 0.395
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0444 0.1927
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0454 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.055 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0132 0.2664 1
Schistosoma mansoni glucose transport protein 0.0108 0.2128 0.7955
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1533
Onchocerca volvulus 0.0132 0.2664 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Schistosoma mansoni glucose transport protein 0.0108 0.2128 0.7955
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0445 0.0404
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0132 0.2664 0.4102
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0071 0.1297 0.1963
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0439
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0454 0.1973
Schistosoma mansoni nAChR subunit 0.0132 0.2664 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2128 0.7955
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0132 0.2664 1
Brugia malayi hypothetical protein 0.0061 0.1068 0.1604
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0243 0.0314
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0243 0.395
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1533
Echinococcus multilocularis glycine receptor subunit beta 0.0132 0.2664 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0061 0.1068 0.3912
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0605
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1533
Loa Loa (eye worm) ACC-1 protein 0.0132 0.2664 0.2722
Schistosoma mansoni acetylcholine receptor-related 0.0061 0.1068 0.3912
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0243 0.5182
Onchocerca volvulus 0.0071 0.1297 0.4787
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1533
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0248
Schistosoma mansoni nAChR subunit 0.0061 0.1068 0.3912
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0444 0.0454
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1855
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0132 0.2664 0.2722
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Loa Loa (eye worm) hypothetical protein 0.0239 0.5067 0.5179
Plasmodium falciparum hexose transporter 0.0108 0.2128 0.2094
Schistosoma mansoni nAChR subunit 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.2664 0.4102
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1533
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0061 0.1068 0.1604
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0398 0.1358
Echinococcus multilocularis General substrate transporter 0.0093 0.1787 0.6653
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.2128 0.3201
Brugia malayi hypothetical protein 0.0061 0.1068 0.1604
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1533
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1326
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0243 0.3046
Brugia malayi Cation transporter family protein 0.0132 0.2664 0.4102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0132 0.2664 0.4102
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0132 0.2664 0.4102
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0132 0.2664 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.2664 0.4102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0132 0.2664 0.4102
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.7955
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0043
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0132 0.2664 0.2722
Echinococcus granulosus glycine receptor subunit alpha 1 0.0132 0.2664 1
Echinococcus granulosus nAChR subunit 0.0132 0.2664 1
Onchocerca volvulus 0.0132 0.2664 1
Plasmodium vivax hexose transporter 0.0108 0.2128 0.2094
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.055 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0132 0.2664 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1475
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0175 0.3622 0.5495
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0132 0.2664 0.4102
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0043
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0132 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0439
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Echinococcus multilocularis nAChR subunit 0.0132 0.2664 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0132 0.2664 0.2722
Loa Loa (eye worm) hypothetical protein 0.045 0.9785 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0175 0.3622 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0454 0.1973
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0454 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.7955
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0132 0.2664 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0445 0.0404
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0243 0.0201
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0445 0.0617
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0132 0.2664 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0071 0.1297 0.4787
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0061 0.1068 0.1604
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0429 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0445 0.0404
Onchocerca volvulus 0.0132 0.2664 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.055 0.0779
Onchocerca volvulus 0.0071 0.1297 0.4787
Loa Loa (eye worm) GABA receptor subunit 0.0071 0.1297 0.1326
Loa Loa (eye worm) hypothetical protein 0.0132 0.2664 0.2722
Loa Loa (eye worm) acetylcholine receptor protein 0.0061 0.1068 0.1091
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1533
Brugia malayi Cation transporter family protein 0.0132 0.2664 0.4102
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0132 0.2664 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0132 0.2664 0.2722
Onchocerca volvulus 0.0132 0.2664 1
Echinococcus granulosus glycine receptor subunit beta 0.0132 0.2664 1
Schistosoma mansoni glucose transport protein 0.0108 0.2128 0.7955
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 0.191
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0061 0.1068 0.1091
Trypanosoma brucei glucose transporter, putative 0.0034 0.0454 0.8107
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0061 0.1068 0.1091
Loa Loa (eye worm) LGC-31 protein 0.0132 0.2664 0.2722
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0176 0.0641

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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