Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.0493 | 0.1735 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4409 | 0.4621 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 1 |
Brugia malayi | hypothetical protein | 0.0118 | 0.1228 | 0.2786 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.1464 | 0.1535 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0679 | 0.9541 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0097 | 0.0917 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.1228 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0097 | 0.0917 | 0.7468 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.0917 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4409 | 0.4621 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.1228 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0118 | 0.1228 | 0.1228 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0097 | 0.0917 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4409 | 0.4621 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.185 | 0.4195 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0917 | 0.208 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.1316 | 0.138 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.1519 | 0.1592 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0 | 1 |
Brugia malayi | RNA binding protein | 0.0333 | 0.4409 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0552 | 0.1252 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.0493 | 0.1735 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0097 | 0.0917 | 0.7468 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.0917 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.1464 | 0.1535 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.185 | 0.185 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0097 | 0.0917 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0118 | 0.1228 | 0.1287 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0073 | 0.0552 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.0917 | 0.208 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0679 | 0.9541 | 0.9541 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4409 | 0.4621 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2841 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4409 | 0.4621 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0552 | 0.1252 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.185 | 0.4195 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0073 | 0.0552 | 0.1943 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0917 | 0.208 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0333 | 0.4409 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.1316 | 0.1316 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0679 | 0.9541 | 0.9541 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0104 | 0.1014 | 0.1062 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0073 | 0.0552 | 0.6019 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0097 | 0.0917 | 0.3228 |
Echinococcus multilocularis | tumor protein p63 | 0.071 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.185 | 0.185 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0333 | 0.4409 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0097 | 0.0917 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0118 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0917 | 0.208 |
Brugia malayi | TAR-binding protein | 0.0333 | 0.4409 | 1 |
Onchocerca volvulus | 0.0104 | 0.1014 | 1 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.0917 | 0.208 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0097 | 0.0917 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0097 | 0.0917 | 0.7468 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0073 | 0.0552 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.1228 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.1228 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0097 | 0.0917 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.1316 | 0.1316 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0552 | 0.1252 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0333 | 0.4409 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0073 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0097 | 0.0917 | 0.3228 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.0917 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.0917 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0552 | 0.1252 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.0917 | 0.208 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1014 | 0.2299 |
Onchocerca volvulus | 0.0093 | 0.0847 | 0.8361 | |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.1519 | 0.1592 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.1464 | 0.1464 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0552 | 0.1252 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.0917 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.0493 | 0.1735 |
Loa Loa (eye worm) | RNA binding protein | 0.0333 | 0.4409 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0333 | 0.4409 | 0.4409 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0097 | 0.0917 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.0493 | 0.1735 |
Echinococcus granulosus | tar DNA binding protein | 0.0333 | 0.4409 | 0.4409 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.185 | 0.185 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.1228 | 0.1287 |
Onchocerca volvulus | 0.0097 | 0.0917 | 0.905 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.0917 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.