TDR Targets

Basic information

Technical information

TDR Targets ID: 761638
Name: 2-(4-chlorophenyl)-5-[(4-ethylphenyl)methylid ene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
MW: 371.884 | Formula: C19H18ClN3OS
H donors: 0 H acceptors: 3 LogP: 5.75 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)C=C1SC2N(C1=O)NC(N2)c1ccc(cc1)Cl
InChi: 1S/C19H14ClN3OS/c1-2-12-3-5-13(6-4-12)11-16-18(24)23-19(25-16)21-17(22-23)14-7-9-15(20)10-8-14/h3-11H,2H2,1H3/b16-11-
InChiKey: UYZSDHVCRGTWPP-WJDWOHSUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-2-(4-chlorophenyl)-5-[(4-ethylphenyl)methylidene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
2-(4-chlorophenyl)-5-[(4-ethylphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
(5Z)-2-(4-chlorophenyl)-5-[(4-ethylphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
2-(4-chlorophenyl)-5-[(4-ethylphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
(5Z)-2-(4-chlorophenyl)-5-[(4-ethylphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
(5Z)-2-(4-chlorophenyl)-5-(4-ethylbenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one
2-(4-chlorophenyl)-5-(4-ethylbenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0068	0.1643	0.148
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0012	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0655	0.2507
Loa Loa (eye worm)	hypothetical protein	0.003	0.0254	0.0243
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0012	0.5
Echinococcus granulosus	chromobox protein 1	0.0068	0.1627	0.1464
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0012	0.0238
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0483	0.2938
Brugia malayi	Importin beta-1 subunit	0.0028	0.0192	0.0357
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1405	0.1237
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0483	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0483	0.2938
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0483	0.2938
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0012	0.5
Onchocerca volvulus		0.0094	0.2579	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0012	0.5
Schistosoma mansoni	hypothetical protein	0.0299	1	1
Echinococcus multilocularis	chromobox protein 1	0.0068	0.1627	0.1464
Brugia malayi	RNA, U transporter 1	0.008	0.2061	0.4061
Brugia malayi	TAR-binding protein	0.0062	0.1405	0.2761
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0483	1
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.1301	0.1131
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0012	0.5
Brugia malayi	chromobox protein homolog 3	0.0038	0.0551	0.1069
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0192	0.5
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0068	0.1643	0.148
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.015	0.0914
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1405	0.1237
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.2875	0.2735
Echinococcus granulosus	lysosomal alpha glucosidase	0.0163	0.5058	0.4961
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0102	0.2875	0.2735
Trypanosoma brucei	glucosidase, putative	0.0036	0.0483	1
Onchocerca volvulus		0.003	0.0254	0.0946
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0012	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0012	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0376	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0192	0.018
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1643	0.1633
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1405	0.1237
Brugia malayi	Melibiase family protein	0.0068	0.1643	0.3233
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0483	0.2938
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.1301	0.1131
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0483	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0551	0.054
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.1627	0.1618
Brugia malayi	RNA binding protein	0.0062	0.1405	0.2761
Brugia malayi	Heterochromatin protein 1	0.0068	0.1627	0.3202
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0551	0.2101
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0483	0.1085
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1405	0.1237
Echinococcus multilocularis	chromobox protein 1	0.0068	0.1627	0.1464
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0012	0.0238
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0012	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1405	0.1395
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0483	0.0297
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0551	0.3353
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1405	0.1237
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.1301	0.1291
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0483	1
Echinococcus multilocularis	snurportin 1	0.0299	1	1
Schistosoma mansoni	alpha-glucosidase	0.014	0.4239	0.4127
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0931	0.092
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.1627	0.9904
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0483	0.2938
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0102	0.2875	0.2735
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0376	0.0722
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0655	0.3988
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.2875	0.2735
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.5058	0.4961
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0012	0.0238
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0483	1
Schistosoma mansoni	chromobox protein	0.0068	0.1627	0.1464
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1405	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0931	0.092
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0012	0.0238
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1405	0.1237
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.1301	0.1131
Plasmodium falciparum	importin beta, putative	0.0028	0.0192	0.5
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0012	0.0238
Echinococcus granulosus	chromobox protein 1	0.0068	0.1627	0.1464
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0931	0.1821
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0102	0.2875	0.2735
Schistosoma mansoni	hypothetical protein	0.0033	0.0376	0.0188
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0483	0.2938
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0483	0.0934
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.1301	0.1131
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.1301	0.1131
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0012	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1405	0.2761
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.2875	0.2735
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0483	0.2938
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0012	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	1	1
Brugia malayi	jmjC domain containing protein	0.0059	0.1301	0.2554
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.2875	0.2735
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0163	0.5058	1
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1405	0.1237
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.1301	0.1131
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0551	0.3353
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0483	0.0472
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.5058	0.4961
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.015	0.0914
Schistosoma mansoni	alpha glucosidase	0.0036	0.0483	0.0297
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0931	0.1821
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0483	0.2938
Brugia malayi	jmjC domain containing protein	0.0059	0.1301	0.2554
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0012	0.5
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.1301	0.1131
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0012	0.5
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1405	0.1395
Schistosoma mansoni	alpha-glucosidase	0.014	0.4239	0.4127
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.1627	0.9904
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0163	0.5058	0.5052
Toxoplasma gondii	melibiase subfamily protein	0.0102	0.2875	1
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0655	0.3988
Schistosoma mansoni	chromobox protein	0.0068	0.1627	0.1464
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0068	0.1643	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0012	0.5
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0483	0.0297
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0483	0.2938

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 761638