Detailed information for compound 766522

Basic information

Technical information
  • TDR Targets ID: 766522
  • Name: 2-[(2,6-dibromo-4-methylphenyl)amino]-N-[(4-d iethylaminophenyl)methylideneamino]acetamide
  • MW: 496.239 | Formula: C20H24Br2N4O
  • H donors: 2 H acceptors: 1 LogP: 5.49 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)C=NNC(=O)CNc1c(Br)cc(cc1Br)C)CC
  • InChi: 1S/C20H24Br2N4O/c1-4-26(5-2)16-8-6-15(7-9-16)12-24-25-19(27)13-23-20-17(21)10-14(3)11-18(20)22/h6-12,23H,4-5,13H2,1-3H3,(H,25,27)/b24-12+
  • InChiKey: YWCLZHMHKAFQGD-WYMPLXKRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(2,6-dibromo-4-methyl-phenyl)amino]-N-[(4-diethylaminophenyl)methyleneamino]acetamide
  • 2-[(2,6-dibromo-4-methylphenyl)amino]-N-[(4-diethylaminophenyl)methyleneamino]acetamide
  • 2-[(2,6-dibromo-4-methyl-phenyl)amino]-N-[(4-diethylaminobenzylidene)amino]acetamide
  • 2-[(2,6-dibromo-4-methyl-phenyl)amino]-N-[(4-diethylaminophenyl)methylideneamino]ethanamide
  • A0418/0019329

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Putative transporter 0.003 0.0084 0.5
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0484 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0493 0.8107
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0484 0.0404
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0283 1
Entamoeba histolytica protein kinase, putative 0.0064 0.0484 1
Onchocerca volvulus 0.003 0.0084 0.5
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0084 0.2954
Toxoplasma gondii facilitative glucose transporter GT1 0.021 0.216 0.3201
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0283 1
Onchocerca volvulus 0.003 0.0084 0.5
Onchocerca volvulus 0.003 0.0084 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0493 0.1973
Onchocerca volvulus 0.003 0.0084 0.5
Leishmania major protein kinase, putative 0.0064 0.0484 0.7919
Schistosoma mansoni glucose transport protein 0.021 0.216 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0484 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0484 0.1927
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0484 0.2088
Toxoplasma gondii protein kinase, putative 0.0593 0.6571 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0493 0.1973
Leishmania major glucose transporter, lmgt1 0.0065 0.0493 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0493 0.1973
Schistosoma mansoni glucose transport protein 0.021 0.216 1
Plasmodium falciparum protein kinase 7 0.0593 0.6571 0.6542
Schistosoma mansoni protein kinase 0.0064 0.0484 0.1927
Plasmodium falciparum mitogen-activated protein kinase 2 0.0339 0.3649 0.3595
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0589 0.051
Entamoeba histolytica protein kinase, putative 0.0064 0.0484 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0589 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.216 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.021 0.216 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0484 0.1927
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0493 0.1973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.216 1
Echinococcus multilocularis hedgehog 0.0183 0.185 0.8503
Onchocerca volvulus 0.003 0.0084 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0283 0.0201
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0589 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0202 1
Onchocerca volvulus 0.003 0.0084 0.5
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0283 0.3046
Schistosoma mansoni glucose transport protein 0.021 0.216 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0469 0.9253
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0493 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.216 1
Onchocerca volvulus 0.003 0.0084 0.5
Schistosoma mansoni protein kinase 0.0064 0.0484 0.1927
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0484 0.0404
Loa Loa (eye worm) sugar transporter 0.021 0.216 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0484 0.1927
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0084 0.0199
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0589 1
Onchocerca volvulus 0.003 0.0084 0.5
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0589 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0047 0.0283 0.1141
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0589 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0283 0.0961
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0493 0.8107
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0484 0.2088
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0469 0.1855
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1295
Trypanosoma brucei glucose transporter 1E 0.0065 0.0493 0.8107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0283 0.395
Loa Loa (eye worm) hypothetical protein 0.0063 0.0469 0.2017
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0484 0.1927
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0493 0.8107
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0589 0.051
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0469 0.1855
Onchocerca volvulus 0.003 0.0084 0.5
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0469 0.1855
Plasmodium falciparum hexose transporter 0.021 0.216 0.2094
Leishmania major glucose transporter, lmgt3 0.0065 0.0493 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.216 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0484 0.1927
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0084 0.2954
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0484 0.1927
Treponema pallidum prolyl-tRNA synthetase 0.0022 0 0.5
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0283 0.0201
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0202 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0469 0.1855
Brugia malayi Hint module family protein 0.005 0.0316 0.1118
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0084 0.0199
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0484 0.0404
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Trichomonas vaginalis conserved hypothetical protein 0.021 0.216 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0339 0.3649 0.5495
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.216 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0493 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0484 0.1927
Loa Loa (eye worm) hypothetical protein 0.0051 0.0333 0.1375
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0493 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.216 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0484 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0493 0.1973
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0484 0.7919
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0484 0.1927
Plasmodium vivax hexose transporter 0.021 0.216 0.2094
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0283 0.395
Onchocerca volvulus 0.003 0.0084 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0084 0.5
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0283 0.0961
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Mycobacterium ulcerans sugar transporter 0.003 0.0084 0.2954
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0339 0.3649 0.3595
Onchocerca volvulus 0.003 0.0084 0.5
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Loa Loa (eye worm) sugar transporter 0.003 0.0084 0.0199
Brugia malayi Sugar transporter family protein 0.021 0.216 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0589 0.0779
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0283 0.0308
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0283 0.0961
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0283 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0469 0.1855
Schistosoma mansoni hypothetical protein 0.021 0.216 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0484 0.1927
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0493 0.8107
Plasmodium vivax CDK-related protein kinase 6, putative 0.0891 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1295
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Schistosoma mansoni hypothetical protein 0.0133 0.1278 0.5749
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Echinococcus granulosus Desert hedgehog protein 0.0183 0.185 0.8503
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0493 0.1973
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0283 0.0961
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0484 0.0617
Brugia malayi Cam kinase protein 1 0.0064 0.0484 0.1927
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.216 1
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0438 0.1707
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0484 0.0617
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Onchocerca volvulus 0.003 0.0084 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0484 0.2088
Onchocerca volvulus 0.003 0.0084 0.5
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0283 0.0961
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0469 0.1855
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0084 0.2954
Trypanosoma brucei glucose transporter, putative 0.0065 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0063 0.0469 0.2017
Trypanosoma brucei glucose transporter 2A 0.0065 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Onchocerca volvulus 0.003 0.0084 0.5
Trypanosoma cruzi hexose transporter 0.0065 0.0493 0.8107
Brugia malayi Hint module family protein 0.005 0.0316 0.1118
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0493 0.1973
Onchocerca volvulus 0.003 0.0084 0.5
Leishmania major glucose transporter, lmgt2 0.0065 0.0493 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0154 0.1383
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0484 0.0617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0484 0.1927
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0283 0.5182
Echinococcus multilocularis General substrate transporter 0.018 0.1821 0.8364
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0283 0.395
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0283 0.0961
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0217 0.0641
Echinococcus granulosus General substrate transporter 0.018 0.1821 0.8364
Schistosoma mansoni protein kinase 0.0064 0.0484 0.1927
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0484 0.1927
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0484 0.0404
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0484 0.0404
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0469 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0199
Onchocerca volvulus 0.003 0.0084 0.5
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0438 0.1707

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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