TDR Targets

Basic information

Technical information

TDR Targets ID: 767121
Name: STOCK1N-09803
MW: 311.378 | Formula: C18H21N3O2
H donors: 1 H acceptors: 2 LogP: 1.05 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Nc2c(C31N1CC4(CN3CC(C1)(C4=O)C)C)cc(cc2)C
InChi: 1S/C18H21N3O2/c1-11-4-5-13-12(6-11)18(15(23)19-13)20-7-16(2)8-21(18)10-17(3,9-20)14(16)22/h4-6H,7-10H2,1-3H3,(H,19,23)
InChiKey: QDECVVHDLXRULP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.015	0.8559
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0122	0.032	0.1864
Trypanosoma cruzi	metacaspase, putative	0.0051	0.0058	0.3301
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0058	0.0229
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0057	0.0544
Trypanosoma brucei	metacaspase MCA2	0.0051	0.0058	0.3301
Echinococcus granulosus	apoptotic protease activating factor 1	0.0047	0.0045	0.0428
Trypanosoma brucei	trypanothione reductase	0.0053	0.0068	0.3862
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0133	0.0362	0.212
Echinococcus granulosus	protein quaking	0.0061	0.0095	0.0903
Brugia malayi	Niemann-Pick C1 protein precursor	0.0224	0.0698	0.2765
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0082	0.0175	0.5
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0138	0.0381	0.2233
Mycobacterium ulcerans	hypothetical protein	0.0133	0.0362	0.212
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0133	0.0362	0.212
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Echinococcus multilocularis	protein quaking	0.0061	0.0095	0.0095
Brugia malayi	Cell death protein 3 precursor	0.0098	0.0232	0.092
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0057	0.0807
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0066	0.0114	0.1078
Echinococcus granulosus	hypothetical protein	0.0061	0.0095	0.0903
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0082	0.0175	0.4605
Toxoplasma gondii	aldehyde dehydrogenase	0.0138	0.0381	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0099	0.0238	0.5
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0227	0.0711	1
Toxoplasma gondii	thioredoxin reductase	0.0053	0.0068	0.1778
Brugia malayi	CHE-14 protein	0.0096	0.0226	0.0894
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0078	0.0311
Brugia malayi	glutathione reductase	0.0053	0.0068	0.0268
Schistosoma mansoni	aldehyde dehydrogenase	0.0138	0.0381	0.5359
Echinococcus granulosus	caspase 8	0.0051	0.0058	0.055
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0057	0.0057
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0133	0.0362	0.212
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0066	0.0114	0.045
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0099	0.0238	0.1361
Brugia malayi	hypothetical protein	0.0061	0.0095	0.0377
Plasmodium falciparum	metacaspase-like protein	0.0051	0.0058	0.2433
Loa Loa (eye worm)	jmjC domain-containing protein	0.0131	0.0356	0.141
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0482	0.1654	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0122	0.032	0.1864
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.0032	0.0307
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0082	0.0175	0.0458
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.0175	0.4605
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0051	0.0058	0.0815
Trypanosoma brucei	metacaspase 5, putative	0.0051	0.0058	0.3301
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0047	0.0045	0.0045
Echinococcus multilocularis	caspase 2	0.0098	0.0232	0.0232
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0039	0.0015	0.0852
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0039	0.0015	0.0628
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0224	0.0698	0.1949
Echinococcus granulosus	caspase 3	0.0083	0.0179	0.1695
Plasmodium falciparum	acyl-CoA synthetase	0.0099	0.0238	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0135	0.0371	0.217
Trypanosoma cruzi	metacaspase 5, putative	0.0051	0.0058	0.3301
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0076	0.015	0.0595
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0051	0.0058	0.152
Schistosoma mansoni	caspase-7 (C14 family)	0.0134	0.0366	0.5147
Echinococcus multilocularis	caspase 3	0.0083	0.0179	0.0179
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.0068	0.0643
Loa Loa (eye worm)	glutathione reductase	0.0053	0.0068	0.0268
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0094	0.0218	0.1239
Mycobacterium ulcerans	acyl-CoA synthetase	0.0133	0.0362	0.212
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0503	0.1993
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.0175	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0131	0.0356	0.0356
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0138	0.0381	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0059
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0015	0.0852
Leishmania major	trypanothione reductase	0.0053	0.0068	0.1778
Plasmodium falciparum	metacaspase 1	0.0051	0.0058	0.2433
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0015	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0238	0.0943
Brugia malayi	AMP-binding enzyme family protein	0.0039	0.0015	0.0059
Brugia malayi	Thioredoxin reductase	0.0053	0.0068	0.0268
Schistosoma mansoni	hypothetical protein	0.0093	0.0213	0.2994
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0051	0.0058	0.152
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0133	0.0362	0.0991
Brugia malayi	AMP-binding enzyme family protein	0.0039	0.0015	0.0059
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0039	0.0015	0.0852
Trypanosoma cruzi	metacaspase, putative	0.0051	0.0058	0.3301
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0987	0.3521	1
Echinococcus granulosus	muscleblind protein	0.0171	0.0503	0.4778
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0039	0.0015	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0058	0.0123
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0138	0.0381	0.2233
Brugia malayi	AMP-binding enzyme family protein	0.0039	0.0015	0.0059
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0134	0.0366	0.3474
Brugia malayi	AMP-binding enzyme family protein	0.0039	0.0015	0.0059
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0013	0.005
Mycobacterium tuberculosis	Probable dehydrogenase	0.0122	0.032	0.1864
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0058	0.0123
Trypanosoma brucei	Metacaspase-4	0.0051	0.0058	0.3301
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0122	0.032	0.1864
Mycobacterium ulcerans	acyl-CoA synthetase	0.0133	0.0362	0.212
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0306	0.121
Trypanosoma brucei	metacaspase	0.0051	0.0058	0.3301
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0135	0.0371	0.217
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Echinococcus multilocularis	muscleblind protein 1	0.0171	0.0503	0.0503
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0133	0.0362	0.212
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0094	0.0218	0.1239
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0122	0.032	0.1864
Echinococcus granulosus	caspase 2	0.0098	0.0232	0.2207
Schistosoma mansoni	inositol monophosphatase	0.0082	0.0175	0.2467
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0122	0.032	0.1864
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Loa Loa (eye worm)	tumor suppressor	0.0718	0.2525	1
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0058	0.0123
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0078	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0013	0.005
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0061	0.0097	0.0385
Mycobacterium tuberculosis	Probable reductase	0.0122	0.032	0.1864
Plasmodium vivax	metacaspase 1, putative	0.0051	0.0058	0.2433
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0987	0.3521	0.5
Schistosoma mansoni	caspase-3 (C14 family)	0.0134	0.0366	0.5147
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.0068	0.2846
Echinococcus multilocularis	caspase 8	0.0051	0.0058	0.0058
Onchocerca volvulus		0.0133	0.0362	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0039	0.0015	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0362	0.1435
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.0032	0.0032
Brugia malayi	AMP-binding enzyme family protein	0.0133	0.0362	0.1435
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.0114	0.0602
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0099	0.0238	0.1361
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0096	0.0226	0.0894
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.0175	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0135	0.0371	0.217
Onchocerca volvulus		0.0043	0.0031	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0238	0.0943
Brugia malayi	Inositol-1	0.0082	0.0175	0.0695
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0482	0.1654	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0133	0.0362	0.212
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0133	0.0362	0.212
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.0068	0.0322
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0039	0.0015	0.0392
Echinococcus granulosus	Niemann Pick C1 protein	0.032	0.1053	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0098	0.0232	0.3269
Echinococcus granulosus	Protein patched homolog 1	0.0096	0.0226	0.2143
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0362	0.1435
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0082	0.0175	0.0458
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0076	0.015	0.0386
Echinococcus granulosus	expressed conserved protein	0.021	0.0648	0.6152
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0057	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0059
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0133	0.0362	0.212
Leishmania major	acetyl-CoA synthetase, putative	0.0039	0.0015	0.0392
Schistosoma mansoni	hypothetical protein	0.0038	0.0013	0.0178
Echinococcus multilocularis	expressed conserved protein	0.021	0.0648	0.0648
Trypanosoma cruzi	metacaspase 5, putative	0.0051	0.0058	0.3301
Schistosoma mansoni	hypothetical protein	0.0047	0.0045	0.0634
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0076	0.015	0.1425
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0482	0.1654	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0131	0.0356	0.0356
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0131	0.0356	0.5007
Schistosoma mansoni	inositol monophosphatase	0.0082	0.0175	0.2467
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0074	0.0143	0.0784
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0057	0.0227
Loa Loa (eye worm)	oxidoreductase	0.0039	0.0015	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0362	0.1435
Trypanosoma brucei	metacaspase MCA3	0.0051	0.0058	0.3301
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.0068	0.0268
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0039	0.0015	0.0628
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0058	0.0123
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0082	0.0175	0.0458
Trichomonas vaginalis	inositol monophosphatase, putative	0.0082	0.0175	0.0458
Brugia malayi	Muscleblind-like protein	0.0171	0.0503	0.1993
Leishmania major	acetyl-CoA synthetase, putative	0.0039	0.0015	0.0392
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0135	0.0371	0.217
Brugia malayi	AMP-binding enzyme family protein	0.0133	0.0362	0.1435
Echinococcus granulosus	caspase	0.0134	0.0366	0.3474
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0039	0.0015	0.0852
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0076	0.015	0.015
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.0226	0.0601
Brugia malayi	AMP-binding enzyme family protein	0.0133	0.0362	0.1435
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.015	0.8559
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0039	0.0015	0.0392
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0138	0.0381	0.2233
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0058	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0057	0.0227
Loa Loa (eye worm)	inositol-1	0.0082	0.0175	0.0695
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0987	0.3521	1
Schistosoma mansoni	hypothetical protein	0.0093	0.0213	0.2994
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0138	0.0381	0.3617
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0015	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0078	0.0311
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0076	0.015	0.2112
Trypanosoma cruzi	metacaspase, putative	0.0051	0.0058	0.3301
Echinococcus multilocularis	Niemann Pick C1 protein	0.0224	0.0698	0.0698
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0015	0.0392
Onchocerca volvulus	Cell death protein 3 homolog	0.0098	0.0232	0.626
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0232	0.092
Mycobacterium ulcerans	acyl-CoA synthetase	0.0133	0.0362	0.212
Echinococcus granulosus	Niemann Pick C1 protein	0.0224	0.0698	0.6628
Schistosoma mansoni	hypothetical protein	0.0061	0.0095	0.1338
Echinococcus multilocularis	inositol monophosphatase 1	0.0082	0.0175	0.0175
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0057	0.0057
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0133	0.0362	0.0991
Brugia malayi	hypothetical protein	0.0047	0.0045	0.0178
Plasmodium vivax	acyl-CoA synthetase, putative	0.0099	0.0238	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.032	0.1053	0.1053
Brugia malayi	tumor suppressor.	0.0718	0.2525	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.0175	1
Trypanosoma cruzi	metacaspase, putative	0.0051	0.0058	0.3301
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0057	0.0807
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.0068	0.3862
Brugia malayi	Temporarily assigned gene name protein 44	0.0061	0.0095	0.0377
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0039	0.0015	0.0059
Echinococcus granulosus	sterol regulatory element binding protein	0.0096	0.0226	0.2143
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0039	0.0015	0.0059
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0987	0.3521	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0131	0.0356	0.338
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0503	0.1993
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.0114	0.0602
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0066	0.0114	0.298
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0058	0.0123
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.0114	0.0602
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0066	0.0114	0.1597
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.015	0.8559
Echinococcus multilocularis	muscleblind protein	0.0171	0.0503	0.0503
Echinococcus multilocularis	protein dispatched 1	0.011	0.0276	0.0276
Plasmodium falciparum	thioredoxin reductase	0.0053	0.0068	0.2846
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0076	0.015	0.3941
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0094	0.0218	0.1239
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0082	0.0175	0.0979
Entamoeba histolytica	acyl-coA synthetase, putative	0.0133	0.0362	0.0991
Leishmania major	4-coumarate:coa ligase-like protein	0.0133	0.0362	0.9512
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0238	0.0943
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0066	0.0114	0.0114
Schistosoma mansoni	hypothetical protein	0.0061	0.0095	0.1338
Echinococcus granulosus	inositol monophosphatase 1	0.0082	0.0175	0.1665
Schistosoma mansoni	jumonji domain containing protein	0.0131	0.0356	0.5007
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Echinococcus multilocularis	caspase	0.0134	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0045	0.0178
Echinococcus multilocularis	protein patched	0.0096	0.0226	0.0226
Plasmodium falciparum	glutathione reductase	0.0053	0.0068	0.2846
Echinococcus multilocularis	sterol regulatory element binding protein	0.0096	0.0226	0.0226
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0051	0.0058	0.0229
Brugia malayi	jmjC domain containing protein	0.0131	0.0356	0.141
Schistosoma mansoni	aldehyde dehydrogenase	0.0138	0.0381	0.5359
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0131	0.0356	0.5007
Schistosoma mansoni	hypothetical protein	0.0093	0.0213	0.2994
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0698	0.2765
Echinococcus granulosus	lysine specific demethylase 5A	0.0131	0.0356	0.338
Plasmodium vivax	hypothetical protein, conserved	0.0051	0.0058	0.2433
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0226	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0238	0.0943
Leishmania major	4-coumarate:coa ligase-like protein	0.0133	0.0362	0.9512
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0138	0.0381	0.2233
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0133	0.0362	0.212
Leishmania major	4-coumarate:coa ligase-like protein	0.0133	0.0362	0.9512
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0094	0.0218	0.1239
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0039	0.0015	0.0059
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0134	0.0366	0.0366
Giardia lamblia	Fructose-bisphosphate aldolase	0.0987	0.3521	0.5
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0138	0.0381	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0039	0.0015	0.0059
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.0068	0.0068
Leishmania major	metacaspase, putative	0.0051	0.0058	0.152
Schistosoma mansoni	acetyl-CoA synthetase	0.0039	0.0015	0.021
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0074	0.0143	0.0784
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0057	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0238	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0095	0.0377
Brugia malayi	jmjC domain containing protein	0.0131	0.0356	0.141
Onchocerca volvulus		0.0047	0.0045	0.0866
Schistosoma mansoni	hypothetical protein	0.0093	0.0213	0.2994
Toxoplasma gondii	propionate-CoA ligase	0.0039	0.0015	0.0392
Schistosoma mansoni	patched 1	0.0096	0.0226	0.3175
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0051	0.0058	0.0123
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0051	0.0058	0.152
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0078	0.0311
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0076	0.015	0.0595
Plasmodium vivax	glutathione reductase, putative	0.0053	0.0068	0.2846

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 767121