Detailed information for compound 767190

Basic information

Technical information
  • TDR Targets ID: 767190
  • Name: 5-imino-6-[[1-(4-methoxyphenyl)-2,5-dimethylp yrrol-3-yl]methylidene]-[1,3]thiazolo[3,2-a]p yrimidin-7-one
  • MW: 378.448 | Formula: C20H18N4O2S
  • H donors: 0 H acceptors: 1 LogP: 3.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1c(C)cc(c1C)C=C1C(=O)N=c2n(C1=N)ccs2
  • InChi: 1S/C20H18N4O2S/c1-12-10-14(13(2)24(12)15-4-6-16(26-3)7-5-15)11-17-18(21)23-8-9-27-20(23)22-19(17)25/h4-11,21H,1-3H3/b17-11-,21-18?
  • InChiKey: RQNBUFFQKMPEJB-WAHGPNOUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-imino-6-[[1-(4-methoxyphenyl)-2,5-dimethyl-pyrrol-3-yl]methylene]thiazolo[3,2-a]pyrimidin-7-one
  • 5-imino-6-[[1-(4-methoxyphenyl)-2,5-dimethyl-3-pyrrolyl]methylene]-7-thiazolo[3,2-a]pyrimidinone
  • 5-imino-6-[[1-(4-methoxyphenyl)-2,5-dimethyl-pyrrol-3-yl]methylidene]-[1,3]thiazolo[3,2-a]pyrimidin-7-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sodium-bile acid cotransporter related 0.0177 0.397 0.397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0611 0.0611
Schistosoma mansoni sodium-bile acid cotransporter related 0.0436 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.3184 0.3184
Loa Loa (eye worm) hypothetical protein 0.0014 0.0173 0.0173
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0611 0.0611
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0318 0.0544
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.074 0.1267
Plasmodium vivax SET domain protein, putative 0.0032 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0611 0.0611
Echinococcus granulosus lamin dm0 0.0029 0.0539 0.0539
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.3184 0.3184
Echinococcus multilocularis lamin 0.0029 0.0539 0.0539
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0186 0.0186
Schistosoma mansoni inositol monophosphatase 0.0038 0.074 0.074
Onchocerca volvulus 0.0032 0.0611 0.0611
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0318 0.5
Loa Loa (eye worm) inositol-1 0.0038 0.074 0.074
Schistosoma mansoni sodium-bile acid cotransporter 0.0259 0.5887 0.5887
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.3184 0.3184
Schistosoma mansoni ap endonuclease 0.002 0.0318 0.0318
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0186 0.0186
Echinococcus granulosus sodium bile acid cotransporter 0.0436 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.074 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0648 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0173 0.0173
Schistosoma mansoni ap endonuclease 0.002 0.0318 0.0318
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.074 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0539 0.0539
Onchocerca volvulus 0.0029 0.0539 0.0539
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0539 0.0539
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0318 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.074 0.074
Brugia malayi Inositol-1 0.0038 0.074 0.074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.3184 0.3184
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0222 0.0222
Echinococcus multilocularis sodium bile acid cotransporter 0.0436 1 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0648 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0318 0.4293
Onchocerca volvulus 0.0436 1 1
Loa Loa (eye worm) hypothetical protein 0.0436 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0611 0.0611
Echinococcus granulosus sodium bile acid cotransporter 0.0436 1 1
Echinococcus multilocularis musashi 0.0029 0.0539 0.0539
Echinococcus granulosus intermediate filament protein 0.0029 0.0539 0.0539
Echinococcus multilocularis sodium bile acid cotransporter 0.0436 1 1
Brugia malayi Pre-SET motif family protein 0.0226 0.5116 0.5116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0611 0.0611
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.5116 0.5116
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.074 0.1267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.074 0.1267
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0318 0.0318
Schistosoma mansoni lamin 0.0029 0.0539 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.3184 0.3184
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.5203 0.5203
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0186 0.0186
Trichomonas vaginalis set domain proteins, putative 0.0257 0.5843 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0222 0.0222
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0539 0.0539
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.074 1
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.074 0.074
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0318 0.0544
Loa Loa (eye worm) hypothetical protein 0.0029 0.0526 0.0526
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.074 1
Brugia malayi intermediate filament protein 0.0029 0.0539 0.0539
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0611 0.0611
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0539 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.3184 0.3184
Schistosoma mansoni intermediate filament proteins 0.0029 0.0539 0.0539
Onchocerca volvulus 0.0257 0.5843 0.5843
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0611 0.6953
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.3184 0.3184
Brugia malayi Pre-SET motif family protein 0.0032 0.0611 0.0611
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0584 0.0584
Echinococcus multilocularis sodium bile acid cotransporter 0.0436 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.074 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0318 0.5
Schistosoma mansoni lamin 0.0029 0.0539 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0611 0.0611
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.074 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.3184 0.3184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.3184 0.3184
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.074 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.074 0.074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0318 0.0318
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0318 0.0318
Echinococcus granulosus sodium bile acid cotransporter 0.0436 1 1
Brugia malayi follicle stimulating hormone receptor 0.023 0.5203 0.5203
Echinococcus granulosus lamin 0.0029 0.0539 0.0539
Onchocerca volvulus 0.0029 0.0539 0.0539
Echinococcus multilocularis lamin dm0 0.0029 0.0539 0.0539
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.074 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0611 0.0611

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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