Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, receptor type, C | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) | protein tyrosine phosphatase, receptor type, C | 87 aa | 85 aa | 25.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | tyrosinase 1 | 0.0106 | 0.1113 | 0.2342 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0141 | 0.1857 | 0.3908 |
Onchocerca volvulus | 0.0106 | 0.1113 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1113 | 0.2342 |
Onchocerca volvulus | 0.0065 | 0.0249 | 0.2234 | |
Echinococcus multilocularis | jun protein | 0.0097 | 0.0917 | 0.1485 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0278 | 0.4751 | 0.4617 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0278 | 0.4751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4751 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0278 | 0.4751 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0479 | 0.1007 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0097 | 0.0917 | 0.1485 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0106 | 0.1113 | 0.2342 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0085 | 0.0666 | 0.0927 |
Onchocerca volvulus | 0.0076 | 0.0479 | 0.4302 | |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0278 | 0.4751 | 0.4617 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0106 | 0.1113 | 0.2342 |
Onchocerca volvulus | 0.0065 | 0.0249 | 0.2234 | |
Schistosoma mansoni | tyrosinase precursor | 0.0106 | 0.1113 | 0.0886 |
Onchocerca volvulus | 0.0065 | 0.0249 | 0.2234 | |
Brugia malayi | ShTK domain containing protein | 0.0106 | 0.1113 | 0.2342 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0278 | 0.4751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0013 | 0.0027 |
Schistosoma mansoni | jun-related protein | 0.0078 | 0.0535 | 0.0293 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0106 | 0.1113 | 0.2342 |
Schistosoma mansoni | tyrosinase precursor | 0.0106 | 0.1113 | 0.0886 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0535 | 0.0293 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0106 | 0.1113 | 0.2342 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0065 | 0.0249 | 0.2234 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0137 | 0.1769 | 0.3724 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0097 | 0.0917 | 0.1485 |
Onchocerca volvulus | 0.0106 | 0.1113 | 1 | |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0106 | 0.1113 | 0.2342 |
Onchocerca volvulus | 0.0065 | 0.0249 | 0.2234 | |
Echinococcus granulosus | jun protein | 0.0097 | 0.0917 | 0.1485 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0861 | 0.1813 |
Onchocerca volvulus | 0.0106 | 0.1113 | 1 | |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0085 | 0.0666 | 0.0927 |
Onchocerca volvulus | 0.0106 | 0.1113 | 1 | |
Brugia malayi | bZIP transcription factor family protein | 0.0097 | 0.0917 | 0.1931 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0278 | 0.4751 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0106 | 0.1113 | 0.2342 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0106 | 0.1113 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1113 | 0.2342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 3 uM | Cytotoxicity of the compound measured against human T-cells | ChEMBL. | 11356112 |
IC50 (functional) | = 0.2 uM | In vitro inhibition of human T-cell proliferation | ChEMBL. | 11356112 |
IC50 (binding) | = 7.7 uM | In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate | ChEMBL. | 11356112 |
IC50 (binding) | = 7.7 uM | In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate | ChEMBL. | 11356112 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.