Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.07 | 0.07 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.085 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.085 | 0.085 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0349 | 0.0349 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1211 | 0.1211 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.07 | 0.07 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0349 | 0.4983 |
Echinococcus multilocularis | hypothetical protein | 0.0094 | 0.1211 | 0.1211 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.085 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.07 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.07 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1211 | 0.1211 |
Plasmodium falciparum | NLI interacting factor-like phosphatase, putative | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.085 | 0.085 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0095 | 0.1222 | 0.1222 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.07 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0349 | 0.4106 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.07 | 0.824 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0349 | 0.086 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.019 | 0.2652 | 0.2652 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0349 | 0.086 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.1222 | 0.1222 |
Schistosoma mansoni | serine/threonine kinase | 0.0285 | 0.406 | 0.406 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.07 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0349 | 0.0349 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.0409 | 0.0409 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0349 | 0.4106 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0095 | 0.1222 | 0.1222 |
Echinococcus granulosus | calcium activated potassium channel | 0.0095 | 0.1222 | 0.1222 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0349 | 0.4106 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0349 | 0.4106 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0349 | 0.086 |
Trichomonas vaginalis | CAMK family protein kinase | 0.019 | 0.2652 | 0.6531 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.085 | 1 |
Brugia malayi | Kinase associated domain 1 family protein | 0.0094 | 0.1211 | 0.2984 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0095 | 0.1222 | 0.1222 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.085 | 1 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.019 | 0.2652 | 0.2652 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.1222 | 0.1222 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.07 | 0.07 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0349 | 0.4106 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0349 | 0.0349 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0349 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.1222 | 0.1222 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.085 | 0.2094 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0682 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0095 | 0.1222 | 0.1222 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.1222 | 0.1222 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0285 | 0.406 | 1 |
Giardia lamblia | Nuclear LIM interactor-interacting factor 1 | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.085 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.1222 | 0.1222 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0349 | 0.086 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.07 | 0.07 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0285 | 0.406 | 1 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0095 | 0.1222 | 0.1222 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0349 | 0.086 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0292 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.019 | 0.2652 | 0.6531 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.07 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.085 | 0.085 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.0409 | 0.0409 |
Brugia malayi | Protein kinase domain containing protein | 0.0285 | 0.406 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.085 | 0.2094 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0682 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1211 | 0.2984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.