Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.2384 | 0.2384 |
Entamoeba histolytica | pantothenate kinase 1, putative | 0.0084 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0084 | 1 | 1 |
Toxoplasma gondii | pantothenate kinase | 0.0035 | 0.2915 | 0.2915 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0084 | 1 | 1 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.2496 | 0.2496 |
Plasmodium falciparum | pantothenate kinase 1, putative | 0.0084 | 1 | 1 |
Schistosoma mansoni | rotamase | 0.0033 | 0.2496 | 0.2496 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.4819 | 0.3197 |
Plasmodium falciparum | pantothenate kinase 2, putative | 0.0035 | 0.2915 | 0.2915 |
Schistosoma mansoni | pantothenate kinase | 0.0084 | 1 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0032 | 0.2384 | 0.2384 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.2915 | 0.2915 |
Echinococcus granulosus | pantothenate kinase 4 | 0.0084 | 1 | 1 |
Giardia lamblia | Pantothenate kinase 4 | 0.0084 | 1 | 0.5 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0084 | 1 | 1 |
Schistosoma mansoni | pantothenate kinase | 0.0084 | 1 | 1 |
Echinococcus multilocularis | pantothenate kinase 4 | 0.0084 | 1 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0084 | 1 | 1 |
Onchocerca volvulus | Fumble homolog | 0.0084 | 1 | 0.5 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0033 | 0.2496 | 0.2496 |
Trypanosoma brucei | pantothenate kinase subunit, putative | 0.0084 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.2496 | 0.0147 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0084 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0032 | 0.2384 | 0.2384 |
Toxoplasma gondii | fumble protein | 0.0084 | 1 | 1 |
Plasmodium vivax | pantothenate kinase, putative | 0.0084 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0033 | 0.2496 | 0.2496 |
Loa Loa (eye worm) | pantothenate kinase | 0.0084 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.2384 | 0.2384 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0032 | 0.2384 | 0.2384 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0084 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0033 | 0.2496 | 0.2496 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.2496 | 0.0147 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0084 | 1 | 1 |
Leishmania major | pantothenate kinase subunit, putative | 0.0084 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.