Detailed information for compound 781537

Basic information

Technical information
  • TDR Targets ID: 781537
  • Name: 4-fluoro-N-[5-oxo-2-phenyl-1-propyl-4-(triflu oromethyl)imidazol-4-yl]benzamide
  • MW: 407.361 | Formula: C20H17F4N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1C(=NC(C1=O)(NC(=O)c1ccc(cc1)F)C(F)(F)F)c1ccccc1
  • InChi: 1S/C20H17F4N3O2/c1-2-12-27-16(13-6-4-3-5-7-13)25-19(18(27)29,20(22,23)24)26-17(28)14-8-10-15(21)11-9-14/h3-11H,2,12H2,1H3,(H,26,28)
  • InChiKey: MUKOGDYGGUIFBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-fluoro-N-[5-oxo-2-phenyl-1-propyl-4-(trifluoromethyl)-4-imidazolyl]benzamide
  • 4-fluoro-N-[5-keto-2-phenyl-1-propyl-4-(trifluoromethyl)imidazol-4-yl]benzamide
  • A4259/0181636

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0126 0.0773 0.0526
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0773 0.0526
Loa Loa (eye worm) hypothetical protein 0.019 0.1361 0.113
Loa Loa (eye worm) acetylcholinesterase 1 0.1123 1 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0773 0.0717
Schistosoma mansoni BC026374 protein (S09 family) 0.019 0.1361 0.1309
Onchocerca volvulus 0.0049 0.006 0.0441
Echinococcus granulosus acetylcholinesterase 0.1123 1 1
Schistosoma mansoni hypothetical protein 0.0168 0.1164 0.111
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.019 0.1361 0.113
Echinococcus multilocularis para nitrobenzyl esterase 0.019 0.1361 0.113
Echinococcus multilocularis BC026374 protein (S09 family) 0.019 0.1361 0.113
Echinococcus multilocularis acetylcholinesterase 0.1123 1 1
Loa Loa (eye worm) hypothetical protein 0.019 0.1361 0.113
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.019 0.1361 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0773 0.0717
Schistosoma mansoni neuroligin 3 (S09 family) 0.019 0.1361 0.1309
Brugia malayi Carboxylesterase family protein 0.019 0.1361 0.1309
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1743 1
Brugia malayi Carboxylesterase family protein 0.019 0.1361 0.1309
Loa Loa (eye worm) carboxylesterase 0.019 0.1361 0.113
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.019 0.1361 0.1309
Loa Loa (eye worm) hypothetical protein 0.019 0.1361 0.113
Echinococcus granulosus BC026374 protein S09 family 0.019 0.1361 0.113
Brugia malayi TAR-binding protein 0.0126 0.0773 0.0717
Loa Loa (eye worm) hypothetical protein 0.1123 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1123 1 1
Echinococcus multilocularis acetylcholinesterase 0.1123 1 1
Onchocerca volvulus 0.019 0.1361 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.026 0.1911
Loa Loa (eye worm) hypothetical protein 0.019 0.1361 0.113
Echinococcus multilocularis neuroligin 0.019 0.1361 0.113
Brugia malayi Carboxylesterase family protein 0.019 0.1361 0.1309
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0773 0.0526
Onchocerca volvulus 0.019 0.1361 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0773 0.0717
Loa Loa (eye worm) hypothetical protein 0.0241 0.1837 0.1619
Mycobacterium ulcerans carboxylesterase, LipT 0.019 0.1361 0.5
Echinococcus multilocularis geminin 0.0168 0.1164 0.0928
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0773 0.0717
Brugia malayi hypothetical protein 0.0241 0.1837 0.1788
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0773 0.0717
Echinococcus granulosus family S9 non peptidase ue S09 family 0.019 0.1361 0.113
Loa Loa (eye worm) carboxylesterase 0.019 0.1361 0.113
Echinococcus granulosus para nitrobenzyl esterase 0.019 0.1361 0.113
Schistosoma mansoni chromobox protein 0.0071 0.026 0.0201
Echinococcus granulosus geminin 0.0168 0.1164 0.0928
Echinococcus granulosus neuroligin 0.019 0.1361 0.113
Brugia malayi Carboxylesterase family protein 0.1123 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0773 0.0717
Echinococcus granulosus acetylcholinesterase 0.1123 1 1
Schistosoma mansoni hypothetical protein 0.0168 0.1164 0.111
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1837 0.1619
Loa Loa (eye worm) RNA binding protein 0.0126 0.0773 0.0526
Schistosoma mansoni gliotactin 0.019 0.1361 0.1309
Schistosoma mansoni chromobox protein 0.0071 0.026 0.0201
Loa Loa (eye worm) carboxylesterase 0.1123 1 1
Loa Loa (eye worm) hypothetical protein 0.019 0.1361 0.113
Loa Loa (eye worm) hypothetical protein 0.019 0.1361 0.113
Trichomonas vaginalis chromobox protein, putative 0.0071 0.026 0.1911
Onchocerca volvulus 0.019 0.1361 1
Brugia malayi RNA binding protein 0.0126 0.0773 0.0717
Trichomonas vaginalis spcc417.12 protein, putative 0.019 0.1361 1
Schistosoma mansoni acetylcholinesterase 0.019 0.1361 0.1309
Brugia malayi Heterochromatin protein 1 0.0071 0.026 0.0201
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.019 0.1361 0.1309
Loa Loa (eye worm) hypothetical protein 0.1123 1 1
Brugia malayi hypothetical protein 0.019 0.1361 0.1309
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1837 0.1619
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.019 0.1361 0.1309
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0773 0.0526
Brugia malayi Carboxylesterase family protein 0.019 0.1361 0.1309
Loa Loa (eye worm) hypothetical protein 0.019 0.1361 0.113
Echinococcus granulosus carboxylesterase 5A 0.1123 1 1
Onchocerca volvulus 0.019 0.1361 1
Onchocerca volvulus 0.019 0.1361 1
Echinococcus multilocularis carboxylesterase 5A 0.1123 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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