Detailed information for compound 781922

Basic information

Technical information
  • TDR Targets ID: 781922
  • Name: N-(3-methoxypropyl)-4-methyl-3-(2-oxopyrrolid in-1-yl)benzamide
  • MW: 290.357 | Formula: C16H22N2O3
  • H donors: 1 H acceptors: 2 LogP: 1.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)c1ccc(c(c1)N1CCCC1=O)C
  • InChi: 1S/C16H22N2O3/c1-12-6-7-13(16(20)17-8-4-10-21-2)11-14(12)18-9-3-5-15(18)19/h6-7,11H,3-5,8-10H2,1-2H3,(H,17,20)
  • InChiKey: KMGLZHPIEVMJKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-methoxypropyl)-4-methyl-3-(2-oxo-1-pyrrolidinyl)benzamide
  • 3-(2-ketopyrrolidin-1-yl)-N-(3-methoxypropyl)-4-methyl-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.01 0.1152 0.1152
Loa Loa (eye worm) hypothetical protein 0.0147 0.2112 0.2112
Loa Loa (eye worm) hypothetical protein 0.0529 1 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0089 0.0923 0.0923
Echinococcus granulosus BC026374 protein S09 family 0.0089 0.0923 0.0923
Schistosoma mansoni hypothetical protein 0.0046 0.0037 0.0037
Brugia malayi Carboxylesterase family protein 0.0089 0.0923 0.0923
Echinococcus multilocularis GPCR, family 2 0.0046 0.0037 0.0037
Schistosoma mansoni BC026374 protein (S09 family) 0.0089 0.0923 0.0923
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.2112 0.2112
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0089 0.0923 0.0923
Echinococcus granulosus GPCR family 2 0.0046 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.0923
Loa Loa (eye worm) acetylcholinesterase 1 0.0529 1 1
Trichomonas vaginalis set domain proteins, putative 0.023 0.3827 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0089 0.0923 0.5
Loa Loa (eye worm) carboxylesterase 0.0089 0.0923 0.0923
Echinococcus multilocularis acetylcholinesterase 0.0529 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.2112 0.2112
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0037 0.0037
Loa Loa (eye worm) carboxylesterase 0.0529 1 1
Brugia malayi hypothetical protein 0.0089 0.0923 0.0923
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0089 0.0923 0.0923
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0089 0.0923 0.0923
Schistosoma mansoni hypothetical protein 0.0046 0.0037 0.0037
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0089 0.0923 0.5
Echinococcus granulosus para nitrobenzyl esterase 0.0089 0.0923 0.0923
Echinococcus granulosus geminin 0.033 0.5892 0.5892
Brugia malayi Pre-SET motif family protein 0.0202 0.325 0.325
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.2112 0.2112
Echinococcus multilocularis carboxylesterase 5A 0.0529 1 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0089 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0529 1 1
Schistosoma mansoni gliotactin 0.0089 0.0923 0.0923
Loa Loa (eye worm) carboxylesterase 0.0089 0.0923 0.0923
Brugia malayi Carboxylesterase family protein 0.0529 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0037 0.0037
Brugia malayi Carboxylesterase family protein 0.0089 0.0923 0.0923
Schistosoma mansoni hypothetical protein 0.0046 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.0923
Schistosoma mansoni hypothetical protein 0.0046 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.0923
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0037 0.0037
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0089 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0046 0.0037 0.0037
Echinococcus granulosus acetylcholinesterase 0.0529 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.1152 0.1152
Onchocerca volvulus 0.023 0.3827 1
Schistosoma mansoni acetylcholinesterase 0.0089 0.0923 0.0923
Echinococcus multilocularis acetylcholinesterase 0.0529 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.325 0.325
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0037 0.0037
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0089 0.0923 0.0923
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0089 0.0923 0.5
Schistosoma mansoni memapsin-2 (A01 family) 0.0447 0.8315 0.8315
Echinococcus multilocularis neuroligin 0.0089 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.0923
Echinococcus granulosus neuroligin 0.0089 0.0923 0.0923
Brugia malayi Carboxylesterase family protein 0.0089 0.0923 0.0923
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0037 0.0037
Brugia malayi Carboxylesterase family protein 0.0089 0.0923 0.0923
Echinococcus granulosus carboxylesterase 5A 0.0529 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.0923
Echinococcus granulosus acetylcholinesterase 0.0529 1 1
Schistosoma mansoni hypothetical protein 0.033 0.5892 0.5892
Mycobacterium tuberculosis Carboxylesterase LipT 0.0089 0.0923 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0037 0.0037
Echinococcus multilocularis BC026374 protein (S09 family) 0.0089 0.0923 0.0923
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0529 1 1
Echinococcus multilocularis geminin 0.033 0.5892 0.5892
Schistosoma mansoni hypothetical protein 0.01 0.1152 0.1152
Schistosoma mansoni hypothetical protein 0.033 0.5892 0.5892

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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