Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.2589 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1693 | 0.1693 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1693 | 0.6539 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.2589 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0439 | 0.1695 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.2589 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.2589 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1693 | 0.6539 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.2589 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.2241 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.2589 | 0.2589 |
Echinococcus granulosus | lamin | 0.0033 | 0.1693 | 0.6539 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2503 | 0.9667 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.2589 | 1 |
Onchocerca volvulus | 0.0033 | 0.1693 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.6692 | 0.6692 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2503 | 0.9667 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.2241 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2503 | 0.9667 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.2589 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.2589 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.2589 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.6692 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0439 | 0.1695 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1693 | 0.6539 |
Schistosoma mansoni | lamin | 0.0033 | 0.1693 | 0.6539 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0567 | 0.0567 |
Brugia malayi | Inositol-1 | 0.0045 | 0.2589 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0439 | 0.0439 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1693 | 0.6539 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.2589 | 0.0206 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1693 | 0.6539 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1649 | 0.1649 |
Onchocerca volvulus | 0.0033 | 0.1693 | 0.5 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.2589 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1693 | 0.1693 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2503 | 0.9667 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.2589 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0394 | 0.0394 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0567 | 0.0567 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.2589 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.1693 | 0.6539 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.2589 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2503 | 0.2503 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1693 | 0.1693 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.2589 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1693 | 0.6539 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.6692 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.