Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.4859 | 0.4859 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0058 | 0.9797 | 0.975 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0025 | 0.3092 | 0.1502 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1871 | 0.1871 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1871 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0025 | 0.3092 | 0.1502 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1871 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1871 | 0.1871 |
Giardia lamblia | Hypothetical protein | 0.0035 | 0.5062 | 1 |
Giardia lamblia | Hypothetical protein | 0.0035 | 0.5062 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1871 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.1871 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1871 | 0.1871 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1871 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0058 | 0.9797 | 0.975 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1871 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0059 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1871 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1871 | 0.1871 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1871 | 0.1871 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1871 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0025 | 0.3092 | 0.1502 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0035 | 0.5062 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.5062 | 1 |
Onchocerca volvulus | 0.0059 | 1 | 1 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0058 | 0.9797 | 0.975 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0059 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0058 | 0.9797 | 0.975 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0035 | 0.5062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.9797 | 0.9797 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0025 | 0.3092 | 0.1502 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1871 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.