Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.5062 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1871 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0035 | 0.5062 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1871 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0025 | 0.3092 | 0.1502 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0025 | 0.3092 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.9797 | 0.9797 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1871 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1871 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.1871 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0058 | 0.9797 | 0.975 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.4859 | 0.4859 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0025 | 0.3092 | 0.1502 |
Onchocerca volvulus | 0.0059 | 1 | 1 | |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1871 | 0.1871 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1871 | 0.1871 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0035 | 0.5062 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0035 | 0.5062 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0058 | 0.9797 | 0.975 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1871 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0059 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0025 | 0.3092 | 0.1502 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1871 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0058 | 0.9797 | 0.975 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0058 | 0.9797 | 0.975 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0059 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0035 | 0.5062 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1871 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1871 | 0.1871 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1871 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.