Detailed information for compound 784557

Basic information

Technical information
  • TDR Targets ID: 784557
  • Name: 2-[(2-bromo-4-chlorophenyl)amino]-N-[(3-nitro phenyl)methylideneamino]acetamide
  • MW: 411.638 | Formula: C15H12BrClN4O3
  • H donors: 2 H acceptors: 3 LogP: 4.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNc1ccc(cc1Br)Cl)N/N=C/c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C15H12BrClN4O3/c16-13-7-11(17)4-5-14(13)18-9-15(22)20-19-8-10-2-1-3-12(6-10)21(23)24/h1-8,18H,9H2,(H,20,22)/b19-8+
  • InChiKey: ACDSAAOVPUNSPB-UFWORHAWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-bromo-4-chloro-phenyl)amino]-N-[(3-nitrophenyl)methyleneamino]acetamide
  • 2-[(2-bromo-4-chlorophenyl)amino]-N-[(3-nitrophenyl)methyleneamino]acetamide
  • 2-[(2-bromo-4-chloro-phenyl)amino]-N-[(3-nitrobenzylidene)amino]acetamide
  • 2-[(2-bromo-4-chloro-phenyl)amino]-N-[(3-nitrophenyl)methylideneamino]ethanamide
  • A0662/0030809

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.2804 0.2079
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.2804 0.2079
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.000000002293
Loa Loa (eye worm) hypothetical protein 0.0026 0.4788 0.4732
Entamoeba histolytica recQ family helicase, putative 0.0019 0.2804 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 1 1
Onchocerca volvulus 0.0026 0.4788 0.5
Schistosoma mansoni intermediate filament proteins 0.0026 0.4788 0.4788
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.2804 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0778 0.0679
Loa Loa (eye worm) hypothetical protein 0.0013 0.0915 0.0817
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.2804 0.5
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0107 0.5
Echinococcus multilocularis lamin dm0 0.0026 0.4788 0.4263
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.1313 0.1219
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.2804 0.5
Echinococcus granulosus lamin dm0 0.0026 0.4788 0.4263
Brugia malayi intermediate filament protein 0.0026 0.4788 0.4001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.2804 0.2079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0107 0.0381
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.4788 0.4001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2804 1
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.2804 0.1717
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.2804 0.2079
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0107 1
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.2804 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2804 1
Onchocerca volvulus 0.0026 0.4788 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0026 0.4652 0.4594
Echinococcus granulosus lamin 0.0026 0.4788 0.4263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.2804 0.2726
Schistosoma mansoni DNA helicase recq1 0.0019 0.2804 0.2804
Echinococcus granulosus intermediate filament protein 0.0026 0.4788 0.4263
Loa Loa (eye worm) hypothetical protein 0.0012 0.0778 0.0679
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 1 1
Echinococcus multilocularis musashi 0.0026 0.4788 0.4263
Echinococcus multilocularis lamin 0.0026 0.4788 0.4263
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.2804 0.5
Schistosoma mansoni lamin 0.0026 0.4788 0.4788
Echinococcus granulosus bloom syndrome protein 0.0019 0.2804 0.2079
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.2804 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.2804 1
Schistosoma mansoni DNA helicase recq5 0.0019 0.2804 0.2804
Echinococcus multilocularis bloom syndrome protein 0.0019 0.2804 0.2079
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.2804 0.5
Schistosoma mansoni lamin 0.0026 0.4788 0.4788
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.4788 0.4732
Loa Loa (eye worm) hypothetical protein 0.0019 0.2804 0.2726
Loa Loa (eye worm) RecQ helicase 0.0019 0.2804 0.2726
Loa Loa (eye worm) intermediate filament protein 0.0026 0.4788 0.4732
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2804 0.1717
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2804 0.1717
Entamoeba histolytica recQ family DNA helicase 0.001 0.0107 0.0381
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.2804 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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