Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.4296 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4296 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0.4296 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.7191 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.4296 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4296 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.4296 | 0.5 |
Echinococcus granulosus | nephrin | 0.0073 | 0.7191 | 1 |
Echinococcus granulosus | nephrin | 0.0073 | 0.7191 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.4296 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0093 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.4296 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0093 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4296 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0.4296 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.4296 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0093 | 1 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0073 | 0.7191 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.4296 | 0.4296 |
Echinococcus granulosus | Immunoglobulin | 0.0073 | 0.7191 | 1 |
Echinococcus granulosus | irregular chiasm roughest protein | 0.0073 | 0.7191 | 1 |
Brugia malayi | hypothetical protein | 0.0093 | 1 | 1 |
Echinococcus multilocularis | nephrin | 0.0073 | 0.7191 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4296 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0.4296 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0073 | 0.7191 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.4296 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.7191 | 1 |
Echinococcus multilocularis | irregular chiasm roughest protein immunoglobulin set domain containing protein | 0.0073 | 0.7191 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Normalization (functional) | = 44 % | In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice by normalization of blood glucose levels at a dose of 10 mg/kg. | ChEMBL. | 1588563 |
Normalization (functional) | = 44 % | In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice by normalization of blood glucose levels at a dose of 10 mg/kg. | ChEMBL. | 1588563 |
Normalization (functional) | = 65 % | In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice measured by normalization of blood glucose levels at a dose of 5 mg/kg. | ChEMBL. | 1588563 |
Normalization (functional) | = 65 % | In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice measured by normalization of blood glucose levels at a dose of 5 mg/kg. | ChEMBL. | 1588563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.