Detailed information for compound 794362

Basic information

Technical information
  • TDR Targets ID: 794362
  • Name: 1-(1-adamantyl)-4-(4-propoxyphenyl)sulfonylpi perazine
  • MW: 418.593 | Formula: C23H34N2O3S
  • H donors: 0 H acceptors: 2 LogP: 4.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C23H34N2O3S/c1-2-11-28-21-3-5-22(6-4-21)29(26,27)25-9-7-24(8-10-25)23-15-18-12-19(16-23)14-20(13-18)17-23/h3-6,18-20H,2,7-17H2,1H3
  • InChiKey: ORJFYUPREGGLMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(1-adamantyl)-4-(4-propoxyphenyl)sulfonyl-piperazine
  • A2938/0123702

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0063
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0292 0.0292
Plasmodium falciparum phd finger protein, putative 0.0028 0.0166 1
Echinococcus multilocularis RUN 0.0019 0.0063 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0032 0.0206 0.0144
Onchocerca volvulus Alhambra homolog 0.0028 0.0166 0.0104
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0283 0.0267
Schistosoma mansoni hypothetical protein 0.0178 0.185 0.1798
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0206 0.0206
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0283 0.0283
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0166 0.0166
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0283 0.5
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.7666 0.7652
Echinococcus granulosus intermediate filament protein 0.0028 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0032 0.0206 0.0144
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0166
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0063 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0234 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0983 0.0968
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0063 0.0063
Echinococcus multilocularis geminin 0.0178 0.185 0.185
Echinococcus granulosus geminin 0.0178 0.185 0.185
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0028 0.0165 0.0165
Brugia malayi PHD-finger family protein 0.0028 0.0166 0.015
Schistosoma mansoni lipoxygenase 0.0115 0.1142 0.1086
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0283 0.5
Brugia malayi intermediate filament protein 0.0028 0.0165 0.0148
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0063 0.0063
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0063 0.0063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0537 0.5892 0.5892
Echinococcus multilocularis lamin dm0 0.0028 0.0165 0.0165
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0895 0.0895
Schistosoma mansoni lipoxygenase 0.008 0.0752 0.0694
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0166 0.0166
Echinococcus granulosus tm gpcr rhodopsin 0.0537 0.5892 0.5892
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0234 0.0172
Brugia malayi hypothetical protein 0.0019 0.0063 0.0046
Echinococcus granulosus microtubule associated protein 2 0.0694 0.7666 0.7666
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0283 0.0222
Echinococcus granulosus lamin 0.0028 0.0165 0.0165
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0895 0.0895
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0283 0.0222
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0166 0.0166
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0283 0.0283
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0283 0.0283
Brugia malayi Doublecortin family protein 0.0019 0.0063 0.0046
Loa Loa (eye worm) hypothetical protein 0.0049 0.0395 0.0395
Schistosoma mansoni hypothetical protein 0.0032 0.0206 0.0144
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0283 0.0283
Echinococcus multilocularis peregrin 0.0028 0.0166 0.0166
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0166 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0283
Mycobacterium ulcerans short chain dehydrogenase 0.0225 0.2381 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0166 0.5
Schistosoma mansoni lamin 0.0028 0.0165 0.0103
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0508 0.0508
Echinococcus granulosus lamin dm0 0.0028 0.0165 0.0165
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0032 0.0206 0.0206
Brugia malayi jmjC domain containing protein 0.0034 0.0234 0.0217
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0063 0.0063
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0283 0.5
Onchocerca volvulus 0.0028 0.0165 0.0103
Brugia malayi jmjC domain containing protein 0.0093 0.0895 0.088
Onchocerca volvulus 0.0028 0.0165 0.0103
Echinococcus granulosus peregrin 0.0028 0.0166 0.0166
Echinococcus multilocularis vesicular acetylcholine transporter 0.0902 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.1142 0.1142
Echinococcus granulosus GPCR family 2 0.0032 0.0206 0.0206
Schistosoma mansoni intermediate filament proteins 0.0028 0.0165 0.0103
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0902 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0063 0.0063
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0165 0.0148
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0069 0.0624 0.0624
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0032 0.0206 0.0144
Brugia malayi hypothetical protein 0.0019 0.0063 0.0046
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0283 0.5
Brugia malayi N-terminal motif family protein 0.0182 0.1892 0.1878
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0166 0.0104
Echinococcus multilocularis lamin 0.0028 0.0165 0.0165
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.7666 0.7666
Schistosoma mansoni jumonji domain containing protein 0.0074 0.068 0.0621
Echinococcus granulosus jumonji domain containing protein 0.004 0.0292 0.0292
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0206 0.0206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0206 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0063
Echinococcus multilocularis GPCR, family 2 0.0032 0.0206 0.0206
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0165 0.0165
Echinococcus granulosus vesicular acetylcholine transporter 0.0902 1 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0206 0.0189
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0069 0.0624 0.0564
Schistosoma mansoni hypothetical protein 0.0178 0.185 0.1798
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0283 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0283 0.5
Schistosoma mansoni lamin 0.0028 0.0165 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0225 0.2381 0.5
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0902 1 1
Schistosoma mansoni vesicular acetylcholine transporter 0.0902 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0206 0.0206
Brugia malayi Bromodomain containing protein 0.0028 0.0166 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0101 0.0983 0.0983
Schistosoma mansoni hypothetical protein 0.0028 0.0166 0.0104
Echinococcus multilocularis musashi 0.0028 0.0165 0.0165
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0206 0.0206
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0206 0.0206
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0166 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0983 0.0983
Echinococcus granulosus RUN 0.0019 0.0063 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0624 0.0608
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0283 0.0283
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0283 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0983 0.0968
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0283 0.5
Loa Loa (eye worm) hypothetical protein 0.0182 0.1892 0.1892
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0159
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.1892 0.1841
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0283 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.