Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 0.4921 | 0.4921 |
Onchocerca volvulus | 0.0244 | 0.2701 | 0.7736 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1209 | 0.1209 |
Onchocerca volvulus | Huntingtin homolog | 0.0126 | 0.1209 | 0.3462 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0821 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1209 | 0.1209 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0821 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.2701 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0821 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0821 | 1 | 1 |
Onchocerca volvulus | 0.0307 | 0.3492 | 1 | |
Onchocerca volvulus | Huntingtin homolog | 0.0126 | 0.1209 | 0.3462 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0215 | 0.2326 | 0.2326 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1209 | 0.1209 |
Brugia malayi | Pre-SET motif family protein | 0.0215 | 0.2326 | 0.2326 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 36 % | Inhibitory concentration of the compound against rat brain mitochondrial Monoamine oxidase A at 10 microM | ChEMBL. | 8627609 |
Inhibition (binding) | = 36 % | Inhibitory concentration of the compound against rat brain mitochondrial Monoamine oxidase A at 10 microM | ChEMBL. | 8627609 |
Inhibition (binding) | = 49 % | Inhibitory activity of the compound against rat brain mitochondrial Monoamine oxidase B at 10 microM | ChEMBL. | 8627609 |
Inhibition (binding) | = 49 % | Inhibitory activity of the compound against rat brain mitochondrial Monoamine oxidase B at 10 microM | ChEMBL. | 8627609 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.