Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 4C, cAMP-specific | References | |
Homo sapiens | phosphodiesterase 4A, cAMP-specific | References | |
Homo sapiens | phosphodiesterase 4B, cAMP-specific | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0392 | 0.6577 | 0.8553 |
Entamoeba histolytica | cytidine deaminase, putative | 0.0559 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein, putative | 0.0559 | 1 | 0.5 |
Mycobacterium ulcerans | cytidine deaminase | 0.0559 | 1 | 0.5 |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.0559 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0392 | 0.6577 | 0.6577 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0447 | 0.7689 | 0.7689 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0447 | 0.7689 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0447 | 0.7689 | 0.7689 |
Giardia lamblia | Cytidine deaminase | 0.0559 | 1 | 1 |
Trypanosoma cruzi | cytidine deaminase-like protein | 0.0559 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.0559 | 1 | 0.5 |
Echinococcus granulosus | cytidine deaminase | 0.0559 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0447 | 0.7689 | 0.7689 |
Onchocerca volvulus | 0.0559 | 1 | 0.5 | |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.0559 | 1 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0392 | 0.6577 | 0.6577 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0392 | 0.6577 | 0.6577 |
Echinococcus multilocularis | cytidine deaminase | 0.0559 | 1 | 1 |
Leishmania major | cytidine deaminase-like protein | 0.0559 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0559 | 1 | 0.5 |
Onchocerca volvulus | 0.0559 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.7689 | 1 |
Trypanosoma brucei | cytidine deaminase | 0.0559 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0559 | 1 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0447 | 0.7689 | 0.7689 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 nM | Inhibition of tumor necrosis factor-alpha release from activated human monocyte cells (No data) | ChEMBL. | 9873449 |
IC50 (functional) | 0 nM | Inhibition of tumor necrosis factor-alpha release from activated human monocyte cells in the presence of RP73401 (No data) | ChEMBL. | 9873449 |
IC50 (binding) | = 80 nM | Inhibitory activity against Phosphodiesterase type IV (PDE4) obtained from guinea-pig macrophage was evaluated | ChEMBL. | 9873449 |
IC50 (binding) | = 80 nM | Inhibitory activity against Phosphodiesterase type IV (PDE4) obtained from guinea-pig macrophage was evaluated | ChEMBL. | 9873449 |
Inhibition (functional) | % | Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in mice at 50 mg/kg (No data) | ChEMBL. | 9873449 |
Inhibition (functional) | 0 % | Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in mice at 50 mg/kg (No data) | ChEMBL. | 9873449 |
Ki (binding) | = 54 nM | Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assay | ChEMBL. | 9873449 |
Ki (binding) | = 54 nM | Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assay | ChEMBL. | 9873449 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.