Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) | 0.0044 | 0.0592 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0003 | 0.0011 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0097 | 1 |
Brugia malayi | hypothetical protein | 0.0151 | 0.2814 | 0.2814 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.1005 | 0.3144 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.002 | 0.0097 | 0.1637 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.2154 | 0.7656 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0672 | 0.2103 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0672 | 0.0672 |
Echinococcus granulosus | nibrin | 0.002 | 0.0097 | 0.0303 |
Mycobacterium tuberculosis | Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) | 0.0044 | 0.0592 | 0.0592 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0495 | 1 | 1 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0044 | 0.0592 | 0.1852 |
Mycobacterium ulcerans | ornithine aminotransferase RocD1 and RocD2 | 0.0044 | 0.0592 | 0.05 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0672 | 0.2103 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.2154 | 0.2154 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.002 | 0.0097 | 0.0097 |
Brugia malayi | RNA binding protein | 0.0064 | 0.1005 | 0.1005 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0003 | 0.0011 |
Brugia malayi | topoisomerase | 0.002 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0721 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0344 |
Echinococcus granulosus | geminin | 0.0169 | 0.3196 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0469 | 0.288 |
Schistosoma mansoni | topbp1 | 0.002 | 0.0097 | 0.0303 |
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | 0.0044 | 0.0592 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0097 | 0.0097 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.002 | 0.0097 | 0.0303 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0003 | 0.0011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1005 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2814 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.2154 | 0.7656 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0003 | 0.0011 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.002 | 0.0097 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0344 |
Plasmodium falciparum | ornithine aminotransferase | 0.0044 | 0.0592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0003 | 0.0012 |
Echinococcus granulosus | replication factor c subunit 1 | 0.002 | 0.0097 | 0.0303 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0672 | 0.2103 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0344 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.1005 | 0.1005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1005 | 0.3144 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0044 | 0.0592 | 0.1852 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1005 | 0.3144 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.1005 | 0.357 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.002 | 0.0097 | 0.0097 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0469 | 0.288 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0044 | 0.0592 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0389 | 0.1216 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0721 | 0.2561 |
Mycobacterium tuberculosis | Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) | 0.0044 | 0.0592 | 0.0592 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0003 | 0.0012 |
Schistosoma mansoni | topbp1 | 0.002 | 0.0097 | 0.0303 |
Echinococcus multilocularis | nibrin | 0.002 | 0.0097 | 0.0303 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0044 | 0.0592 | 1 |
Echinococcus multilocularis | Aminotransferase class III | 0.0044 | 0.0592 | 0.1852 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0003 | 0.0011 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0082 | 0.1389 | 1 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0044 | 0.0592 | 0.0592 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0672 | 0.2388 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0044 | 0.0592 | 0.1852 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0003 | 0.0011 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0469 | 0.1468 |
Treponema pallidum | DNA ligase (lig) | 0.002 | 0.0097 | 0.5 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0.0097 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1005 | 0.3144 |
Onchocerca volvulus | 0.0151 | 0.2814 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0344 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0592 | 0.05 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0672 | 0.2103 |
Mycobacterium ulcerans | 4-aminobutyrate aminotransferase | 0.0044 | 0.0592 | 0.05 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0003 | 0.0011 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0495 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0097 | 1 |
Brugia malayi | DKFZp564C0469 protein | 0.002 | 0.0097 | 0.0097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1005 | 0.3144 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0469 | 0.0469 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0.0097 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.3196 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0044 | 0.0592 | 1 |
Schistosoma mansoni | DNA ligase IV | 0.002 | 0.0097 | 0.0303 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0044 | 0.0592 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0469 | 0.1468 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3196 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0003 | 0.0011 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0721 | 0.0721 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0082 | 0.1389 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.1005 | 0.357 |
Toxoplasma gondii | ATPase, AAA family protein | 0.002 | 0.0097 | 0.1637 |
Mycobacterium ulcerans | 4-aminobutyrate aminotransferase | 0.0044 | 0.0592 | 0.05 |
Brugia malayi | hypothetical protein | 0.002 | 0.0097 | 0.0097 |
Echinococcus granulosus | ornithine aminotransferase | 0.0044 | 0.0592 | 0.1852 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0672 | 0.2103 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.002 | 0.0097 | 0.0303 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0044 | 0.0592 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetylornithine aminotransferase ArgD | 0.0044 | 0.0592 | 0.0592 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.1005 | 0.1005 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.1005 | 0.3144 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.1005 | 0.357 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3196 | 1 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0044 | 0.0592 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0469 | 0.288 |
Echinococcus granulosus | Aminotransferase class III | 0.0044 | 0.0592 | 0.1852 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0389 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0003 | 0.0011 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0044 | 0.0592 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1389 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0344 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0469 | 0.288 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0469 | 0.1468 |
Mycobacterium ulcerans | glutamate-1-semialdehyde aminotransferase | 0.0044 | 0.0592 | 0.05 |
Mycobacterium ulcerans | acetylornithine aminotransferase | 0.0044 | 0.0592 | 0.05 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.002 | 0.0097 | 0.1637 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0003 | 0.0011 |
Mycobacterium leprae | Probable Acetylornithine aminotransferase ArgD | 0.0044 | 0.0592 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0672 | 0.2103 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0389 | 0.1381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0672 | 0.2103 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0003 | 0.0003 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0721 | 0.0721 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.002 | 0.0097 | 0.1637 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0469 | 0.1468 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0044 | 0.0592 | 0.0592 |
Giardia lamblia | Replication factor C, subunit 1 | 0.002 | 0.0097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0344 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.