Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0415 | 0.3277 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0995 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0972 | 0.4619 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0995 | 0.4727 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0972 | 0.9744 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0972 | 0.9744 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 1 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0415 | 0.3277 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0995 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.2079 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.3738 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.3738 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0132 | 0.0531 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 1 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0109 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 1 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0109 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 1 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0195 | 0.0735 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0109 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0972 | 0.4619 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0109 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 1 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.0995 | 1 | |
Onchocerca volvulus | 0.0031 | 0.0995 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0995 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.3738 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0995 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0195 | 0.0735 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0913 | 0.4331 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0995 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0995 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0474 | 0.3489 |
Echinococcus granulosus | lamin | 0.0031 | 0.0995 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0995 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0913 | 0.8987 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 1 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0913 | 0.8982 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0109 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0995 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0394 | 0.2488 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0394 | 0.2488 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0109 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.3738 | 0.5 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0995 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0109 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0474 | 0.3522 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0109 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.3738 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0109 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0974 | 0.9743 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.3738 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0995 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.3738 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0995 | 0.4727 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0109 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0415 | 0.2744 |
Schistosoma mansoni | lamin | 0.0031 | 0.0995 | 0.4727 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.11 uM | Inhibition of the isolated native E. coli peptide deformylase (PDF) | ChEMBL. | 11384231 |
IC50 (binding) | = 0.11 uM | Inhibition of the isolated native E. coli peptide deformylase (PDF) | ChEMBL. | 11384231 |
MIC (functional) | = 4 ug ml-1 | In vitro antibacterial activity against Moraxella catarrhalis RA21 | ChEMBL. | 11384231 |
MIC (functional) | > 64 ug ml-1 | In vitro antibacterial activity against Escherichia coli | ChEMBL. | 11384231 |
MIC (functional) | = 64 ug ml-1 | In vitro antibacterial activity against Haemophilus influenzae 11 | ChEMBL. | 11384231 |
MIC (functional) | > 64 ug ml-1 | In vitro antibacterial activity against Escherichia coli | ChEMBL. | 11384231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.