Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0686 | 0.0686 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0226 | 0.8362 | 0.8362 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0127 | 0.0127 |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.8362 | 0.8362 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0262 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0226 | 0.8362 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0 | 0.5 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0127 | 0.0127 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0127 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.0127 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0127 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.8362 | 0.8362 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0127 | 0.0127 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0127 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8362 | 0.8362 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.8362 | 0.8362 |
Loa Loa (eye worm) | carboxylesterase | 0.0226 | 0.8362 | 0.8362 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0127 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0127 | 0.0152 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0127 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.0127 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8362 | 0.8362 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0226 | 0.8362 | 0.8362 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0686 | 0.0821 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.8362 | 0.8362 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0127 | 0.0152 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0127 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.8362 | 0.8362 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0127 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.8362 | 0.8362 |
Echinococcus granulosus | carboxylesterase 5A | 0.0226 | 0.8362 | 0.8362 |
Onchocerca volvulus | 0.0054 | 0.0686 | 1 | |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0127 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0686 | 0.0821 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0127 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0127 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.