Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.0341 | 0.3185 | 0.4418 |
Echinococcus multilocularis | geminin | 0.0168 | 0.0836 | 0.1159 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0842 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0842 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0836 | 1 |
Echinococcus multilocularis | solute carrier family 28 | 0.0341 | 0.3185 | 0.4418 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.032 | 0.2902 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0107 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0836 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0107 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.0637 | 0.721 | 0.6902 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.0637 | 0.721 | 0.6902 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.032 | 0.2902 | 0.5 |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.0222 | 0.1573 | 0.2182 |
Echinococcus granulosus | thymidine phosphorylase | 0.0637 | 0.721 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0107 | 0 | 0.5 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.0341 | 0.3185 | 0.4418 |
Echinococcus granulosus | tumor protein p63 | 0.0333 | 0.3079 | 0.427 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0842 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0107 | 0 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0333 | 0.3079 | 0.427 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0107 | 0 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0107 | 0 | 0.5 |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.0341 | 0.3185 | 0.4418 |
Echinococcus granulosus | geminin | 0.0168 | 0.0836 | 0.1159 |
Echinococcus granulosus | solute carrier family 28 | 0.0341 | 0.3185 | 0.4418 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0107 | 0 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.0637 | 0.721 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0107 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | In vivo inhibition of 10 nmole/kg PAF-induced hemoconcentration was determined at 1 mg/kg peroral administration | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | In vivo inhibition of 10 nmole/kg PAF-induced hemoconcentration was determined at 1 mg/kg peroral administration | ChEMBL. | No reference |
Inhibition (binding) | = 5 % | In vivo inhibition of 10 nmole/kg PAF-induced plasma N-acetyl-beta-glucosaminidase (NAGA) after oral administration to rats | ChEMBL. | No reference |
Inhibition (binding) | = 5 % | In vivo inhibition of 10 nmole/kg PAF-induced plasma N-acetyl-beta-glucosaminidase (NAGA) after oral administration to rats | ChEMBL. | No reference |
Inhibition (binding) | = 45 % | In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor. | ChEMBL. | No reference |
Inhibition (binding) | = 45 % | In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.