Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hexokinase | 0.0086 | 0.3799 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0116 | 0.5747 | 0.8342 |
Echinococcus granulosus | hexokinase | 0.0086 | 0.3799 | 0.3599 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.1563 | 0.4055 |
Brugia malayi | jmjC domain containing protein | 0.0103 | 0.4892 | 0.7477 |
Onchocerca volvulus | 0.0086 | 0.3799 | 1 | |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.1563 | 0.4055 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.1563 | 0.239 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0311 | 0.0725 |
Brugia malayi | Hexokinase family protein | 0.0054 | 0.1749 | 0.2673 |
Trypanosoma brucei | hexokinase | 0.0086 | 0.3799 | 1 |
Echinococcus granulosus | hexokinase | 0.0086 | 0.3799 | 0.3599 |
Trypanosoma cruzi | hexokinase, putative | 0.0086 | 0.3799 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0086 | 0.3799 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0086 | 0.3799 | 0.3599 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0783 | 0.1196 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.1563 | 0.239 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0086 | 0.3799 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0735 | 0.1123 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0129 | 0.6578 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.1563 | 0.4055 |
Leishmania major | trypanothione reductase | 0.0051 | 0.1563 | 0.4055 |
Brugia malayi | hexokinase type II | 0.0027 | 0.0047 | 0.0072 |
Trypanosoma cruzi | hexokinase, putative | 0.0086 | 0.3799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.175 | 0.2674 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.1563 | 0.1292 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0116 | 0.5747 | 0.8342 |
Onchocerca volvulus | 0.0086 | 0.3799 | 1 | |
Brugia malayi | hypothetical protein | 0.0027 | 0.0039 | 0.0059 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0116 | 0.5747 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0039 | 0.0059 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.1563 | 0.4055 |
Echinococcus multilocularis | hexokinase type 2 | 0.0086 | 0.3799 | 0.3599 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0783 | 0.0486 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.1563 | 0.4055 |
Loa Loa (eye worm) | hexokinase type II | 0.0086 | 0.3799 | 0.5806 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.0735 | 0.0437 |
Mycobacterium tuberculosis | Probable reductase | 0.0116 | 0.5747 | 0.8342 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.0311 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0311 | 0.0476 |
Echinococcus multilocularis | hexokinase | 0.0086 | 0.3799 | 0.3599 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0735 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0047 | 0.0072 |
Onchocerca volvulus | Hexokinase homolog | 0.0054 | 0.1749 | 0.4122 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0783 | 0.0486 |
Brugia malayi | hexokinase | 0.0086 | 0.3799 | 0.5806 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0783 | 0.0486 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.1563 | 0.4055 |
Plasmodium vivax | hexokinase, putative | 0.0086 | 0.3799 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.0311 | 0.0476 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.6543 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0086 | 0.3799 | 1 |
Leishmania major | hexokinase, putative | 0.0086 | 0.3799 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0311 | 0.0725 |
Schistosoma mansoni | hexokinase | 0.0086 | 0.3799 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0311 | 0.0476 |
Loa Loa (eye worm) | hexokinase | 0.0086 | 0.3799 | 0.5806 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0783 | 0.0486 |
Leishmania major | hexokinase, putative | 0.0086 | 0.3799 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.1563 | 0.1292 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.1563 | 0.239 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.0311 | 0.0725 |
Echinococcus multilocularis | hexokinase | 0.0086 | 0.3799 | 0.3599 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.11 | 0.0814 |
Echinococcus multilocularis | geminin | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0054 | 0.1749 | 0.2673 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0129 | 0.6578 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.1563 | 0.4055 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.6543 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0116 | 0.5747 | 0.8342 |
Echinococcus multilocularis | hexokinase | 0.0086 | 0.3799 | 0.3599 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0116 | 0.5747 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0129 | 0.6578 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0082 | 0.3537 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0047 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.205 | 0.3133 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0103 | 0.4892 | 0.4728 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0065 | 0.2455 | 0.3753 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0129 | 0.6578 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0086 | 0.3799 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0086 | 0.3799 | 1 |
Brugia malayi | glutathione reductase | 0.0051 | 0.1563 | 0.239 |
Onchocerca volvulus | 0.0054 | 0.1749 | 0.4122 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0735 | 0.0437 |
Loa Loa (eye worm) | hexokinase | 0.0086 | 0.3799 | 0.5806 |
Plasmodium falciparum | hexokinase | 0.0086 | 0.3799 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0735 | 0.0437 |
Echinococcus granulosus | hexokinase | 0.0086 | 0.3799 | 0.3599 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0311 | 0.0725 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.11 | 0.0814 |
Brugia malayi | Hexokinase family protein | 0.0086 | 0.3799 | 0.5806 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0103 | 0.4892 | 0.4728 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0735 | 0.1123 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0311 | 0.0476 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.6543 | 1 |
Onchocerca volvulus | 0.0086 | 0.3799 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.