Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0287 | 0.0093 |
Trichomonas vaginalis | rap1 and, putative | 0.0057 | 0.0604 | 0.0638 |
Echinococcus multilocularis | ras gtpase | 0.0057 | 0.0604 | 0.0417 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0139 | 0.1849 | 0.4273 |
Brugia malayi | DNA topoisomerase I | 0.0186 | 0.2553 | 0.8904 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0314 | 0.0447 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0139 | 0.1849 | 0.3913 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.327 | 0.7792 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.0217 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0604 | 0.1543 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0067 | 0.0159 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0314 | 0.0447 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0141 | 0.1872 | 0.8675 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0681 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1875 | 0.3978 |
Brugia malayi | Ras protein let-60 | 0.0057 | 0.0604 | 0.1543 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0366 | 0.0435 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.1033 | 0.472 |
Plasmodium falciparum | topoisomerase I | 0.0186 | 0.2553 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0383 | 0.0176 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.2843 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1875 | 0.4335 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.2843 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0314 | 0.0503 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.4237 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0195 | 0.0017 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0057 | 0.0604 | 0.1543 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Trichomonas vaginalis | dexras1, putative | 0.0057 | 0.0604 | 0.0638 |
Trichomonas vaginalis | rheb, putative | 0.0057 | 0.0604 | 0.0638 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.1033 | 0.472 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0134 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.1875 | 0.4424 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2176 | 0.748 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0057 | 0.0604 | 0.0638 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0314 | 0.0741 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0047 | 0.0456 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0217 | 0.0081 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0134 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0186 | 0.2553 | 0.2404 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0314 | 0.0503 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0383 | 0.0176 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Brugia malayi | polk-prov protein | 0.0031 | 0.0217 | 0.0081 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0288 | 0.4092 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0134 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.2114 | 1 |
Echinococcus granulosus | ras gtpase | 0.0057 | 0.0604 | 0.0433 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0314 | 0.0447 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0287 | 0.011 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0287 | 0.0345 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0186 | 0.2553 | 0.2417 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0366 | 0.0435 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0474 | 0.0285 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0139 | 0.1849 | 0.4364 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0047 | 0.0456 | 0.0932 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.1033 | 0.472 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.4237 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0139 | 0.1849 | 0.1686 |
Brugia malayi | hypoxia-induced factor 1 | 0.0149 | 0.1988 | 0.6771 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0366 | 0.0864 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0321 | 0.0128 |
Trichomonas vaginalis | ral, putative | 0.0057 | 0.0604 | 0.0638 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0141 | 0.1872 | 1 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0057 | 0.0604 | 0.1543 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0521 | 0.0527 |
Brugia malayi | hypothetical protein | 0.0161 | 0.2176 | 0.748 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.4237 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0366 | 0.0864 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0186 | 0.2553 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0149 | 0.1988 | 0.6771 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0139 | 0.1849 | 0.1686 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0047 | 0.0456 | 0.1076 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0314 | 0.0503 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.1033 | 0.472 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0681 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.4237 | 1 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0057 | 0.0604 | 0.0638 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0475 | 0.1188 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.0268 | 0.0631 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.0217 | 0.0512 |
Onchocerca volvulus | 0.0036 | 0.0287 | 0.0297 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.1176 | 0.5418 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0321 | 0.0145 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0314 | 0.0447 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0186 | 0.2553 | 0.8904 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.1176 | 0.1705 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0134 |
Plasmodium vivax | topoisomerase I, putative | 0.0186 | 0.2553 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.1033 | 0.472 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.2114 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0366 | 0.0174 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0314 | 0.0591 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.1033 | 0.472 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0474 | 0.0285 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.0268 | 0.0631 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.1176 | 0.5418 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0366 | 0.0191 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0474 | 0.1054 |
Onchocerca volvulus | 0.0234 | 0.327 | 1 | |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0141 | 0.1872 | 0.8817 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0383 | 0.0176 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.1176 | 0.5418 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0186 | 0.2553 | 0.2404 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0288 | 0.4092 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.0314 | 0.1205 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.4092 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0383 | 0.0903 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0366 | 0.0864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.