Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0437 | 0.466 | 0.5068 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Trypanosoma brucei | glucosidase, putative | 0.0149 | 0.1199 | 0.2049 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0122 | 0.0122 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.2952 | 0.2952 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.1073 | 0.1121 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0149 | 0.1199 | 0.1881 |
Schistosoma mansoni | tyrosinase precursor | 0.0187 | 0.1658 | 0.1764 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0078 | 0.034 | 0.0341 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.034 | 0.0453 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0281 | 0.279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.4328 | 0.4328 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0085 | 0.043 | 0.043 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0149 | 0.1199 | 0.1199 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0149 | 0.1199 | 0.1881 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0324 | 0.3306 | 0.8342 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Onchocerca volvulus | 0.0544 | 0.5947 | 0.7029 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0409 | 0.4328 | 0.4297 |
Trichomonas vaginalis | glutaminase, putative | 0.0555 | 0.6086 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0361 | 0.3742 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0301 | 0.3028 | 0.299 |
Loa Loa (eye worm) | glutaminase | 0.0555 | 0.6086 | 0.6086 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0139 | 0.1073 | 0.1073 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0375 | 0.3913 | 0.639 |
Mycobacterium tuberculosis | Probable reductase | 0.0324 | 0.3306 | 0.8342 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0324 | 0.3306 | 0.8342 |
Loa Loa (eye worm) | glutamate receptor | 0.0332 | 0.3404 | 0.3404 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0149 | 0.1199 | 0.1151 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0324 | 0.3306 | 0.8342 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0139 | 0.1081 | 0.1684 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.034 | 0.034 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0149 | 0.1199 | 0.1151 |
Brugia malayi | glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Schistosoma mansoni | alpha-glucosidase | 0.0809 | 0.9141 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 0.3507 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.043 | 0.043 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0149 | 0.1199 | 0.2049 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.034 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0138 | 0.0138 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Brugia malayi | chromobox protein homolog 3 | 0.0078 | 0.034 | 0.0287 |
Onchocerca volvulus | 0.0061 | 0.0138 | 0.01 | |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.1618 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0136 | 0.1041 | 0.0992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0542 | 0.5925 | 0.5925 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0078 | 0.034 | 0.0453 |
Brugia malayi | glutaminase DH11.1 | 0.0555 | 0.6086 | 0.6065 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.2862 |
Plasmodium falciparum | thioredoxin reductase | 0.0142 | 0.1116 | 0.5 |
Brugia malayi | Ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0149 | 0.1199 | 0.2049 |
Trypanosoma brucei | polo-like protein kinase | 0.0281 | 0.279 | 0.5842 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0361 | 0.3742 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0555 | 0.6086 | 0.6086 |
Echinococcus granulosus | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0278 | 0.2755 | 0.2972 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0278 | 0.2755 | 0.2715 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0437 | 0.466 | 0.4631 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0881 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0378 | 0.3952 | 0.429 |
Echinococcus multilocularis | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Giardia lamblia | Ceramide glucosyltransferase | 0.034 | 0.35 | 1 |
Giardia lamblia | Kinase, PLK | 0.0281 | 0.279 | 0.7113 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0437 | 0.466 | 0.4631 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0324 | 0.3306 | 0.8342 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Schistosoma mansoni | alpha-glucosidase | 0.0809 | 0.9141 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0437 | 0.466 | 0.5068 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0375 | 0.3913 | 0.639 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Mycobacterium ulcerans | glutaminase | 0.0555 | 0.6086 | 0.5 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0136 | 0.1041 | 0.0992 |
Schistosoma mansoni | kinase | 0.0143 | 0.1126 | 0.1179 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Brugia malayi | ShTK domain containing protein | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0149 | 0.1199 | 0.1881 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0139 | 0.1081 | 0.1684 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0768 | 0.8646 | 0.8638 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0324 | 0.3306 | 0.8342 |
Loa Loa (eye worm) | glutamate receptor | 0.0131 | 0.0979 | 0.0979 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0332 | 0.3404 | 0.3368 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0281 | 0.279 | 0.3011 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.0308 | 0.0279 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0084 | 0.0411 | 0.0426 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0187 | 0.1658 | 0.1612 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0281 | 0.279 | 0.2751 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1658 | 0.1658 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.9227 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0187 | 0.1658 | 0.1658 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 0.3507 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0437 | 0.466 | 0.4631 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0162 | 0.1354 | 0.1431 |
Echinococcus multilocularis | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0411 | 0.0571 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0078 | 0.034 | 0.0453 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0281 | 0.279 | 0.2751 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Trypanosoma brucei | trypanothione reductase | 0.0142 | 0.1116 | 0.1849 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0162 | 0.1354 | 0.1307 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0078 | 0.034 | 0.0453 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0142 | 0.1116 | 0.1849 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0136 | 0.1041 | 0.0992 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0542 | 0.5925 | 0.5903 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Brugia malayi | Heterochromatin protein 1 | 0.0139 | 0.1073 | 0.1024 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1509 | 0.16 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0142 | 0.1116 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Leishmania major | alpha glucosidase II subunit, putative | 0.0149 | 0.1199 | 0.2049 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0751 | 0.8438 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0149 | 0.1199 | 0.1151 |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.1073 | 0.1671 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0149 | 0.1199 | 0.1881 |
Trichomonas vaginalis | conserved hypothetical protein | 0.007 | 0.0245 | 0.0295 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0078 | 0.034 | 0.0341 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0587 | 0.0586 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0409 | 0.4328 | 0.4297 |
Schistosoma mansoni | tyrosinase precursor | 0.0187 | 0.1658 | 0.1764 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0411 | 0.0571 |
Schistosoma mansoni | alpha glucosidase | 0.0149 | 0.1199 | 0.126 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.8438 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0281 | 0.279 | 0.2751 |
Loa Loa (eye worm) | amylo-alpha-1,6-glucosidase | 0.0066 | 0.0202 | 0.0202 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0361 | 0.3742 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0281 | 0.279 | 0.279 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0437 | 0.466 | 0.4631 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.1073 | 0.1121 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1658 | 0.1658 |
Loa Loa (eye worm) | glutathione reductase | 0.0142 | 0.1116 | 0.1116 |
Leishmania major | trypanothione reductase | 0.0142 | 0.1116 | 0.1849 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0356 | 0.3683 | 0.4328 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0054 | 0.0054 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Schistosoma mansoni | glutaminase | 0.0555 | 0.6086 | 0.6638 |
Echinococcus granulosus | expressed protein | 0.0768 | 0.8646 | 0.8638 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.1073 | 0.1671 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0187 | 0.1658 | 0.1658 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.1618 |
Plasmodium falciparum | glutathione reductase | 0.0142 | 0.1116 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.034 | 0.034 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Leishmania major | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0187 | 0.1658 | 0.1658 |
Toxoplasma gondii | thioredoxin reductase | 0.0142 | 0.1116 | 0.4695 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0281 | 0.279 | 0.3263 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0142 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0085 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1041 | 0.1041 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0278 | 0.2755 | 0.2715 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0078 | 0.034 | 0.0287 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Brugia malayi | Thioredoxin reductase | 0.0142 | 0.1116 | 0.1067 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.9227 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0361 | 0.3742 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0085 | 0.043 | 0.0378 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Plasmodium vivax | glutathione reductase, putative | 0.0142 | 0.1116 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.