Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0624 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0252 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0272 | 0.0556 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0401 | 0.402 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0272 | 0.0556 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0624 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0624 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0624 | 1 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0272 | 0.0556 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0624 | 1 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0401 | 0.402 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0624 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0624 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.