Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | polo-like protein kinase | 0.0281 | 0.279 | 0.5842 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0361 | 0.3742 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0149 | 0.1199 | 0.2049 |
Echinococcus granulosus | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0278 | 0.2755 | 0.2972 |
Loa Loa (eye worm) | glutaminase 2 | 0.0555 | 0.6086 | 0.6086 |
Brugia malayi | glutaminase DH11.1 | 0.0555 | 0.6086 | 0.6065 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.2862 |
Plasmodium falciparum | thioredoxin reductase | 0.0142 | 0.1116 | 0.5 |
Brugia malayi | Ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Brugia malayi | chromobox protein homolog 3 | 0.0078 | 0.034 | 0.0287 |
Onchocerca volvulus | 0.0061 | 0.0138 | 0.01 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0136 | 0.1041 | 0.0992 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.1618 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0078 | 0.034 | 0.0453 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0542 | 0.5925 | 0.5925 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.043 | 0.043 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0149 | 0.1199 | 0.2049 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 0.3507 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.034 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0138 | 0.0138 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0139 | 0.1081 | 0.1684 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0149 | 0.1199 | 0.1881 |
Echinococcus multilocularis | expressed protein | 0.0768 | 0.8646 | 0.8638 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0324 | 0.3306 | 0.8342 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0131 | 0.0979 | 0.0979 |
Mycobacterium ulcerans | glutaminase | 0.0555 | 0.6086 | 0.5 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0136 | 0.1041 | 0.0992 |
Schistosoma mansoni | kinase | 0.0143 | 0.1126 | 0.1179 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Brugia malayi | ShTK domain containing protein | 0.0187 | 0.1658 | 0.1612 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0324 | 0.3306 | 0.8342 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0437 | 0.466 | 0.5068 |
Schistosoma mansoni | alpha-glucosidase | 0.0809 | 0.9141 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0375 | 0.3913 | 0.639 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0881 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0437 | 0.466 | 0.4631 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0278 | 0.2755 | 0.2715 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0378 | 0.3952 | 0.429 |
Echinococcus multilocularis | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Giardia lamblia | Ceramide glucosyltransferase | 0.034 | 0.35 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0437 | 0.466 | 0.4631 |
Giardia lamblia | Kinase, PLK | 0.0281 | 0.279 | 0.7113 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0085 | 0.043 | 0.043 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0149 | 0.1199 | 0.1199 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0149 | 0.1199 | 0.1881 |
Schistosoma mansoni | tyrosinase precursor | 0.0187 | 0.1658 | 0.1764 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0281 | 0.279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.034 | 0.0453 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0078 | 0.034 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.4328 | 0.4328 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0122 | 0.0122 |
Trypanosoma brucei | glucosidase, putative | 0.0149 | 0.1199 | 0.2049 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.2952 | 0.2952 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0149 | 0.1199 | 0.1881 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.1073 | 0.1121 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0437 | 0.466 | 0.5068 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0139 | 0.1081 | 0.1684 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.034 | 0.034 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Brugia malayi | glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0149 | 0.1199 | 0.1151 |
Schistosoma mansoni | alpha-glucosidase | 0.0809 | 0.9141 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0332 | 0.3404 | 0.3404 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0324 | 0.3306 | 0.8342 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0149 | 0.1199 | 0.1151 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0324 | 0.3306 | 0.8342 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0361 | 0.3742 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0301 | 0.3028 | 0.299 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0375 | 0.3913 | 0.639 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0139 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | glutaminase | 0.0555 | 0.6086 | 0.6086 |
Mycobacterium tuberculosis | Probable reductase | 0.0324 | 0.3306 | 0.8342 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0324 | 0.3306 | 0.8342 |
Trichomonas vaginalis | glutaminase, putative | 0.0555 | 0.6086 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0409 | 0.4328 | 0.4297 |
Onchocerca volvulus | 0.0544 | 0.5947 | 0.7029 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus granulosus | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0142 | 0.1116 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.034 | 0.034 |
Leishmania major | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.1618 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0187 | 0.1658 | 0.1658 |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.1073 | 0.1671 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0356 | 0.3683 | 0.4328 |
Leishmania major | trypanothione reductase | 0.0142 | 0.1116 | 0.1849 |
Schistosoma mansoni | glutaminase | 0.0555 | 0.6086 | 0.6638 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0054 | 0.0054 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Echinococcus granulosus | expressed protein | 0.0768 | 0.8646 | 0.8638 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0361 | 0.3742 | 1 |
Loa Loa (eye worm) | amylo-alpha-1,6-glucosidase | 0.0066 | 0.0202 | 0.0202 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.1073 | 0.1121 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0437 | 0.466 | 0.4631 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0281 | 0.279 | 0.279 |
Loa Loa (eye worm) | glutathione reductase | 0.0142 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1658 | 0.1658 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0085 | 0.043 | 0.0378 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Plasmodium vivax | glutathione reductase, putative | 0.0142 | 0.1116 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0078 | 0.034 | 0.0287 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0361 | 0.3742 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0142 | 0.1116 | 0.1067 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.9227 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0085 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1041 | 0.1041 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0278 | 0.2755 | 0.2715 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0281 | 0.279 | 0.3263 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0187 | 0.1658 | 0.1658 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Toxoplasma gondii | thioredoxin reductase | 0.0142 | 0.1116 | 0.4695 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0142 | 0.1116 | 0.1116 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0162 | 0.1354 | 0.1307 |
Trypanosoma brucei | trypanothione reductase | 0.0142 | 0.1116 | 0.1849 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0078 | 0.034 | 0.0453 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0411 | 0.0571 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0078 | 0.034 | 0.0453 |
Echinococcus multilocularis | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0281 | 0.279 | 0.2751 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.9227 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1658 | 0.1658 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 0.3507 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0187 | 0.1658 | 0.1658 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0437 | 0.466 | 0.4631 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0162 | 0.1354 | 0.1431 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0332 | 0.3404 | 0.3368 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0084 | 0.0411 | 0.0426 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.0308 | 0.0279 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0281 | 0.279 | 0.3011 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0281 | 0.279 | 0.2751 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0187 | 0.1658 | 0.1612 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0281 | 0.279 | 0.2751 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0587 | 0.0586 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0409 | 0.4328 | 0.4297 |
Schistosoma mansoni | tyrosinase precursor | 0.0187 | 0.1658 | 0.1764 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.8438 |
Schistosoma mansoni | alpha glucosidase | 0.0149 | 0.1199 | 0.126 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0411 | 0.0571 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0751 | 0.8438 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0149 | 0.1199 | 0.2049 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0149 | 0.1199 | 0.1151 |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.1073 | 0.1671 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0149 | 0.1199 | 0.1881 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0078 | 0.034 | 0.0341 |
Trichomonas vaginalis | conserved hypothetical protein | 0.007 | 0.0245 | 0.0295 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0542 | 0.5925 | 0.5903 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0136 | 0.1041 | 0.0992 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0142 | 0.1116 | 0.1849 |
Brugia malayi | Heterochromatin protein 1 | 0.0139 | 0.1073 | 0.1024 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0142 | 0.1116 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1509 | 0.16 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.