Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0803 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0186 | 0.1152 | 0.2225 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0186 | 0.1152 | 1 |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0467 | 0.5176 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0186 | 0.1152 | 0.1152 |
Schistosoma mansoni | choline o-acyltransferase | 0.0106 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0186 | 0.1152 | 0.2225 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0467 | 0.5176 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0186 | 0.1152 | 0.2225 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0467 | 0.5176 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0467 | 0.5176 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0186 | 0.1152 | 0.2225 |
Schistosoma mansoni | choline o-acyltransferase | 0.0106 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0186 | 0.1152 | 0.1152 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0467 | 0.5176 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.