Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | peptidase, putative | 0.0068 | 0.0633 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0298 | 0.5229 | 0.5188 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0068 | 0.0633 | 0.0554 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0143 | 0.2136 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0068 | 0.0633 | 0.0554 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0068 | 0.0633 | 0.0554 |
Echinococcus granulosus | prolyl endopeptidase | 0.0298 | 0.5229 | 0.5188 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0598 | 0.0519 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0538 | 1 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0143 | 0.2136 | 0.3989 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0068 | 0.0633 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0199 | 0.3247 | 0.319 |
Echinococcus multilocularis | geminin | 0.0164 | 0.2562 | 0.2499 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0598 | 0.0519 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0199 | 0.3247 | 0.6148 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0143 | 0.2136 | 0.3989 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0143 | 0.2136 | 0.3989 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0068 | 0.0633 | 0.0554 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0598 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0633 | 0.0554 |
Toxoplasma gondii | hypothetical protein | 0.0068 | 0.0633 | 0.1067 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0068 | 0.0633 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0199 | 0.3247 | 0.6148 |
Trypanosoma brucei | prolyl endopeptidase | 0.0298 | 0.5229 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0199 | 0.3247 | 0.319 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0068 | 0.0633 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0068 | 0.0633 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0143 | 0.2136 | 0.55 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0598 | 0.0519 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.0598 | 0.0519 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0068 | 0.0633 | 0.1067 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.0598 | 0.0519 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2562 | 0.2499 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0298 | 0.5229 | 0.5188 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.0598 | 0.0519 |
Plasmodium vivax | hypothetical protein, conserved | 0.0068 | 0.0633 | 0.5 |
Leishmania major | oligopeptidase b | 0.0143 | 0.2136 | 0.3989 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.0598 | 0.0519 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0068 | 0.0633 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0143 | 0.2136 | 0.3989 |
Toxoplasma gondii | prolyl endopeptidase | 0.0298 | 0.5229 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0199 | 0.3247 | 0.6148 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0068 | 0.0633 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0298 | 0.5229 | 0.5188 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0298 | 0.5229 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.2562 | 0.2499 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0231 | 0.3884 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0538 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0068 | 0.0633 | 0.0554 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5229 | 0.5188 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0068 | 0.0633 | 0.0554 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0538 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0633 | 0.1067 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0143 | 0.2136 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0083 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0068 | 0.0633 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0068 | 0.0633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0598 | 0.0519 |
Brugia malayi | hypothetical protein | 0.0131 | 0.1902 | 0.1834 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0538 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0199 | 0.3247 | 0.6148 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0143 | 0.2136 | 0.3989 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1902 | 0.1834 |
Trypanosoma cruzi | oligopeptidase b | 0.0143 | 0.2136 | 0.3989 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0633 | 0.1067 |
Trypanosoma cruzi | oligopeptidase b | 0.0143 | 0.2136 | 0.3989 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2562 | 0.2499 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0298 | 0.5229 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0199 | 0.3247 | 0.319 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.0598 | 0.0519 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0143 | 0.2136 | 0.3989 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.0598 | 0.0519 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0199 | 0.3247 | 0.6148 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0068 | 0.0633 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0598 | 0.0519 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0143 | 0.2136 | 0.55 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.0598 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0633 | 0.0554 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0068 | 0.0633 | 0.1067 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0068 | 0.0633 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0199 | 0.3247 | 0.6148 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0298 | 0.5229 | 0.5188 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0633 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0199 | 0.3247 | 0.319 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0068 | 0.0633 | 0.0554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.