TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.377 | Formula: C19H18FN5O2
H donors: 1 H acceptors: 4 LogP: 1.47 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1ccc(n1)C)NCC1Cc2c(O1)c(cc(c2)F)c1cnccn1
InChi: 1S/C19H18FN5O2/c1-12-2-5-25(24-12)11-18(26)23-9-15-7-13-6-14(20)8-16(19(13)27-15)17-10-21-3-4-22-17/h2-6,8,10,15H,7,9,11H2,1H3,(H,23,26)
InChiKey: FJEQMXRTXMRBSY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	melatonin receptor type 1A	0.0044	0.0001	0.0001
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0001	0.0004
Plasmodium vivax	flap endonuclease 1, putative	0.0052	0.0048	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0048	0.0025	0.0028
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0044	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0255	0.1146	0.3885
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0044	0.0001	0.0004
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	G-protein coupled receptor	0.0044	0.0001	0.0001
Toxoplasma gondii	isocitrate dehydrogenase	0.0048	0.0025	0.0083
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0358	0.1702	0.577
Loa Loa (eye worm)	hypothetical protein	0.0588	0.295	0.3363
Brugia malayi	follicle stimulating hormone receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0358	0.1702	0.1941
Echinococcus multilocularis	orexin receptor type 2	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	fmrfamide receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	g-protein coupled receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Schistosoma mansoni	flap endonuclease-1	0.0047	0.002	0.0069
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0052	0.0048	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Brugia malayi	sulfakinin receptor protein	0.0044	0.0001	0.0001
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	dro:myosuppressin receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	amine GPCR	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0044	0.0001	0.0004
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.0001	0.0004
Brugia malayi	Melatonin receptor type 1A	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0048	0.0025	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	RE15519p	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Plasmodium vivax	SET domain protein, putative	0.0255	0.1146	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Schistosoma mansoni	histamine h1 receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	G protein coupled receptor 139	0.0044	0.0001	0.0004
Schistosoma mansoni	hypothetical protein	0.0044	0.0001	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.0001	0.0004
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	hypothetical protein	0.0044	0.0001	0.0004
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0255	0.1146	0.3885
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Echinococcus multilocularis	neuropeptide s receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0001	0.0004
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	7TM GPCR rhodopsin	0.0044	0.0001	0.0004
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0001	0.0004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.0001	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0001	0.0004
Brugia malayi	Dopamine receptor protein 2	0.0044	0.0001	0.0001
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.0001	0.0004
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0358	0.1702	0.577
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	neuropeptide s receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	hypothetical protein	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0588	0.295	1
Echinococcus granulosus	orexin receptor type 2	0.0044	0.0001	0.0004
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.1664	0.877	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0044	0.0001	0.0004
Plasmodium vivax	SET domain protein, putative	0.0588	0.295	1
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0588	0.295	1
Echinococcus granulosus	neuropeptide receptor	0.0044	0.0001	0.0004
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0048	0.0025	0.5157
Echinococcus granulosus	histone lysine methyltransferase setb	0.0255	0.1146	0.3885
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0255	0.1146	0.3885
Brugia malayi	Pre-SET motif family protein	0.1664	0.877	1
Plasmodium falciparum	flap endonuclease 1	0.0052	0.0048	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	Pre-SET motif family protein	0.0255	0.1146	0.1307
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0044	0.0001	0.0001
Entamoeba histolytica	Flap nuclease, putative	0.0052	0.0048	0.5
Brugia malayi	Protein set-1	0.0588	0.295	0.3363
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0227	0.0994	0.337
Echinococcus granulosus	G protein coupled receptor 139	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0255	0.1146	0.1307
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0044	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0255	0.1146	0.3885
Echinococcus granulosus	neuropeptide receptor A26	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	serotonin receptor	0.0044	0.0001	0.0004
Brugia malayi	G protein-coupled receptor F59B2.13	0.0044	0.0001	0.0001
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0048	0.0025	0.5157
Brugia malayi	isocitrate dehydrogenase	0.0048	0.0025	0.0028
Echinococcus multilocularis	isocitrate dehydrogenase	0.0048	0.0025	0.0083
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0588	0.295	1
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0048	0.0025	0.5157
Schistosoma mansoni	amine GPCR	0.0044	0.0001	0.0004
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0052	0.0048	0.0161
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0314	0.1466	0.497
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0052	0.0048	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.0001	0.0004
Brugia malayi	neuropeptide F receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0048	0.0025	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0358	0.1702	0.577
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0044	0.0001	0.0001
Giardia lamblia	Flap structure-specific endonuclease	0.0052	0.0048	0.028
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0048	0.0025	0.5157
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0044	0.0001	0.0004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	flap endonuclease-1	0.0052	0.0048	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	hypothetical protein	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	ORL1-like opioid receptor	0.0044	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0044	0.0001	0.0001
Brugia malayi	Dopamine receptor	0.0044	0.0001	0.0001
Echinococcus granulosus	somatostatin receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0001	0.0004
Schistosoma mansoni	neuropeptide f receptor 76f	0.0044	0.0001	0.0004
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0255	0.1146	0.3885
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0048	0.0025	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0044	0.0001	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Toxoplasma gondii	isocitrate dehydrogenase	0.0048	0.0025	0.0083
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0001	0.0004
Echinococcus multilocularis	sex peptide receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.0001	0.0001
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	growth hormone secretagogue receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0048	0.0025	0.0083
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	sex peptide receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	Serotonin receptor	0.0044	0.0001	0.0001
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0048	0.0025	0.0083
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0358	0.1702	0.577
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0255	0.1146	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.0001	0.0004
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0358	0.1702	0.577
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0255	0.1146	0.3885
Echinococcus multilocularis	serotonin receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	flap endonuclease 1	0.0052	0.0048	0.0161
Brugia malayi	Serotonin receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	opsin-like receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0044	0.0001	0.0004
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0358	0.1702	1
Echinococcus multilocularis	serotonin receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Schistosoma mansoni	amine GPCR	0.0044	0.0001	0.0004
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	Flap endonuclease-1	0.0052	0.0048	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0044	0.0001	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Echinococcus multilocularis	neuropeptide receptor A26	0.0044	0.0001	0.0004
Plasmodium falciparum	SET domain protein, putative	0.0588	0.295	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	dro:myosuppressin receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	opsin-like receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0358	0.1702	0.577
Schistosoma mansoni	myosin xvIII	0.0044	0.0001	0.0004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0044	0.0001	0.0004
Brugia malayi	larval opioid receptor	0.0044	0.0001	0.0001
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0588	0.295	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0044	0.0001	0.0004
Echinococcus multilocularis	flap endonuclease 1	0.0052	0.0048	0.0161
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0314	0.1466	0.1672
Echinococcus granulosus	allatostatin A receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.0001	0.0004
Brugia malayi	putative neuropeptide receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	neuropeptide receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	somatostatin receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0048	0.0025	0.0083
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Onchocerca volvulus		0.0255	0.1146	0.1145
Brugia malayi	putative neuropeptide receptor NPR1	0.0044	0.0001	0.0001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0001	0.0004
Brugia malayi	G-protein coupled receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	adenoreceptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0044	0.0001	0.0004
Brugia malayi	AKH receptor	0.0044	0.0001	0.0001
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.0001	0.0004
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0048	0.0025	0.0083
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0044	0.0001	0.0001
Echinococcus multilocularis	allatostatin A receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	amine GPCR	0.0044	0.0001	0.0004
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0048	0.0025	0.5157
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0044	0.0001	0.0001
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0044	0.0001	0.0004
Echinococcus granulosus	g-protein coupled receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.0001	0.0001
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0052	0.0048	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0044	0.0001	0.0004
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0044	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0044	0.0001	0.0004
Brugia malayi	Dopamine receptor protein 1	0.0044	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0044	0.0001	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.0001	0.0004
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0001	0.0004
Brugia malayi	G protein-coupled receptor	0.0044	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Brugia malayi	Isocitrate dehydrogenase	0.0048	0.0025	0.0028
Brugia malayi	neuropeptide F receptor	0.0044	0.0001	0.0001
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0044	0.0001	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0001	0.0004
Brugia malayi	hypothetical protein	0.0044	0.0001	0.0001
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0048	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0001	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0001	0.0004
Schistosoma mansoni	amine GPCR	0.0044	0.0001	0.0004
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0001	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0001	0.0004
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.0001	0.0004
Echinococcus granulosus	neuropeptide FF receptor 2	0.0044	0.0001	0.0004
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0044	0.0001	0.0001
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0314	0.1466	0.497
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0001	0.0004
Trichomonas vaginalis	set domain proteins, putative	0.1891	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0044	0.0001	0.0001
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0314	0.1466	0.1672
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0048	0.0025	0.0083
Trichomonas vaginalis	flap endonuclease-1, putative	0.0052	0.0048	0.0048
Brugia malayi	GnHR receptor homolog	0.0044	0.0001	0.0001
Schistosoma mansoni	opsin-like receptor	0.0044	0.0001	0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 810619