TDR Targets

Basic information

Technical information

TDR Targets ID: 810867
Name: 5-[(3-bromo-4-dimethylaminophenyl)methylidene ]-1,3-dimethyl-1,3-diazinane-2,4,6-trione
MW: 366.21 | Formula: C15H16BrN3O3
H donors: 0 H acceptors: 3 LogP: 2.14 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N(C)C(=O)C(=Cc2ccc(c(c2)Br)N(C)C)C(=O)N1C
InChi: 1S/C15H16BrN3O3/c1-17(2)12-6-5-9(8-11(12)16)7-10-13(20)18(3)15(22)19(4)14(10)21/h5-8H,1-4H3
InChiKey: CGMWQOIHYMLWKS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[(3-bromo-4-dimethylamino-phenyl)methylene]-1,3-dimethyl-hexahydropyrimidine-2,4,6-trione
5-[(3-bromo-4-dimethylaminophenyl)methylene]-1,3-dimethylhexahydropyrimidine-2,4,6-trione
5-(3-bromo-4-dimethylamino-benzylidene)-1,3-dimethyl-barbituric acid
5-[(3-bromo-4-dimethylamino-phenyl)methylidene]-1,3-dimethyl-1,3-diazinane-2,4,6-trione
ZINC01209688
CBMicro_007386
STOCK2S-35837
BIM-0007651.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	DnaJ domain containing protein	0.0064	0.1049	0.1018
Brugia malayi	hypothetical protein	0.011	0.2022	0.1994
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0379	0.0368
Echinococcus granulosus	polyADP ribose glycohydrolase	0.0492	1	1
Schistosoma mansoni	lamin	0.003	0.0335	0.0301
Brugia malayi	Pre-SET motif family protein	0.0033	0.0401	0.0368
Brugia malayi	hypothetical protein	0.005	0.0753	0.0721
Leishmania major	hypothetical protein, conserved	0.0036	0.046	0.5916
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0036	0.046	0.5916
Brugia malayi	hypothetical protein	0.0032	0.0384	0.035
Schistosoma mansoni	hypothetical protein	0.0069	0.1155	0.1125
Echinococcus multilocularis	dnaJ subfamily C 6	0.0064	0.1049	0.1039
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0036	0.046	0.5916
Echinococcus multilocularis	lamin	0.003	0.0335	0.0323
Schistosoma mansoni	hypothetical protein	0.0064	0.1049	0.1018
Schistosoma mansoni	poly(ADP-ribose) glycohydrolase	0.0492	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0753	0.0721
Schistosoma mansoni	hypothetical protein	0.0032	0.0379	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0379	0.0379
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0335	0.0301
Entamoeba histolytica	hypothetical protein	0.0219	0.4294	0.2847
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.1824	0.1796
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0035	0.0035
Echinococcus granulosus	intermediate filament protein	0.003	0.0335	0.0323
Toxoplasma gondii	poly(ADP-ribose) glycohydrolase	0.0219	0.4294	0.4274
Echinococcus multilocularis	poly(ADP ribose) glycohydrolase	0.0492	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0323	0.0323
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.065	0.0618
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0035	0.0023
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0401	0.0368
Entamoeba histolytica	poly(ADP-ribose) glycohydrolase, putative	0.0492	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.065	0.064
Trypanosoma brucei	poly(ADP-ribose) glycohydrolase, putative	0.0492	1	1
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0036	0.046	0.0427
Entamoeba histolytica	hypothetical protein	0.0492	1	1
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0753	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0035	0.5
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0045	0.001
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.065	0.065
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0401	0.039
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0401	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1155	0.1155
Schistosoma mansoni	intermediate filament proteins	0.003	0.0335	0.0301
Schistosoma mansoni	hypothetical protein	0.0032	0.0379	0.0345
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.065	0.064
Echinococcus granulosus	lamin dm0	0.003	0.0335	0.0323
Entamoeba histolytica	poly(ADP-ribose) glycohydrolase, putative	0.0219	0.4294	0.2847
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.065	0.0618
Toxoplasma gondii	poly(ADP-ribose) glycohydrolase	0.0492	1	1
Echinococcus granulosus	lamin	0.003	0.0335	0.0323
Schistosoma mansoni	hypothetical protein	0.011	0.2022	0.1994
Echinococcus multilocularis	musashi	0.003	0.0335	0.0323
Echinococcus multilocularis	geminin	0.0166	0.3193	0.3185
Onchocerca volvulus		0.0033	0.0401	0.0137
Schistosoma mansoni	hypothetical protein	0.0032	0.0379	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1824	0.1824
Loa Loa (eye worm)	Poly(ADP-ribose) glycohydrolase	0.0492	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.065	0.064
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0401	0.0368
Echinococcus granulosus	geminin	0.0166	0.3193	0.3185
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0401	0.0368
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0379	0.0368
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0753	0.0721
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0379	0.0345
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0036	0.046	0.0427
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.065	0.064
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0753	0.0721
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0401	0.0368
Schistosoma mansoni	hypothetical protein	0.0166	0.3193	0.3169
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0753	0.0721
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.011	0.2022	0.2013
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.1824	0.1824
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0036	0.046	0.0449
Brugia malayi	intermediate filament protein	0.003	0.0335	0.0301
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0064	0.1049	0.1049
Trypanosoma cruzi	poly(ADP-ribose) glycohydrolase, putative	0.0492	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0035	0.0023
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0335	0.0335
Onchocerca volvulus		0.0262	0.5195	1
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0036	0.046	0.0449
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0753	1
Schistosoma mansoni	transcription factor LCR-F1	0.011	0.2022	0.1994
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0045	0.0045
Schistosoma mansoni	hypothetical protein	0.0166	0.3193	0.3169
Loa Loa (eye worm)	hypothetical protein	0.005	0.0753	0.0753
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0178	0.0167
Brugia malayi	Augmenter of liver regeneration	0.0036	0.046	0.0427
Toxoplasma gondii	Erv1 / Alr family protein	0.0036	0.046	0.0427
Loa Loa (eye worm)	hepatopoietin HPO2	0.0036	0.046	0.046
Leishmania major	hypothetical protein, conserved	0.005	0.0753	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0376	0.0365
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.065	0.0618
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0035	0.0023
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.023	0.4529	0.4529
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0036	0.046	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0011	0.0011
Echinococcus multilocularis	lamin dm0	0.003	0.0335	0.0323
Trypanosoma cruzi	poly(ADP-ribose) glycohydrolase, putative	0.0492	1	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0379	0.0345
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0036	0.046	0.0427
Echinococcus granulosus	dnaJ subfamily C 6	0.0064	0.1049	0.1039
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0401	0.039
Loa Loa (eye worm)	hypothetical protein	0.003	0.0335	0.0335
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0035	0.0023
Echinococcus granulosus	GPCR family 2	0.0032	0.0379	0.0368
Trichomonas vaginalis	set domain proteins, putative	0.0262	0.5195	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0379	0.0368
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.011	0.2022	0.2013
Brugia malayi	Pre-SET motif family protein	0.023	0.4529	0.451
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0379	0.0368
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0035	0.0023
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0379	0.0368
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0401	0.039
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1155	0.1125
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0335	0.0335
Toxoplasma gondii	Erv1 / Alr family protein	0.0036	0.046	0.0427
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0035	0.0023
Schistosoma mansoni	hypothetical protein	0.0032	0.0379	0.0345
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.065	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0401	0.0401
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0753	1
Plasmodium vivax	SET domain protein, putative	0.0033	0.0401	0.5101
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.1824	0.1796
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0178	0.0167
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0379	0.0379
Schistosoma mansoni	hypothetical protein	0.0022	0.0178	0.0144
Schistosoma mansoni	lamin	0.003	0.0335	0.0301

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 810867