Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0072 | 0.022 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1161 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0188 | 0.1264 | 0.1264 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1161 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0188 | 0.1264 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0116 | 0.0622 | 0.0411 |
Trypanosoma brucei | lipase domain protein, putative | 0.1161 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0188 | 0.1264 | 0.1067 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0072 | 0.022 | 0.022 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0859 | 0.7294 | 1 |
Onchocerca volvulus | 0.1161 | 1 | 0.5 | |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0136 | 0.0798 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0072 | 0.022 | 0.022 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0136 | 0.0798 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1161 | 1 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0072 | 0.022 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.1161 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1161 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1161 | 1 | 0.5 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0188 | 0.1264 | 0.1067 |
Loa Loa (eye worm) | lipase | 0.1161 | 1 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.0065 | 0.0161 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0846 | 0.717 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1161 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.1161 | 1 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0188 | 0.1264 | 0.1067 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0188 | 0.1264 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0188 | 0.1264 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.