Detailed information for compound 811900

Basic information

Technical information
  • TDR Targets ID: 811900
  • Name: 2-(2-fluorophenyl)-3-phenyl-1,3-thiazolidin-4 -one
  • MW: 273.325 | Formula: C15H12FNOS
  • H donors: 0 H acceptors: 1 LogP: 3.46 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(N1c1ccccc1)c1ccccc1F
  • InChi: 1S/C15H12FNOS/c16-13-9-5-4-8-12(13)15-17(14(18)10-19-15)11-6-2-1-3-7-11/h1-9,15H,10H2
  • InChiKey: BIJMVHAQPBYXNT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-fluorophenyl)-3-phenyl-thiazolidin-4-one
  • 2-(2-fluorophenyl)-3-phenyl-4-thiazolidinone
  • AG-690/13706789
  • CBMicro_017537
  • BIM-0017327.P001
  • BAS 01370038
  • EU-0070390
  • RS-0214
  • 2-(2-Fluoro-phenyl)-3-phenyl-thiazolidin-4-one
  • CDS1_004033
  • DivK1c_005073
  • MLS000525495
  • SMR000115969

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0124 0.0567
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Mycobacterium ulcerans putative regultory protein 0.0033 0.0124 0.0124
Echinococcus multilocularis heat shock protein 90 0.0033 0.0124 0.026
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.021 0.021
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.021 0.0368
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0124 0.0218
Plasmodium vivax DNA gyrase subunit B, putative 0.1036 1 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0074 0.0533 0.0936
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0074 0.0533 0.0936
Schistosoma mansoni heat shock protein 0.0033 0.0124 0.0567
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.073 0.073
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.021 0.0959
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0074 0.0533 0.2438
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.0833 0.2222
Brugia malayi DNA topoisomerase III beta-1 0.0074 0.0533 0.2438
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0242 0.2187 1
Echinococcus granulosus muscleblind protein 0.0158 0.136 0.2855
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0033 0.0124 0.0124
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0033 0.0124 0.0567
Leishmania major developmentally regulated phosphoprotein-like protein 0.0033 0.0124 0.0218
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0242 0.2187 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0033 0.0124 0.0567
Trypanosoma cruzi DNA topoisomerase III, putative 0.0074 0.0533 0.0936
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0168 0.1458 0.2559
Trichomonas vaginalis receptor histidine kinase, putative 0.0033 0.0124 0.0567
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0074 0.0533 0.0533
Plasmodium vivax DNA topoisomerase II, putative 0.0242 0.2187 0.2187
Echinococcus multilocularis muscleblind protein 1 0.0158 0.136 0.2855
Toxoplasma gondii DNA topoisomerase 2, putative 0.0242 0.2187 0.3839
Schistosoma mansoni endoplasmin 0.0033 0.0124 0.0567
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0033 0.0124 0.0124
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0074 0.0533 0.1119
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.1036 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.028 0.0589
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0033 0.0124 0.0124
Plasmodium falciparum DNA topoisomerase 2 0.0242 0.2187 0.2187
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0074 0.0533 0.2438
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0033 0.0124 0.0567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.028 0.1283
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0033 0.0124 0.0567
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0464 0.2121
Mycobacterium ulcerans DNA topoisomerase I 0.0074 0.0533 0.0533
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0033 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0158 0.136 0.6218
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Echinococcus granulosus heat shock protein 90 0.0033 0.0124 0.026
Toxoplasma gondii thioredoxin reductase 0.0041 0.021 0.0368
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0033 0.0124 0.0567
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Chlamydia trachomatis DNA topoisomerase I 0.0074 0.0533 0.0414
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0074 0.0533 0.1282
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0033 0.0124 0.0124
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0215 0.0452
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Trypanosoma cruzi DNA topoisomerase II, putative 0.0168 0.1458 0.2559
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0464 0.2121
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0215 0.0452
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0124 0.0124
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.028 0.1283
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Trypanosoma brucei DNA topoisomerase ii 0.0599 0.5697 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.1036 1 1
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0124 0.0124
Plasmodium falciparum DNA gyrase subunit B 0.1036 1 1
Plasmodium vivax DNA topoisomerase 3, putative 0.0074 0.0533 0.0533
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0033 0.0124 0.0124
Echinococcus granulosus neuropeptide receptor A26 0.0504 0.4763 1
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0033 0.0124 0.0124
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.028 0.1283
Brugia malayi glutathione reductase 0.0041 0.021 0.0959
Leishmania major hypothetical protein, conserved 0.0033 0.0124 0.0218
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0599 0.5697 1
Giardia lamblia Pms1-like protein 0.0033 0.0124 0.0664
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0464 0.2121
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0124 0.0218
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0464 0.2121
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0074 0.0533 0.2438
Mycobacterium ulcerans DNA gyrase subunit B 0.1036 1 1
Brugia malayi Muscleblind-like protein 0.0158 0.136 0.6218
Loa Loa (eye worm) hypothetical protein 0.0168 0.1458 0.6667
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0074 0.0533 0.1119
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1036 1 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.1458 0.6667
Loa Loa (eye worm) TOPoisomerase family member 0.0242 0.2187 1
Leishmania major DNA topoisomerase III, putative 0.0074 0.0533 0.0936
Echinococcus multilocularis muscleblind protein 0.0158 0.136 0.2855
Mycobacterium ulcerans two component sensor kinase MprB 0.0033 0.0124 0.0124
Brugia malayi DNA topoisomerase III 0.0074 0.0533 0.2438
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0033 0.0124 0.0124
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0242 0.2187 1
Giardia lamblia DNA topoisomerase III 0.0074 0.0533 0.2855
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.0833 0.0833
Trypanosoma brucei DNA topoisomerase IA, putative 0.0074 0.0533 0.0936
Leishmania major trypanothione reductase 0.0041 0.021 0.0368
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0074 0.0533 0.0936
Brugia malayi Probable DNA topoisomerase II 0.0242 0.2187 1
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0124 0.0567
Plasmodium falciparum endoplasmin, putative 0.0033 0.0124 0.0124
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0242 0.2187 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.017 0.0776
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0599 0.5697 1
Echinococcus granulosus heat shock protein 0.0033 0.0124 0.026
Schistosoma mansoni DNA topoisomerase II 0.0242 0.2187 1
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Giardia lamblia DNA topoisomerase III 0.0074 0.0533 0.2855
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0124 0.0218
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0124 0.0567
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.073 0.073
Schistosoma mansoni endoplasmin 0.0033 0.0124 0.0567
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0033 0.0124 0.0124
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0033 0.0124 0.0124
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0242 0.2187 0.4591
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0033 0.0124 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.028 0.0589
Loa Loa (eye worm) glutathione reductase 0.0041 0.021 0.0959
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0033 0.0124 0.026
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0033 0.0124 0.0124
Schistosoma mansoni pyruvate dehydrogenase 0.0033 0.0124 0.0567
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0033 0.0124 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.028 0.0589
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0074 0.0533 0.2438
Mycobacterium tuberculosis Possible two component sensor kinase 0.0033 0.0124 0.0124
Echinococcus granulosus tar DNA binding protein 0.0067 0.0464 0.0974
Loa Loa (eye worm) hypothetical protein 0.0158 0.136 0.6218
Trichomonas vaginalis receptor histidine kinase, putative 0.0033 0.0124 0.0567
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Brugia malayi Thioredoxin reductase 0.0041 0.021 0.0959
Echinococcus granulosus neuropeptide s receptor 0.0504 0.4763 1
Trypanosoma brucei developmentally regulated phosphoprotein 0.0033 0.0124 0.0218
Plasmodium vivax glutathione reductase, putative 0.0041 0.021 0.021
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0599 0.5697 1
Brugia malayi RNA binding protein 0.0067 0.0464 0.2121
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0124 0.0218
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.028 0.0589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.028 0.1283
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0033 0.0124 0.026
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0033 0.0124 0.0124
Entamoeba histolytica DNA topoisomerase III, putative 0.0074 0.0533 0.2438
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.073 0.073
Schistosoma mansoni heat shock protein 0.0033 0.0124 0.0567
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Trypanosoma brucei DNA topoisomerase III, putative 0.0074 0.0533 0.0936
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0242 0.2187 0.4591
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0033 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0033 0.0124 0.0567
Trypanosoma brucei trypanothione reductase 0.0041 0.021 0.0368
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0168 0.1458 0.2559
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0339 0.1549
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0033 0.0124 0.0124
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0124 0.0218
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0124 0.0218
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0339 0.1549
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Brugia malayi kinase, mitochondrial precursor 0.0033 0.0124 0.0567
Echinococcus multilocularis heat shock protein 0.0033 0.0124 0.026
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0033 0.0124 0.026
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0124 0.0218
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Mycobacterium tuberculosis Probable reductase 0.0094 0.073 0.073
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0074 0.0533 0.2438
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0464 0.0974
Echinococcus multilocularis neuropeptide s receptor 0.0504 0.4763 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0242 0.2187 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.021 0.021
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0464 0.2121
Entamoeba histolytica DNA topoisomerase II, putative 0.0242 0.2187 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0339 0.1549
Plasmodium vivax endoplasmin, putative 0.0033 0.0124 0.0124
Brugia malayi GRF zinc finger family protein 0.0074 0.0533 0.2438
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0033 0.0124 0.0124
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0033 0.0124 0.0124
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0074 0.0533 0.1119
Treponema pallidum DNA topoisomerase I (topA) 0.0074 0.0533 0.0533
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0124 0.0664
Leishmania major mitochondrial DNA topoisomerase II 0.0599 0.5697 1
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0074 0.0533 0.0936
Mycobacterium tuberculosis Probable two component sensor kinase 0.0033 0.0124 0.0124
Leishmania major DNA topoisomerase III, putative 0.0074 0.0533 0.0936
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0094 0.073 0.1898
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0033 0.0124 0.0124
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0339 0.1549
Trichomonas vaginalis DNA topoisomerase II, putative 0.0242 0.2187 1
Plasmodium falciparum heat shock protein 90 0.0033 0.0124 0.0124
Brugia malayi Endoplasmin precursor 0.0033 0.0124 0.0567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.028 0.1283
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.0833 0.0833
Plasmodium falciparum thioredoxin reductase 0.0041 0.021 0.021
Echinococcus multilocularis neuropeptide receptor A26 0.0504 0.4763 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0033 0.0124 0.0124
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0033 0.0124 0.0124
Trypanosoma cruzi DNA topoisomerase II, putative 0.0168 0.1458 0.2559
Entamoeba histolytica DNA topoisomerase III, putative 0.0074 0.0533 0.2438
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0124 0.0218
Trypanosoma brucei DNA topoisomerase III, putative 0.0074 0.0533 0.0936
Brugia malayi TAR-binding protein 0.0067 0.0464 0.2121
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0033 0.0124 0.0124
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0033 0.0124 0.0124
Trypanosoma cruzi DNA topoisomerase III, putative 0.0074 0.0533 0.0936
Schistosoma mansoni hypothetical protein 0.0037 0.017 0.0776
Plasmodium falciparum glutathione reductase 0.0041 0.021 0.021
Mycobacterium ulcerans two component regulator - sensor kinase 0.0033 0.0124 0.0124
Loa Loa (eye worm) DNA topoisomerase III 0.0074 0.0533 0.2438
Trypanosoma brucei heat shock protein, putative 0.0033 0.0124 0.0218
Leishmania major DNA topoisomerase ii 0.0168 0.1458 0.2559
Echinococcus multilocularis rho GTPase activating protein 20 0.0074 0.0533 0.1119
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0464 0.2121
Toxoplasma gondii DNA topoisomerase family protein 0.0074 0.0533 0.0936
Mycobacterium tuberculosis Conserved protein 0.0033 0.0124 0.0124
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Leishmania major heat shock protein 83-1 0.0033 0.0124 0.0218
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0124 0.0218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.073 0.073
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0124 0.0567
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0124 0.0218
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0357 0.3314 1
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0124 0.0218
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0464 0.2121
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0124 0.0567
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0124 0.0218
Loa Loa (eye worm) RNA binding protein 0.0067 0.0464 0.2121
Chlamydia trachomatis DNA gyrase subunit B 0.068 0.649 0.6446
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.073 0.073
Leishmania major DNA topoisomerase 1A 0.0074 0.0533 0.0936
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.0833 0.0833
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0124 0.0218
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0124 0.0218
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0124 0.0218
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0124 0.0567
Giardia lamblia DNA topoisomerase II 0.021 0.1867 1
Loa Loa (eye worm) endoplasmin 0.0033 0.0124 0.0567
Trichomonas vaginalis sensor histidine kinase, putative 0.0033 0.0124 0.0567
Plasmodium falciparum DNA topoisomerase 3, putative 0.0074 0.0533 0.0533
Brugia malayi heat shock protein 90 0.0033 0.0124 0.0567
Loa Loa (eye worm) hypothetical protein 0.0037 0.017 0.0776
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0464 0.2121

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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