TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.448 | Formula: C23H24N2O4
H donors: 0 H acceptors: 2 LogP: 2.42 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COCc1ccc(o1)C(=O)N1CCC(=O)N(CC1)Cc1ccc2c(c1)cccc2
InChi: 1S/C23H24N2O4/c1-28-16-20-8-9-21(29-20)23(27)24-11-10-22(26)25(13-12-24)15-17-6-7-18-4-2-3-5-19(18)14-17/h2-9,14H,10-13,15-16H2,1H3
InChiKey: QRDAIERCEJXLLU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.1073	0.4112	1
Trichomonas vaginalis	conserved hypothetical protein	0.2589	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0005	0.0021
Schistosoma mansoni	tubulin subunit alpha	0.0017	0.0013	0.0031
Brugia malayi	bZIP transcription factor family protein	0.0095	0.0316	0.5308
Leishmania major	carbonic anhydrase family protein, putative	0.1073	0.4112	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0015	0.0005	0.0021
Echinococcus multilocularis	tubulin alpha 1C chain	0.0017	0.0013	0.0057
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0139	0.2353
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0029	0.0056	0.0956
Entamoeba histolytica	hypothetical protein	0.0039	0.0098	0.0207
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0015	0.0005	0.0081
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.0177	0.0778
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.1024	0.3923	0.3344
Treponema pallidum	ATP-binding protein (ylxH-1)	0.0431	0.1618	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0015	0.0005	0.0081
Brugia malayi	Tubulin alpha-2 chain	0.0017	0.0013	0.0139
Schistosoma mansoni	hypothetical protein	0.0166	0.0591	0.1436
Entamoeba histolytica	carbonic anhydrase, putative	0.1073	0.4112	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0131	0.0455	0.7704
Plasmodium vivax	sulfate transporter, putative	0.0069	0.0213	0.3471
Echinococcus granulosus	Tubulin alpha 1 chain	0.0017	0.0013	0.0057
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0015	0.0005	0.0021
Brugia malayi	Furin-like cysteine rich region family protein	0.006	0.0177	0.294
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0095	0.0316	0.1388
Echinococcus granulosus	carbonic anhydrase II	0.0126	0.0434	0.1906
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0013	0.0218
Echinococcus granulosus	lipoxygenase domain containing protein	0.0166	0.0591	0.2597
Echinococcus multilocularis	tubulin alpha chain	0.0017	0.0013	0.0057
Brugia malayi	RNA binding protein	0.0069	0.0214	0.3565
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.2066	0.7968	1
Plasmodium falciparum	LCCL domain-containing protein	0.0166	0.0591	1
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0069	0.0213	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0166	0.0591	0.2597
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0131	0.0455	0.2
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0214	0.052
Schistosoma mansoni	tubulin subunit alpha	0.0017	0.0013	0.0031
Schistosoma mansoni	rab6-interacting	0.0166	0.0591	0.1436
Chlamydia trachomatis	sulfate transporter	0.0069	0.0213	0.5
Leishmania major	carbonic anhydrase-like protein	0.0126	0.0434	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0056	0.0956
Schistosoma mansoni	hypothetical protein	0.0029	0.0056	0.0137
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0015	0.0005	0.0021
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0005	0.0021
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.06	0.2274	1
Echinococcus multilocularis	RUN	0.0166	0.0591	0.2597
Brugia malayi	Tubulin alpha chain	0.0017	0.0013	0.0139
Schistosoma mansoni	rab6-interacting	0.0166	0.0591	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0126	0.0434	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0015	0.0005	0.0021
Schistosoma mansoni	alpha tubulin	0.0017	0.0013	0.0031
Echinococcus multilocularis	tubulin alpha 3 chain	0.0017	0.0013	0.0057
Plasmodium vivax	multidomain scavenger receptor, putative	0.0166	0.0591	1
Echinococcus granulosus	tubulin alpha chain	0.0017	0.0013	0.0057
Echinococcus granulosus	FTZ F1 alpha	0.0015	0.0005	0.0021
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0214	0.052
Echinococcus granulosus	tubulin subunit TubB	0.0017	0.0013	0.0057
Echinococcus granulosus	tubulin alpha chain	0.0017	0.0013	0.0057
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0015	0.0005	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Echinococcus granulosus	tubulin alpha chain	0.0017	0.0013	0.0057
Brugia malayi	Tubulin alpha-2 chain	0.0017	0.0013	0.0139
Schistosoma mansoni	hypothetical protein	0.0039	0.0098	0.0237
Brugia malayi	hypothetical protein	0.0039	0.0098	0.1584
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0015	0.0005	0.0081
Echinococcus granulosus	tubulin alpha 1C chain	0.0017	0.0013	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0056	0.0956
Echinococcus granulosus	carbonic anhydrase	0.0029	0.0056	0.0248
Schistosoma mansoni	RAR-like nuclear receptor	0.0015	0.0005	0.0012
Schistosoma mansoni	carbonic anhydrase	0.1073	0.4112	1
Echinococcus multilocularis	tubulin subunit TubB	0.0017	0.0013	0.0057
Loa Loa (eye worm)	steroid hormone receptor	0.0015	0.0005	0.0081
Toxoplasma gondii	hypothetical protein	0.0029	0.0056	0.2173
Schistosoma mansoni	alpha tubulin	0.0017	0.0013	0.0031
Entamoeba histolytica	hypothetical protein	0.0039	0.0098	0.0207
Echinococcus multilocularis	jun protein	0.0095	0.0316	0.1388
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0095	0.0316	0.1388
Mycobacterium ulcerans	hypothetical protein	0.0119	0.0405	0.0196
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0015	0.0005	0.0021
Trypanosoma brucei	carbonic anhydrase-like protein	0.0126	0.0434	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0015	0.0005	0.0081
Echinococcus granulosus	jun protein	0.0095	0.0316	0.1388
Echinococcus multilocularis	insulin receptor	0.0131	0.0455	0.2
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0166	0.0591	0.2597
Schistosoma mansoni	hypothetical protein	0.0078	0.0249	0.0606
Schistosoma mansoni	tyrosine kinase	0.0131	0.0455	0.1107
Echinococcus multilocularis	tubulin alpha 1C chain	0.0017	0.0013	0.0057
Schistosoma mansoni	coup transcription factor	0.0015	0.0005	0.0012
Echinococcus multilocularis	tubulin alpha 3 chain	0.0017	0.0013	0.0057
Brugia malayi	hypothetical protein	0.0166	0.0591	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0126	0.0434	0.7342
Echinococcus multilocularis	tubulin alpha chain	0.0017	0.0013	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.2589	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0015	0.0005	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0591	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0291	0.4932
Schistosoma mansoni	loxhd1	0.0166	0.0591	0.1436
Echinococcus multilocularis	Polycystic kidney disease protein	0.0166	0.0591	0.2597
Schistosoma mansoni	carbonic anhydrase-related	0.0029	0.0056	0.0137
Echinococcus granulosus	ecdysone induced protein 78C	0.0015	0.0005	0.0021
Schistosoma mansoni	tyrosine kinase	0.0131	0.0455	0.1107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0139	0.0338
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0015	0.0005	0.0012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0015	0.0005	0.0081
Echinococcus granulosus	RUN	0.0166	0.0591	0.2597
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0139	0.0611
Echinococcus multilocularis	tubulin alpha chain	0.0017	0.0013	0.0057
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0069	0.0213	0.4766
Echinococcus granulosus	insulin receptor	0.0131	0.0455	0.2
Loa Loa (eye worm)	TK/EGFR protein kinase	0.006	0.0177	0.2997
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.0224	0.0985
Giardia lamblia	Alpha-tubulin	0.0017	0.0013	0.5
Echinococcus granulosus	Tubulin alpha 1 chain	0.0017	0.0013	0.0057
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0214	0.0939
Schistosoma mansoni	retinoic acid receptor RXR	0.0015	0.0005	0.0012
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0015	0.0005	0.0021
Schistosoma mansoni	jun-related protein	0.0078	0.0249	0.0606
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0015	0.0005	0.0012
Entamoeba histolytica	hypothetical protein	0.0039	0.0098	0.0207
Loa Loa (eye worm)	tubulin alpha chain	0.0017	0.0013	0.0218
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0015	0.0005	0.0012
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0005	0.0021
Echinococcus multilocularis	carbonic anhydrase	0.0029	0.0056	0.0248
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.0177	0.0778
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0098	0.0237
Onchocerca volvulus		0.0166	0.0591	0.3606
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0029	0.0056	0.0882
Echinococcus multilocularis	carbonic anhydrase II	0.0126	0.0434	0.1906
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0017	0.0013	0.0057
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.0224	0.0985
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0139	0.0338
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0126	0.0434	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0029	0.0056	0.0882
Onchocerca volvulus	Putative sulfate transporter	0.0434	0.1629	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0017	0.0013	0.0057
Schistosoma mansoni	tyrosine kinase	0.0059	0.0173	0.0421
Brugia malayi	Doublecortin family protein	0.0166	0.0591	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0015	0.0005	0.0081
Schistosoma mansoni	tubulin subunit alpha	0.0017	0.0013	0.0031
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0214	0.052
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0017	0.0013	0.0057
Loa Loa (eye worm)	alpha-tubulin	0.0017	0.0013	0.0218
Echinococcus granulosus	Polycystic kidney disease protein	0.0166	0.0591	0.2597
Brugia malayi	Protein kinase domain containing protein	0.0073	0.0227	0.3796
Echinococcus granulosus	carbonic anhydrase	0.0029	0.0056	0.0248
Echinococcus multilocularis	carbonic anhydrase	0.0029	0.0056	0.0248
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0015	0.0005	0.0021
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0069	0.0213	0.4766
Giardia lamblia	Alpha-tubulin	0.0017	0.0013	0.5
Schistosoma mansoni	tyrosine kinase	0.0059	0.0173	0.0421
Schistosoma mansoni	carbonic anhydrase-related	0.0029	0.0056	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0223	0.3776
Echinococcus granulosus	tubulin alpha 3 chain	0.0017	0.0013	0.0057
Echinococcus granulosus	lipoxygenase domain containing protein	0.0166	0.0591	0.2597
Plasmodium falciparum	carbonic anhydrase	0.0029	0.0056	0.0754
Schistosoma mansoni	tyrosine kinase	0.006	0.0177	0.0431
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0069	0.0213	0.3471
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0214	0.052
Brugia malayi	tubulin alpha chain - mouse	0.0017	0.0013	0.0139
Echinococcus multilocularis	tubulin alpha chain	0.0017	0.0013	0.0057
Schistosoma mansoni	lipoxygenase	0.0301	0.1113	0.2706
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Schistosoma mansoni	tyrosine kinase	0.006	0.0177	0.0431
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0015	0.0005	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Schistosoma mansoni	tyrosine kinase	0.006	0.0177	0.0431
Mycobacterium ulcerans	carbonic anhydrase	0.1073	0.4112	0.3983
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0005	0.0012
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0017	0.0013	0.0218
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0126	0.0434	0.732
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0029	0.0056	0.0882
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0015	0.0005	0.0012
Echinococcus multilocularis	hypothetical protein	0.0017	0.0013	0.0057
Echinococcus multilocularis	ecdysone induced protein 78C	0.0015	0.0005	0.0021
Loa Loa (eye worm)	doublecortin family protein	0.0166	0.0591	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0015	0.0005	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0214	0.3617
Schistosoma mansoni	carbonic anhydrase	0.0029	0.0056	0.0137
Schistosoma mansoni	tyrosine kinase	0.0059	0.0173	0.0421
Brugia malayi	hypothetical protein	0.0072	0.0225	0.3753
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0126	0.0434	0.7342
Echinococcus granulosus	tubulin alpha 1C chain	0.0017	0.0013	0.0057
Brugia malayi	Protein kinase domain containing protein	0.0131	0.0455	0.7685
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.0005	0.0012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0139	0.0611
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0214	0.3617
Echinococcus granulosus	tubulin alpha chain	0.0017	0.0013	0.0057
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0005	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0056	0.0956
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.055	0.2079	0.031
Echinococcus multilocularis	tubulin alpha chain	0.0017	0.0013	0.0057
Schistosoma mansoni	alpha tubulin	0.0017	0.0013	0.0031
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0131	0.0455	0.2
Brugia malayi	TAR-binding protein	0.0069	0.0214	0.3565
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0139	0.0338
Echinococcus granulosus	tubulin alpha 3 chain	0.0017	0.0013	0.0057
Loa Loa (eye worm)	tubulin alpha chain	0.0017	0.0013	0.0218
Echinococcus multilocularis	carbonic anhydrase	0.0029	0.0056	0.0248
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.06	0.2274	1
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.0177	0.0778
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0005	0.0012
Entamoeba histolytica	hypothetical protein	0.0039	0.0098	0.0207
Echinococcus multilocularis		0.0017	0.0012	0.0051
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0017	0.0013	0.0057
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0098	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0591	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0139	0.2291
Echinococcus granulosus	carbonic anhydrase	0.0029	0.0056	0.0248
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0126	0.0434	0.1055
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0214	0.052
Echinococcus multilocularis	FTZ F1 alpha	0.0015	0.0005	0.0021
Brugia malayi	alpha-tubulin	0.0017	0.0013	0.0139
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0069	0.0213	0.4766
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0029	0.0056	0.0882
Brugia malayi	hypothetical protein	0.0166	0.0591	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0139	0.0611
Schistosoma mansoni	carbonic anhydrase-related	0.0029	0.0056	0.0137
Loa Loa (eye worm)	alpha-tubulin	0.0017	0.0013	0.0218
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0005	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Echinococcus granulosus	alpha tubulin	0.0017	0.0013	0.0057
Onchocerca volvulus		0.0072	0.0225	0.1353
Brugia malayi	tubulin alpha-2 chain	0.0017	0.0013	0.0139
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0015	0.0005	0.0012
Echinococcus granulosus	Tubulin alpha 1 chain	0.0017	0.0013	0.0057
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0029	0.0056	0.0882
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0126	0.0434	0.732
Onchocerca volvulus		0.0166	0.0591	0.3606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0139	0.0611
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0015	0.0005	0.0021
Onchocerca volvulus		0.0434	0.1629	1
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.0177	0.0778
Schistosoma mansoni	polycystin 1-related	0.0166	0.0591	0.1436
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0098	0.0429
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.006	0.0177	0.0778
Echinococcus multilocularis	peroxisome assembly protein 26	0.0017	0.0013	0.0057
Echinococcus granulosus	tubulin alpha chain	0.0017	0.0013	0.0057
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0214	0.3617
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0214	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0081
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0214	0.3565
Schistosoma mansoni	lipoxygenase	0.06	0.2274	0.5532
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0126	0.0434	0.1055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 812833