Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Vam6:Vps39 protein | 0.0104 | 0.1782 | 0.1808 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0105 | 0.1811 | 0.1838 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.2746 | 0.2786 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0104 | 0.1782 | 0.1808 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0105 | 0.1811 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0352 | 0.7577 | 0.7577 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0145 | 0.2746 | 0.2786 |
Schistosoma mansoni | protein kinase | 0.0249 | 0.5173 | 0.5249 |
Schistosoma mansoni | nephrin | 0.0035 | 0.0166 | 0.0169 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0145 | 0.2746 | 0.2786 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0379 | 0.0379 |
Echinococcus granulosus | roundabout 2 | 0.0044 | 0.0379 | 0.0385 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0105 | 0.1811 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0249 | 0.5173 | 0.5173 |
Schistosoma mansoni | tyrosine kinase | 0.045 | 0.9856 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0037 | 0.0213 | 0.0216 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0104 | 0.1782 | 0.1782 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0105 | 0.1811 | 0.1838 |
Schistosoma mansoni | tyrosine kinase | 0.0238 | 0.4903 | 0.4974 |
Brugia malayi | Protein kinase domain containing protein | 0.0105 | 0.1811 | 0.1811 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0243 | 0.5021 | 0.5095 |
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 0.2746 | 0.2746 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1782 | 0.1782 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0105 | 0.1811 | 0.1838 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0456 | 1 | 1 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0104 | 0.1782 | 0.1808 |
Echinococcus granulosus | twitchin | 0.0036 | 0.0196 | 0.0199 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0352 | 0.7577 | 0.7688 |
Schistosoma mansoni | tyrosine kinase | 0.0238 | 0.4903 | 0.4974 |
Schistosoma mansoni | tyrosine kinase | 0.0243 | 0.5021 | 0.5095 |
Schistosoma mansoni | vam6/vps39 related | 0.0104 | 0.1782 | 0.1808 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0037 | 0.0213 | 0.0216 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0243 | 0.5021 | 0.5095 |
Echinococcus multilocularis | insulin receptor | 0.0145 | 0.2746 | 0.2786 |
Schistosoma mansoni | protein kinase | 0.0353 | 0.7606 | 0.7718 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0104 | 0.1782 | 0.1808 |
Schistosoma mansoni | tyrosine kinase | 0.0243 | 0.5021 | 0.5095 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0105 | 0.1811 | 0.1838 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0104 | 0.1782 | 0.5 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0104 | 0.1782 | 0.1808 |
Echinococcus granulosus | neuroglian | 0.0035 | 0.0166 | 0.0169 |
Echinococcus multilocularis | 0.0138 | 0.2582 | 0.262 | |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0104 | 0.1782 | 0.1808 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1782 | 0.1782 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0243 | 0.5021 | 0.5095 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0426 | 0.9302 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.2746 | 0.2786 |
Echinococcus granulosus | protein kinase | 0.0249 | 0.5173 | 0.5249 |
Echinococcus granulosus | insulin receptor | 0.0145 | 0.2746 | 0.2786 |
Echinococcus multilocularis | 0.0249 | 0.5173 | 0.5249 | |
Brugia malayi | probable protein kinase | 0.0353 | 0.7606 | 0.7606 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0104 | 0.1782 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.045 | 0.9856 | 1 |
Onchocerca volvulus | 0.0414 | 0.9017 | 0.9621 | |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.1782 | 0.1808 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.045 | 0.9856 | 0.9856 |
Echinococcus multilocularis | roundabout 2 | 0.0044 | 0.0379 | 0.0385 |
Schistosoma mansoni | tyrosine kinase | 0.0238 | 0.4903 | 0.4974 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0105 | 0.1811 | 0.1811 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.045 | 0.9856 | 1 |
Schistosoma mansoni | protein kinase | 0.0105 | 0.1811 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1782 | 0.1782 |
Echinococcus multilocularis | neuroglian | 0.0035 | 0.0166 | 0.0169 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0145 | 0.2746 | 0.2746 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0105 | 0.1811 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0379 | 0.0379 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0105 | 0.1811 | 0.1838 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.045 | 0.9856 | 0.9856 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0104 | 0.1782 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.