Detailed information for compound 813999

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.534 | Formula: C24H30N6O2
  • H donors: 1 H acceptors: 4 LogP: 1.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C)c(cc1C)CN1CCc2n(CC1)c(nn2)C(NC(=O)c1cccnc1)C
  • InChi: 1S/C24H30N6O2/c1-16-13-21(32-4)17(2)12-20(16)15-29-9-7-22-27-28-23(30(22)11-10-29)18(3)26-24(31)19-6-5-8-25-14-19/h5-6,8,12-14,18H,7,9-11,15H2,1-4H3,(H,26,31)
  • InChiKey: VALNHQBVPQLUJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus c src tyrosine kinase 0.0018 0.0124 0.0085
Onchocerca volvulus 0.0093 0.2522 1
Schistosoma mansoni tyrosine kinase 0.0178 0.5212 0.5212
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1415 0.137
Loa Loa (eye worm) TK protein kinase 0.0033 0.061 0.0561
Schistosoma mansoni tyrosine kinase 0.0329 1 1
Echinococcus granulosus GPCR family 2 0.0016 0.0055 0.0016
Echinococcus multilocularis epidermal growth factor receptor 0.0178 0.5212 0.5193
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0375 0.0366
Schistosoma mansoni nephrin 0.0015 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0037 0.0747 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0819 0.0783
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.061 0.0573
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.1415 0.1381
Echinococcus granulosus heat shock protein 90 0.0026 0.0375 0.0337
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.004 0.0819 0.0783
Entamoeba histolytica protein kinase, putative 0.0033 0.061 0.0056
Schistosoma mansoni jumonji domain containing protein 0.0058 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0081
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.1065 0.1018
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0092 0.0039
Schistosoma mansoni heat shock protein 0.0032 0.0584 0.0584
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.0124 0.0085
Echinococcus multilocularis tyrosine protein kinase Blk 0.004 0.0819 0.0783
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0837 0.0789
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.0124 0.0085
Loa Loa (eye worm) TK protein kinase 0.004 0.0819 0.0771
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.1065 0.1065
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0837 0.7751
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0093 0.2522 0.2522
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1132 0.1085
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0584 0.1008
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.1023 0.0988
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.1415 0.1381
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.1023 0.0988
Loa Loa (eye worm) RNA binding protein 0.0064 0.1598 0.1554
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0055 0.0016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1023 0.0988
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0634 0.0584
Echinococcus granulosus tyrosine kinase 0.004 0.0819 0.0783
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0837 0.7751
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0375 0.0366
Echinococcus granulosus epidermal growth factor receptor 0.0178 0.5212 0.5193
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0375 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1598 0.1598
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0584 0.5246
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0584 0.0534
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1031 0.0984
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0584 0.1008
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0375 0.5
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0181 0.5322 0.5322
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1598 0.1565
Mycobacterium ulcerans integral membrane protein 0.0037 0.0747 1
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0124 0.0085
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0181 0.5322 1
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.0747 0.0343
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0584 0.1008
Echinococcus multilocularis CAAX prenyl protease 2 0.0181 0.5322 0.5304
Loa Loa (eye worm) endoplasmin 0.0032 0.0584 0.0534
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1031 0.1031
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0034 0.0634 0.0634
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0181 0.5322 1
Brugia malayi protein-tyrosine kinase 0.004 0.0819 0.0771
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0052 0.0052
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0837 0.0789
Brugia malayi Protein kinase domain containing protein 0.0107 0.2959 0.2922
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.1023 0.0988
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.0747 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1031 0.1031
Echinococcus multilocularis tyrosine protein kinase Srms 0.004 0.0819 0.0783
Giardia lamblia Hypothetical protein 0.0181 0.5322 1
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Echinococcus multilocularis tyrosine protein kinase Abl 0.0094 0.2556 0.2526
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0584 0.5246
Brugia malayi SRC-1 0.0046 0.1023 0.0976
Loa Loa (eye worm) TK/INSR protein kinase 0.0107 0.2959 0.2922
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1023 0.0988
Entamoeba histolytica CAAX prenyl protease family 0.0181 0.5322 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.1023 0.0988
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0178 0.5212 0.5193
Echinococcus granulosus CAAX prenyl protease 2 0.0181 0.5322 0.5304
Plasmodium falciparum heat shock protein 90 0.0032 0.0584 0.5246
Brugia malayi heat shock protein 90 0.0032 0.0584 0.0534
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0055 0.0003
Brugia malayi RNA binding protein 0.0064 0.1598 0.1554
Schistosoma mansoni endoplasmin 0.0032 0.0584 0.0584
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.1023 0.0988
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0055 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1598 0.1598
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0052 0.0013
Plasmodium vivax endoplasmin, putative 0.0032 0.0584 0.5246
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0584 0.0773
Treponema pallidum hypothetical protein 0.0037 0.0747 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.1065 1
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0055
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1023 0.0988
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0375 0.0612
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1598 0.1598
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1132 0.1085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0055 0.0003
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0584 0.5246
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1031 0.0984
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1598 0.1554
Schistosoma mansoni tyrosine kinase 0.0173 0.5058 0.5058
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Echinococcus multilocularis heat shock protein 90 0.0032 0.0584 0.0547
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1023 0.0988
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.1023 0.0988
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0124 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1031 0.0996
Toxoplasma gondii hypothetical protein 0.0037 0.0747 0.6853
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0665 0.0628
Echinococcus multilocularis endoplasmin 0.0026 0.0375 0.0337
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.1065 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0375 0.0612
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0584 0.0423
Loa Loa (eye worm) hypothetical protein 0.0081 0.2143 0.2102
Brugia malayi Endoplasmin precursor 0.0032 0.0584 0.0534
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1132 0.1085
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Plasmodium vivax protease, putative 0.0037 0.0747 0.6853
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1415 0.1415
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Loa Loa (eye worm) hypothetical protein 0.0093 0.2522 0.2482
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0181 0.5322 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0634 0.0584
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0375 0.0366
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1598 0.1554
Mycobacterium tuberculosis Probable integral membrane protein 0.0037 0.0747 1
Trypanosoma brucei CAAX amino terminal protease, putative 0.0181 0.5322 1
Echinococcus multilocularis heat shock protein 90 0.0026 0.0375 0.0337
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0093 0.2522 0.2522
Echinococcus multilocularis 0.0101 0.276 0.2731
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1415 0.1381
Schistosoma mansoni tyrosine kinase 0.0018 0.0124 0.0124
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0212 0.6281 0.6266
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0747 1
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0055
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0837 0.0801
Echinococcus granulosus tar DNA binding protein 0.0064 0.1598 0.1565
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1415 0.1415
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1598 0.1598
Plasmodium falciparum endoplasmin, putative 0.002 0.0187 0.1327
Echinococcus granulosus phd:f box containing protein 0.0016 0.0052 0.0013
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.1023 0.0988
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0055 0.0016
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0107 0.2959 0.2931
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0163 0.021
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0584 0.1008
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.3485 0.3451
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0584 0.1008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1023 0.0988
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.1023 0.0988
Brugia malayi Trypsin family protein 0.0093 0.2522 0.2482
Schistosoma mansoni tyrosine kinase 0.0107 0.2959 0.2959
Loa Loa (eye worm) TK/ABL protein kinase 0.0212 0.6281 0.6261
Schistosoma mansoni tyrosine kinase 0.0018 0.0124 0.0124
Schistosoma mansoni tyrosine kinase 0.0107 0.2959 0.2959
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Loa Loa (eye worm) hypothetical protein 0.0093 0.2522 0.2482
Loa Loa (eye worm) TK/EGFR protein kinase 0.0329 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0107 0.2959 0.2931
Schistosoma mansoni tyrosine kinase 0.0178 0.5212 0.5212
Echinococcus granulosus epidermal growth factor receptor 0.0329 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0055
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.1415 0.1381
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0052 0.0013
Schistosoma mansoni tyrosine kinase 0.0205 0.6072 0.6072
Echinococcus multilocularis epidermal growth factor receptor 0.0329 1 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0052 0.0013
Loa Loa (eye worm) hypothetical protein 0.0181 0.5322 0.5298
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0052 0.0013
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1023 0.0988
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.0747 0.0343
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0584 0.1008
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0181 0.5322 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0584 0.1008
Schistosoma mansoni heat shock protein 0.0032 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0016 0.0055 0.0003
Echinococcus multilocularis roundabout 2 0.0018 0.0133 0.0094
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0052 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0055 0.0016
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0375 0.0337
Schistosoma mansoni hypothetical protein 0.004 0.0837 0.0837
Echinococcus multilocularis heat shock protein 0.0032 0.0584 0.0547
Loa Loa (eye worm) hypothetical protein 0.004 0.0837 0.0789
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.061 0.0573
Schistosoma mansoni tyrosine kinase 0.0046 0.1023 0.1023
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.1065 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0052 0.0052
Schistosoma mansoni tyrosine kinase 0.0173 0.5058 0.5058
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0052 0.0013
Echinococcus multilocularis GPCR, family 2 0.0016 0.0055 0.0016
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Echinococcus granulosus heat shock protein 90 0.0032 0.0584 0.0547
Echinococcus granulosus tyrosine protein kinase Blk 0.004 0.0819 0.0783
Loa Loa (eye worm) SRC-1 0.0046 0.1023 0.0976
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.0747 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0665 0.0628
Echinococcus granulosus expressed protein 0.0047 0.1065 0.103
Schistosoma mansoni tyrosine kinase 0.0173 0.5058 0.5058
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1598 0.1554
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0375 0.0612
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.1023 0.0988
Echinococcus multilocularis expressed protein 0.0047 0.1065 0.103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0133 0.0081
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.1023 0.0988
Echinococcus granulosus heat shock protein 0.0032 0.0584 0.0547
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0837 0.7751
Schistosoma mansoni tyrosine kinase 0.0046 0.1023 0.1023
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0052 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1031 0.0996
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.1065 1
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Toxoplasma gondii CAAX amino terminal protease family protein 0.0037 0.0747 0.6853
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0052 0.0052
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0052 0.0013
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Loa Loa (eye worm) hypothetical protein 0.005 0.1132 0.1085
Brugia malayi hypothetical protein 0.0036 0.0713 0.0664
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1031 0.1031
Echinococcus multilocularis insulin receptor 0.0107 0.2959 0.2931
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0837 0.0789
Brugia malayi jmjC domain containing protein 0.0058 0.1415 0.137
Toxoplasma gondii hypothetical protein 0.0037 0.0747 0.6853
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0055
Plasmodium falciparum protease, putative 0.0037 0.0747 0.6853
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0181 0.5322 0.5322
Chlamydia trachomatis hypothetical protein 0.0037 0.0747 0.5
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0584 0.1008
Schistosoma mansoni endoplasmin 0.0032 0.0584 0.0584
Echinococcus granulosus tyrosine protein kinase ABL1 0.0212 0.6281 0.6266
Brugia malayi CAAX amino terminal protease family protein 0.0181 0.5322 0.5298
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0584 0.1008
Brugia malayi TAR-binding protein 0.0064 0.1598 0.1554
Leishmania major heat shock protein 83-1 0.0032 0.0584 0.1008
Echinococcus granulosus endoplasmin 0.0026 0.0375 0.0337
Echinococcus granulosus roundabout 2 0.0018 0.0133 0.0094
Mycobacterium ulcerans hypothetical protein 0.0037 0.0747 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0055 0.0016
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.1023 0.0988
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0052 0.0013
Echinococcus granulosus insulin receptor 0.0107 0.2959 0.2931
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0092 0.0039
Brugia malayi jmjC domain containing protein 0.0058 0.1415 0.137
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1598 0.1598
Brugia malayi Tyrosine-protein kinase abl-1 0.0094 0.2556 0.2517
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0052 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1031 0.0996
Brugia malayi hypothetical protein 0.0036 0.0713 0.0664
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.1065 0.1018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1031 0.0996

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.