Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nephrin | 0.0012 | 0.0166 | 0.0169 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0026 | 0.1207 | 0.1225 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0089 | 0.5633 | 0.5716 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.0213 | 0.0216 |
Echinococcus multilocularis | 0.0063 | 0.3797 | 0.3853 | |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.4903 | 0.4974 |
Schistosoma mansoni | vam6/vps39 related | 0.0026 | 0.1207 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1207 | 0.1207 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0027 | 0.123 | 0.1248 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0151 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0012 | 0.0189 | 0.0192 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0026 | 0.1207 | 0.1207 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0027 | 0.123 | 0.1248 |
Echinococcus multilocularis | insulin receptor | 0.0048 | 0.2746 | 0.2786 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0063 | 0.3797 | 0.3797 |
Schistosoma mansoni | protein kinase | 0.0063 | 0.3797 | 0.3853 |
Brugia malayi | Protein kinase domain containing protein | 0.0027 | 0.123 | 0.123 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0149 | 0.9856 | 1 |
Echinococcus multilocularis | neuroglian | 0.0012 | 0.0166 | 0.0169 |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.5021 | 0.5095 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0379 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0379 | 0.0379 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0027 | 0.123 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1207 | 0.1207 |
Schistosoma mansoni | tyrosine kinase | 0.0048 | 0.2746 | 0.2786 |
Echinococcus granulosus | neuroglian | 0.0012 | 0.0166 | 0.0169 |
Brugia malayi | Protein kinase domain containing protein | 0.0048 | 0.2746 | 0.2746 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0081 | 0.5021 | 0.5095 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.5633 | 0.5633 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0026 | 0.1207 | 0.1225 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0027 | 0.123 | 0.1248 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0048 | 0.2746 | 0.2786 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0027 | 0.123 | 0.1248 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0026 | 0.1207 | 0.1225 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0027 | 0.123 | 0.123 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0026 | 0.1207 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0149 | 0.9856 | 0.9856 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0027 | 0.123 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0379 | 0.0379 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1207 | 0.1207 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0048 | 0.2746 | 0.2746 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0027 | 0.123 | 0.1248 |
Echinococcus granulosus | protein kinase | 0.0063 | 0.3797 | 0.3853 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0149 | 0.9856 | 1 |
Schistosoma mansoni | protein kinase | 0.0027 | 0.123 | 0.1248 |
Schistosoma mansoni | tyrosine kinase | 0.0149 | 0.9856 | 1 |
Onchocerca volvulus | 0.0137 | 0.9017 | 0.9648 | |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.1207 | 0.1225 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0379 | 0.0385 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0149 | 0.9856 | 0.9856 |
Brugia malayi | probable protein kinase | 0.009 | 0.5656 | 0.5656 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0081 | 0.5021 | 0.5095 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0026 | 0.1207 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0081 | 0.5021 | 0.5095 |
Echinococcus granulosus | insulin receptor | 0.0048 | 0.2746 | 0.2786 |
Brugia malayi | hypothetical protein | 0.0026 | 0.1207 | 0.1207 |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.5021 | 0.5095 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0141 | 0.9302 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0048 | 0.2746 | 0.2786 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0026 | 0.1207 | 0.1225 |
Echinococcus multilocularis | 0.0046 | 0.2582 | 0.262 | |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0026 | 0.1207 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0213 | 0.0216 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0026 | 0.1207 | 0.1225 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.4903 | 0.4974 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0027 | 0.123 | 0.1248 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0026 | 0.1207 | 0.1225 |
Schistosoma mansoni | protein kinase | 0.009 | 0.5656 | 0.5739 |
Schistosoma mansoni | tyrosine kinase | 0.0048 | 0.2746 | 0.2786 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.4903 | 0.4974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.