Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0803 | 0.156 |
Loa Loa (eye worm) | integrin beta-2 | 0.0322 | 0.3815 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0174 | 0.1572 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0735 | 0.1368 |
Schistosoma mansoni | integrin alpha | 0.0157 | 0.1316 | 0.728 |
Plasmodium vivax | subtilisin-like protease 1 | 0.0729 | 1 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0174 | 0.1572 | 0.5 |
Echinococcus multilocularis | integrin alpha 3 | 0.012 | 0.0759 | 0.2977 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0174 | 0.1572 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0157 | 0.1316 | 0.1886 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0174 | 0.1572 | 0.3714 |
Schistosoma mansoni | N-myristoyltransferase | 0.0174 | 0.1572 | 0.8698 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0242 | 0.2607 | 0.6614 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0174 | 0.1572 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.0238 | 0.2549 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.012 | 0.0759 | 0.2977 |
Trypanosoma brucei | N-myristoyltransferase | 0.0174 | 0.1572 | 0.5 |
Giardia lamblia | CDC72 | 0.0174 | 0.1572 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0174 | 0.1572 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.0174 | 0.1572 | 0.2717 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0174 | 0.1572 | 0.6166 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0174 | 0.1572 | 0.5 |
Toxoplasma gondii | subtilisin SUB1 | 0.0729 | 1 | 0.5 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0174 | 0.1572 | 0.6166 |
Schistosoma mansoni | integrin beta subunit | 0.0189 | 0.1807 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0238 | 0.2549 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0322 | 0.3815 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.